Composition #1: Ismail, I.S., Ismail, N., Lajis, N. Ichthyotoxic properties and essential oils of syzygium malaccense (Myrtaceae). Pertanika Journal of Science and Technology, 2010, vol. 18, no. 1, p. 1–6. .
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Essential oil (as part-nature) (A166Q)
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Additional extraction description:
hydrodistillation
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Substance:
methyl salicylate (RF-00003930-PAR)
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Analytical method code:
GC-MS (F046A)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
8.27
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Internal remarks:
Methyl salicylate
Endpoint study
#1: Adebayo, A.H., Ogundare, O.C., Adegbite, O.S. Sub-acute evaluation of extract of syzygium malaccense in albino rats. research journal of medicinal plant, 2015, vol. 9, no. 2, p. 60–71. DOI: 10.3923/rjmp.2015.60.71.
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DOI link]
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Study relevance:
Human health
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Plant part:
Leaves (as part-nature) (A0EKT)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
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Additional plant/substance description:
ethanol
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Type of toxicological test:
short-term toxicity (CHD017TT)
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Tested organism:
Rat (as animal) (A0CNV)
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Strain of test organism:
Wistar (CHD013ST)
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Unit of exposure duration:
Day (G134A)
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Number of organisms dosed:
5
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Endpoint measured:
Concentration level (CHD013EP)
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Concentration unit:
Milligrams per kilogram body weight (G225A)
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Effect concentration:
100
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Critical effect:
HEPATOTOXICITY (TOX02A)
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Target tissue:
digestive: Liver (TT023A)
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Effect description:
inflammation of the liver cells
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Effect or parameter linked to the endpoint:
histopathology non neoplastic (CHD025BE)
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Internal remarks:
hepatotoxicity
