EFSA Compendium of Botanicals

Draft - work in progress

Stryphnodendron adstringens (Mart.) Coville

Family:: Fabaceae
Approval state:: Approved
Number of articles retrieved:: 210
Number of processed references:: 7

Compositions

#1: Tannins #2: tannins #3: tannins #4: 5-deoxyproanthocyanidins #5: robinetinidol-epigallocatechin 3-O-gallate

Endpoint Studies

#1: alpha-amylase inhibition #2: alpha-glucosidase inhibition

Genotoxicity

#1: ethanolic extract of bark genotoxic but not mutagenic

Composition #1: Porto, Jorge Marcelo Padovani., Paiva, Renato., Campos, Nadia Alves., dos Reis, Michele Valquiria., de Souza, Ana Cristina., Santos, Paulo Augusto Almeida., Braga, Francyane Tavares. Cryopreservation of seeds of barbatimao with different water contents. Australian Journal of Basic and Applied Sciences, 2014, p. 250–256. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Substance:

Tannins (RF-00004337-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tannins

Composition #2: Lopes, G.C., Sanches, A.C.C., De Toledo, C.E.M., Isler, A.C., De Mello, J.C.P. Quantitative determination of tannins in three species of Stryphnodendron by high-performance liquid chromatography Determinação quantitativa de taninos em três espécies de Stryphnodendron por cromatografia líquida de alta eficiência . brazilian journal of pharmaceutical sciences, 2009, vol. 45, no. 1, p. 135–143. DOI: 10.1590/S1984-82502009000100017. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

acetone:water (7:3)
Substance:

Tannins (RF-00004337-PAR)
Additional substance description:

total tannins
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

19
Internal remarks:

tannins

Composition #3: Ardisson, L., Godoy, J. S., Ferreira, L. A. M., Stehmann, J. R., Brandão, M. G. L. Preparação e caracterização de extratos glicólicos enriquecidos em taninos a partir das cascas de Stryphnodendron adstringens (Mart.) Coville (Barbatimão) . revista brasileira de farmacognosia, 2002, vol. 12, no. 1, p. 27–34. DOI: 10.1590/S0102-695X2002000100004. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

propylene glycol + water
Substance:

Tannins (RF-00004337-PAR)
Additional substance description:

in stem bark
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

spectrophotometry
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

10.4-30.8
Internal remarks:

tannins

Composition #4: Lopes, Gisely Cristiny., Vieira Machado, Fatima Aparecida., Mendes de Toledo, Cleyton Eduardo., Sakuragui, Cassia Monica., Palazzo de Mello, Joao Carlos. Chemotaxonomic significance of 5-deoxyproanthocyanidins in Stryphnodendron species. BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2008, vol. 36, no. 12, p. 925–931. DOI: 10.1016/j.bse.2008.10.004. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Me2CO-H2O
Substance:

Proanthocyanidins (condensed tannins) Proanthocyanidins (condensed tannins) (RF-00004370-PAR)
Additional substance description:

5-deoxyproanthocyanidins
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

5-deoxyproanthocyanidins

Composition #5: deMello, JP., Petereit, F., Nahrstedt, A. Prorobinetinidins from Stryphnodendron adstringens. PHYTOCHEMISTRY, 1996, vol. 42, no. 3, p. 857–862. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Me2CO-H20
Substance:

Proanthocyanidins (condensed tannins) Proanthocyanidins (condensed tannins) (RF-00004370-PAR)
Additional substance description:

robinetinidol-epigallocatechin 3-O-gallate
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

robinetinidol-epigallocatechin 3-O-gallate

Endpoint study #1: Souza, Paula Monteiro de., Sales, Paloma Michelle de., Simeoni, Luiz Alberto., Silva, Elton Clementino., Silveira, Damaris., Magalhaes, Perola de Oliveira. Inhibitory activity of alpha-amylase and alpha-glucosidase by plant extracts from the Brazilian cerrado. . planta medica, 2012, vol. 78, no. 4, p. 393–9. DOI: 10.1055/s-0031-1280404. [DOI link]

Study relevance:

Human health
Plant part:

Bark (as part-nature) (A066X)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

hexane + ethanol extract of stem bark
Type of toxicological test:

in vitro (CHD061TT)
Endpoint measured:

Half maximal inhibitory concentration (CHD021EP)
Concentration unit:

Microgram/millilitre (G052A)
Effect concentration:

1.86
Critical effect:

Digestive (TOX18A)
Target tissue:

digestive: Pancreas (TT024A)
Effect description:

alpha-amylase inhibition
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

alpha-amylase inhibition

Endpoint study #2: Souza, Paula Monteiro de., Sales, Paloma Michelle de., Simeoni, Luiz Alberto., Silva, Elton Clementino., Silveira, Damaris., Magalhaes, Perola de Oliveira. Inhibitory activity of alpha-amylase and alpha-glucosidase by plant extracts from the Brazilian cerrado. . planta medica, 2012, vol. 78, no. 4, p. 393–9. DOI: 10.1055/s-0031-1280404. [DOI link]

Study relevance:

Human health
Plant part:

Bark (as part-nature) (A066X)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

hexane + ethanol extract of stem bark
Type of toxicological test:

in vitro (CHD061TT)
Endpoint measured:

Half maximal inhibitory concentration (CHD021EP)
Concentration unit:

Microgram/millilitre (G052A)
Effect concentration:

0.61
Critical effect:

Digestive (TOX18A)
Target tissue:

digestive: Pancreas (TT024A)
Effect description:

alpha-glucosidase inhibition
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

alpha-glucosidase inhibition

Genotox #1: Vilar, Juliana Brandstetter., Prudente D'Oliveira, Maria Inez., Santos, Suzana da Costa., Chen, Lee Chen. Cytotoxic and genotixic investigation on barbatimao [Stryphnodendron adstringens (Mart.) Coville, 1910] extract. Brazilian Journal of Pharmaceutical Sciences, 2010, p. 687–694. .

Study category:

Genotoxicity
Type of toxicological test:

SOS/umu test (CHD035TT)
Method type:

in vitro
Tested organism:

Escherichia coli (as organism) (A0CQA)
Exogenous metabolic activation applied:

with and without
Control groups used:

yes
Endpoint measured:

DNA damage and/or repair
Is genotoxic:

Positive
Remarks on genotox study:

ethanolic extract of bark genotoxic but not mutagenic; the metabolization of the extract of this plant reduced its genotoxic activity
Internal remarks:

ethanolic extract of bark genotoxic but not mutagenic
Internal ID:

CAPLUS_2011:914608