EFSA Compendium of Botanicals

Draft - work in progress

Strychnos wallichiana Steud. ex A. DC. // Strychnos gauthierana Pierre ex Dop

Family:: Loganiaceae
Approval state:: Approved
Number of articles retrieved:: 16
Number of processed references:: 2

Compositions

#1: Novacine and derivatives #2: Strychnine and derivatives #3: N-methyl-sec-pseudo-beta-colubrine #4: Icajine and derivatives #5: Brucine and derivatives #6: vomicine #7: alpha-colubrine #8: Strychnine and derivatives #9: brucine

Endpoint Studies

Genotoxicity

Composition #1: Bisset, N. G., Choudhury, A. K. Alkaloids from the leaves of Strychnos wallichiana. Phytochemistry (Elsevier), 1974, p. 259–263. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CHCl3
Substance:

novacine (RF-00011211-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.133
Internal remarks:

Novacine and derivatives

Composition #2: Bisset, N. G., Choudhury, A. K. Alkaloids from the leaves of Strychnos wallichiana. Phytochemistry (Elsevier), 1974, p. 259–263. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CHCl3
Substance:

strychnine (RF-00003591-PAR)
Additional substance description:

Strychnine and derivatives
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.044
Internal remarks:

Strychnine and derivatives

Composition #3: Bisset, N. G., Choudhury, A. K. Alkaloids from the leaves of Strychnos wallichiana. Phytochemistry (Elsevier), 1974, p. 259–263. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

Beta-colubrine (RF-00011439-PAR)
Additional substance description:

N-methyl-sec-pseudo-beta-colubrine
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.0003
Internal remarks:

N-methyl-sec-pseudo-beta-colubrine

Composition #4: Bisset, N. G., Choudhury, A. K. Alkaloids from the leaves of Strychnos wallichiana. Phytochemistry (Elsevier), 1974, p. 259–263. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CHCl3
Substance:

icajine (RF-00011216-PAR)
Additional substance description:

Icajine and derivatives
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.34
Internal remarks:

Icajine and derivatives

Composition #5: Bisset, N. G., Choudhury, A. K. Alkaloids from the leaves of Strychnos wallichiana. Phytochemistry (Elsevier), 1974, p. 259–263. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CHCl3
Substance:

Brucine (RF-00011214-PAR)
Additional substance description:

Brucine and derivatives
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.0103
Internal remarks:

Brucine and derivatives

Composition #6: Bisset, N.G., Phillipson, J.D. Alkaloids from the seeds of Strychnos wallichiana Steud. ex DC. (Strychnos cinnamomifolia Thwaites var. wightii A.W. Hill). Journal of Pharmacy and Pharmacology, 1973, vol. 25, no. 7, p. 563–569. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

vomicine (RF-00011215-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

vomicine

Composition #7: Bisset, N.G., Phillipson, J.D. Alkaloids from the seeds of Strychnos wallichiana Steud. ex DC. (Strychnos cinnamomifolia Thwaites var. wightii A.W. Hill). Journal of Pharmacy and Pharmacology, 1973, vol. 25, no. 7, p. 563–569. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

alpha-colubrine (RF-00011219-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

alpha-colubrine

Composition #8: Bisset, N.G., Phillipson, J.D. Alkaloids from the seeds of Strychnos wallichiana Steud. ex DC. (Strychnos cinnamomifolia Thwaites var. wightii A.W. Hill). Journal of Pharmacy and Pharmacology, 1973, vol. 25, no. 7, p. 563–569. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

strychnine (RF-00003591-PAR)
Additional substance description:

Strychnine and derivatives
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Strychnine and derivatives

Composition #9: Bisset, N.G., Phillipson, J.D. Alkaloids from the seeds of Strychnos wallichiana Steud. ex DC. (Strychnos cinnamomifolia Thwaites var. wightii A.W. Hill). Journal of Pharmacy and Pharmacology, 1973, vol. 25, no. 7, p. 563–569. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

Brucine (RF-00011214-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

brucine