EFSA Compendium of Botanicals

Draft - work in progress

Strychnos potatorum L.f.

Family:: Loganiaceae
Approval state:: Approved
Number of articles retrieved:: 195
Number of processed references:: 5

Compositions

#1: #2: indole alkaloids #3: Alkaloids #4: saponins #5: anthraquinones #6: tannins #7: harmane alkaloids

Endpoint Studies

Genotoxicity

Composition #1: Singh, Harkisham., Kapoor, K. V. Investigation of Strychnos spp. IV. Pharmacological studies of alkaloids of Strychnos potatorum. planta medica, 1976, p. 226–233. .

Language:

English (en)
Substance:

Alkaloids (RF-00004360-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)

Composition #2: Massiot, Georges., Thepenier, Philippe., Jacquier, Marie Jose., Le Men-Olivier, Louisette., Delaude, Clement. Normavacurine and minfiensine, two new alkaloids with C19H22N2O formula from Strychnos species. heterocycles, 1989, p. 1435–1438. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

indole alkaloids (RF-00004503-PAR)
Additional substance description:

normavacurine and minfiensine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

indole alkaloids

Composition #3: Sivagnanam, Selva Kumar., Rao, Ram Krishna., Mudiganti., Dar, Umar Mushtaq., Jeelani, Peerzada Gh. Preliminary phytochemical analysis of Artemesia amygdalina, Nerium odorum and Strychnos potatorum. Journal of Pharmacy Research, 2012, p. 3734–3739. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol, methanol, chloroform
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids

Composition #4: Sivagnanam, Selva Kumar., Rao, Ram Krishna., Mudiganti., Dar, Umar Mushtaq., Jeelani, Peerzada Gh. Preliminary phytochemical analysis of Artemesia amygdalina, Nerium odorum and Strychnos potatorum. Journal of Pharmacy Research, 2012, p. 3734–3739. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

saponins

Composition #5: Sivagnanam, Selva Kumar., Rao, Ram Krishna., Mudiganti., Dar, Umar Mushtaq., Jeelani, Peerzada Gh. Preliminary phytochemical analysis of Artemesia amygdalina, Nerium odorum and Strychnos potatorum. Journal of Pharmacy Research, 2012, p. 3734–3739. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol, chloroform, ethyl acetate
Substance:

anthraquinones (RF-00004343-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

anthraquinones

Composition #6: Sivagnanam, Selva Kumar., Rao, Ram Krishna., Mudiganti., Dar, Umar Mushtaq., Jeelani, Peerzada Gh. Preliminary phytochemical analysis of Artemesia amygdalina, Nerium odorum and Strychnos potatorum. Journal of Pharmacy Research, 2012, p. 3734–3739. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol, methanol
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

tannins

Composition #7: MASSIOT, G., THEPENIER, P., JACOUIER, MJ., LEMENOLIVIER, L., DELAUDE, C. ALKALOIDS FROM ROOTS OF STRYCHNOS-POTATORUM. phytochemistry, 1992, vol. 31, no. 8, p. 2873–2876. DOI: 10.1016/0031-9422(92)83650-N. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

harmane alkaloids (RF-00004301-PAR)
Additional substance description:

24 alkaloids identified
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

harmane alkaloids

Endpoint study #1: Gupta, R.S., Kanwar, M., Kachhawa, J.B.S. Effect of methanol seed extract of Strychnos potatorum on accessory sex organs of male albino rats. pharmacologyonline, 2007, vol. 1, p. 79–83. .

Study relevance:

Human health
Plant part:

Seed (as part-nature) (A066P)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

methanol 70%
Type of toxicological test:

subchronic (CHD013TT)
Tested organism:

Rat (as animal) (A0CNV)
Sex:

Male
Exposure duration:

60.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

5
Control groups used:

yes
Endpoint measured:

Concentration level (CHD013EP)
Concentration unit:

Milligrams per person per day (G232A)
Effect concentration:

100
Critical effect:

REPRODUCTIVE (TOX05A)
Target tissue:

urogenital: Testes (TT050A)
Effect description:

weights of epididymides, seminal vesicles, ventral prostates and vas deferens decreased; Testosterone concentration of serum depleted by 56.60%
Effect or parameter linked to the endpoint:

organ weights (CHD012BE)
Internal remarks:

contraceptive effect in male rats