Endpoint study
#1: Saka, Kasim Lateef., Kudirat, Okunowo., James, Olaitan Olatunde., Olugbenga, Fajemirokun Timothy. The effects of the leaf water extract of Struchium sparganophora (Linn.) Ktze asteraceae on the hematopoietic parameters and the organ system of rats. . pakistan journal of pharmaceutical sciences, 2013, vol. 26, no. 6, p. 1203–7. .
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Study relevance:
Human health
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Substance:
Saponins (RF-00004333-PAR)
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Plant part:
Leaves (as part-nature) (A0EKT)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
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Additional plant/substance description:
water
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Type of toxicological test:
short-term toxicity (CHD017TT)
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Tested organism:
Rat (as animal) (A0CNV)
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Strain of test organism:
Wistar (CHD013ST)
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-
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Unit of exposure duration:
Day (G134A)
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Number of organisms dosed:
5
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Endpoint measured:
Concentration level (CHD013EP)
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Concentration unit:
Grams per kilogram body weight per day (G212A)
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Effect concentration:
0.2
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Critical effect:
HEMOPOIETIC (TOX10A)
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Target tissue:
cardiovascular / haematological: Blood Coagulation (TT010A)
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Effect description:
platelets decreased significantly due to lysis of blood cells and probably suppression of blood cell synthesis by saponins found in the leaf extract
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Effect or parameter linked to the endpoint:
haematology (CHD023BE)
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Internal remarks:
platelet decrease
Endpoint study
#2: Saka, Kasim Lateef., Kudirat, Okunowo., James, Olaitan Olatunde., Olugbenga, Fajemirokun Timothy. The effects of the leaf water extract of Struchium sparganophora (Linn.) Ktze asteraceae on the hematopoietic parameters and the organ system of rats. . pakistan journal of pharmaceutical sciences, 2013, vol. 26, no. 6, p. 1203–7. .
-
Study relevance:
Human health
-
Plant part:
Leaves (as part-nature) (A0EKT)
-
Preparation/Extraction method:
Solvent extraction (A0BZR)
-
Additional plant/substance description:
water
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Type of toxicological test:
short-term toxicity (CHD017TT)
-
Tested organism:
Rat (as animal) (A0CNV)
-
Strain of test organism:
Wistar (CHD013ST)
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-
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Unit of exposure duration:
Day (G134A)
-
Number of organisms dosed:
5
-
-
Endpoint measured:
Concentration level (CHD013EP)
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Concentration unit:
Grams per kilogram body weight per day (G212A)
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Effect concentration:
0.2-1.6
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Critical effect:
HEPATOTOXICITY (TOX02A)
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Target tissue:
digestive: Liver (TT023A)
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Effect description:
hepatocytic degeneration and vacuolation
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Effect or parameter linked to the endpoint:
histopathology non neoplastic (CHD025BE)
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Internal remarks:
hepatotoxicity
