EFSA Compendium of Botanicals

Draft - work in progress

Stillingia lineata (Lam.) Müll.Arg. // Stillingia lineata subsp. lineata

Family:: Euphorbiaceae
Approval state:: Approved
Number of articles retrieved:: 7
Number of processed references:: 2

Compositions

#1: tonantzitlolone C #2: tonantzitlolone A #3: tonantzitlolone B #4: tonantzitlolone D #5: tonantzitlolone E #6: tonantzitlolone F #7: tonantzitlolone G #8: tonantzitlolone H #9: tonantzitlolone I #10: tonantzitloic acid #11: tonantzitlolone A #12: tonantzitlolone B #13: tonantzitlolone C

Endpoint Studies

Genotoxicity

Composition #1: Olivon, Florent., Palenzuela, Heliciane., Girard-Valenciennes, Emmanuelle., Neyts, Johan., Pannecouque, Christophe., Roussi, Fanny., Grondin, Isabelle., Leyssen, Pieter., Litaudon, Marc. Antiviral Activity of Flexibilane and Tigliane Diterpenoids from Stillingia lineata. JOURNAL OF NATURAL PRODUCTS, 2015, vol. 78, no. 5, p. 1119–1128. DOI: 10.1021/acs.jnatprod.5b00116. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethylacetate
Substance:

Tonantzitlolone C (RF-00011298-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, LC-HRESIMS analysis, optical rotation, UV
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

tonantzitlolone C

Composition #2: Olivon, Florent., Palenzuela, Heliciane., Girard-Valenciennes, Emmanuelle., Neyts, Johan., Pannecouque, Christophe., Roussi, Fanny., Grondin, Isabelle., Leyssen, Pieter., Litaudon, Marc. Antiviral Activity of Flexibilane and Tigliane Diterpenoids from Stillingia lineata. JOURNAL OF NATURAL PRODUCTS, 2015, vol. 78, no. 5, p. 1119–1128. DOI: 10.1021/acs.jnatprod.5b00116. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethylacetate
Substance:

Tonantzitlolone A (RF-00011293-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, LC-HRESIMS analysis, optical rotation, UV
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

tonantzitlolone A

Composition #3: Olivon, Florent., Palenzuela, Heliciane., Girard-Valenciennes, Emmanuelle., Neyts, Johan., Pannecouque, Christophe., Roussi, Fanny., Grondin, Isabelle., Leyssen, Pieter., Litaudon, Marc. Antiviral Activity of Flexibilane and Tigliane Diterpenoids from Stillingia lineata. JOURNAL OF NATURAL PRODUCTS, 2015, vol. 78, no. 5, p. 1119–1128. DOI: 10.1021/acs.jnatprod.5b00116. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethylacetate
Substance:

Tonantzitlolone B (RF-00011475-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, LC-HRESIMS analysis, optical rotation, UV
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

tonantzitlolone B

Composition #4: Olivon, Florent., Palenzuela, Heliciane., Girard-Valenciennes, Emmanuelle., Neyts, Johan., Pannecouque, Christophe., Roussi, Fanny., Grondin, Isabelle., Leyssen, Pieter., Litaudon, Marc. Antiviral Activity of Flexibilane and Tigliane Diterpenoids from Stillingia lineata. JOURNAL OF NATURAL PRODUCTS, 2015, vol. 78, no. 5, p. 1119–1128. DOI: 10.1021/acs.jnatprod.5b00116. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethylacetate
Substance:

Tonantzitlolone D (RF-00011297-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, LC-HRESIMS analysis, optical rotation, UV
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

tonantzitlolone D

Composition #5: Olivon, Florent., Palenzuela, Heliciane., Girard-Valenciennes, Emmanuelle., Neyts, Johan., Pannecouque, Christophe., Roussi, Fanny., Grondin, Isabelle., Leyssen, Pieter., Litaudon, Marc. Antiviral Activity of Flexibilane and Tigliane Diterpenoids from Stillingia lineata. JOURNAL OF NATURAL PRODUCTS, 2015, vol. 78, no. 5, p. 1119–1128. DOI: 10.1021/acs.jnatprod.5b00116. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethylacetate
Substance:

Tonantzitlolone E (RF-00011299-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, LC-HRESIMS analysis, optical rotation, UV
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

tonantzitlolone E

Composition #6: Olivon, Florent., Palenzuela, Heliciane., Girard-Valenciennes, Emmanuelle., Neyts, Johan., Pannecouque, Christophe., Roussi, Fanny., Grondin, Isabelle., Leyssen, Pieter., Litaudon, Marc. Antiviral Activity of Flexibilane and Tigliane Diterpenoids from Stillingia lineata. JOURNAL OF NATURAL PRODUCTS, 2015, vol. 78, no. 5, p. 1119–1128. DOI: 10.1021/acs.jnatprod.5b00116. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethylacetate
Substance:

Tonantzitlolone F (RF-00011296-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, LC-HRESIMS analysis, optical rotation, UV
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

tonantzitlolone F

Composition #7: Olivon, Florent., Palenzuela, Heliciane., Girard-Valenciennes, Emmanuelle., Neyts, Johan., Pannecouque, Christophe., Roussi, Fanny., Grondin, Isabelle., Leyssen, Pieter., Litaudon, Marc. Antiviral Activity of Flexibilane and Tigliane Diterpenoids from Stillingia lineata. JOURNAL OF NATURAL PRODUCTS, 2015, vol. 78, no. 5, p. 1119–1128. DOI: 10.1021/acs.jnatprod.5b00116. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethylacetate
Substance:

Tonantzitlolone G (RF-00011301-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, LC-HRESIMS analysis, optical rotation, UV
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

tonantzitlolone G

Composition #8: Olivon, Florent., Palenzuela, Heliciane., Girard-Valenciennes, Emmanuelle., Neyts, Johan., Pannecouque, Christophe., Roussi, Fanny., Grondin, Isabelle., Leyssen, Pieter., Litaudon, Marc. Antiviral Activity of Flexibilane and Tigliane Diterpenoids from Stillingia lineata. JOURNAL OF NATURAL PRODUCTS, 2015, vol. 78, no. 5, p. 1119–1128. DOI: 10.1021/acs.jnatprod.5b00116. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethylacetate
Substance:

Tonantzitlolone H (RF-00011300-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, LC-HRESIMS analysis, optical rotation, UV
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

tonantzitlolone H

Composition #9: Olivon, Florent., Palenzuela, Heliciane., Girard-Valenciennes, Emmanuelle., Neyts, Johan., Pannecouque, Christophe., Roussi, Fanny., Grondin, Isabelle., Leyssen, Pieter., Litaudon, Marc. Antiviral Activity of Flexibilane and Tigliane Diterpenoids from Stillingia lineata. JOURNAL OF NATURAL PRODUCTS, 2015, vol. 78, no. 5, p. 1119–1128. DOI: 10.1021/acs.jnatprod.5b00116. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethylacetate
Substance:

Tonantzitlolone I (RF-00011294-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, LC-HRESIMS analysis, optical rotation, UV
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

tonantzitlolone I

Composition #10: Olivon, Florent., Palenzuela, Heliciane., Girard-Valenciennes, Emmanuelle., Neyts, Johan., Pannecouque, Christophe., Roussi, Fanny., Grondin, Isabelle., Leyssen, Pieter., Litaudon, Marc. Antiviral Activity of Flexibilane and Tigliane Diterpenoids from Stillingia lineata. JOURNAL OF NATURAL PRODUCTS, 2015, vol. 78, no. 5, p. 1119–1128. DOI: 10.1021/acs.jnatprod.5b00116. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethylacetate
Substance:

Tonantzitloic acid (RF-00011295-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, LC-HRESIMS analysis, optical rotation, UV
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

tonantzitloic acid

Composition #11: Techer, S., Girard-Valenciennes, E., Retailleau, P., Neyts, J., Gueritte, F., Leyssen, P., Litaudon, M., Smadja, J., Grondin, I. Tonantzitlolones from Stillingia lineata ssp lineata as potential inhibitors of chikungunya virus. PHYTOCHEMISTRY LETTERS, 2015, vol. 12, p. 313–319. DOI: 10.1016/j.phytol.2015.04.023. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethylacetate
Substance:

Tonantzitlolone A (RF-00011293-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, HRESIMS analysis, Xrays
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

tonantzitlolone A

Composition #12: Techer, S., Girard-Valenciennes, E., Retailleau, P., Neyts, J., Gueritte, F., Leyssen, P., Litaudon, M., Smadja, J., Grondin, I. Tonantzitlolones from Stillingia lineata ssp lineata as potential inhibitors of chikungunya virus. PHYTOCHEMISTRY LETTERS, 2015, vol. 12, p. 313–319. DOI: 10.1016/j.phytol.2015.04.023. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethylacetate
Substance:

Tonantzitlolone B (RF-00011475-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

tonantzitlolone B

Composition #13: Techer, S., Girard-Valenciennes, E., Retailleau, P., Neyts, J., Gueritte, F., Leyssen, P., Litaudon, M., Smadja, J., Grondin, I. Tonantzitlolones from Stillingia lineata ssp lineata as potential inhibitors of chikungunya virus. PHYTOCHEMISTRY LETTERS, 2015, vol. 12, p. 313–319. DOI: 10.1016/j.phytol.2015.04.023. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethylacetate
Substance:

Tonantzitlolone C (RF-00011298-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, HRESIMS analysis, optical rotation, UV, IR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

tonantzitlolone C