EFSA Compendium of Botanicals

Draft - work in progress

Stephania glabra (Roxb.) Miers

Family:: Menispermaceae
Approval state:: Approved
Number of articles retrieved:: 113
Number of processed references:: 9

Compositions

#1: Tetrahydropalmatine #2: Alkaloids (total) #3: Alkaloid (remerine) #4: Isoflavone #5: Tetrahydropalmatine #6: Alkaloids #7: cycleanine #8: l -Tetrahydropalmatine #9: Alkaloids #10: cycleanine #11: Alkaloid #12: Aporphine alkaloids #13: Protoberberines

Endpoint Studies

Genotoxicity

Composition #1: Fang, K'uo-Chin., Fadeeva, I. I., Il'inskaya, T. N. Stephania alkaloids. II. Alkaloids of Stephania glabra. khimiya prirodnykh soedinenii, 1965, p. 392–394. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

dichloromethane
Substance:

tetrahydropalmatin (RF-00003602-PAR)
Additional substance description:

tetrahydropalmatine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.65
Internal remarks:

Tetrahydropalmatine

Composition #2: Fang, K'uo-Chin., Fadeeva, I. I., Il'inskaya, T. N. Stephania alkaloids. II. Alkaloids of Stephania glabra. khimiya prirodnykh soedinenii, 1965, p. 392–394. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

dichloromethane
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

Total alkaloids
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.99
Internal remarks:

Alkaloids (total)

Composition #3: Ngo, Van Thu., Nuhn, P. Alkaloids of Stephania glabra. pharmazie, 1971, p. 504–505. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

remerine
Analytical method code:

Chromatographic tests (F015A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloid (remerine)

Composition #4: Pal, Mahesh., Chaudhuri, P. K., Sharma, R. P., Gauniyal, H. M. Isoflavonoid C-glycoside from Stephania glabra.. fitoterapia, 1995 . .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Unspecified
Substance:

isoflavones (RF-00004359-PAR)
Additional substance description:

7,4'-Dihydroxyisoflavone 8-C-β-glucopyranoside
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isoflavone

Composition #5: Nguyen, Tien Vung., Pham, Thanh Ky., Bui, Kim Lien., Trinh, Van Bao. Evaluation of the mutagenic potential on chromosomes of L-tetrahydropalmatine extracted from rhizoma of Stephania glabra (Roxb.) Miers. tap chi duoc hoc, 1998, p. 19–21. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

tetrahydropalmatin (RF-00003602-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tetrahydropalmatine

Composition #6: Wa, M.T., Beal, J.L., Doskotch, R.W. A study of the quaternary alkaloids of Stephania glabra. lloydia, 1967, vol. 30, no. 3, p. 245–249. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

Berberine alkaloids (palmatine, columbamine, jatrorrhizine), Aporphine alkaloid (magnoflorine)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids

Composition #7: Shchelchkova, I.I., Il'inskaya, T.N., Kuzovkov, A.D. The alkaloids of Stephania glabra. Chemistry of Natural Compounds, 1965, vol. 1, no. 4, p. 210–212. DOI: 10.1007/BF00566871. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Xylene, sulfuric acid
Substance:

cycleanine (RF-00004243-PAR)
Analytical method code:

IR and Raman Spectroscopy (F010A)
Analytical method - additional description:

IR Spectrum
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

cycleanine

Composition #8: Shchelchkova, I.I., Il'inskaya, T.N., Kuzovkov, A.D. The alkaloids of Stephania glabra. Chemistry of Natural Compounds, 1965, vol. 1, no. 4, p. 210–212. DOI: 10.1007/BF00566871. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Xylene, sulfuric acid
Substance:

tetrahydropalmatin (RF-00003602-PAR)
Analytical method code:

IR and Raman Spectroscopy (F010A)
Analytical method - additional description:

IR Spectrum
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

l -Tetrahydropalmatine

Composition #9: Shchelchkova, I.I., Il'inskaya, T.N., Kuzovkov, A.D. The alkaloids of Stephania glabra. Chemistry of Natural Compounds, 1965, vol. 1, no. 4, p. 210–212. DOI: 10.1007/BF00566871. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Xylene, sulfuric acid
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

rotundine, hindaricine, stepharine
Analytical method code:

IR and Raman Spectroscopy (F010A)
Analytical method - additional description:

IR Spectrum
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids

Composition #10: Martinez, JA., Bello, A., Rubio, LL., Rodriguez, C., Galan, L., Caudales, E., Alvarez, JL. Calcium antagonist properties of the bisbenzylisoquinoline alkaloid cycleanine. FUNDAMENTAL & CLINICAL PHARMACOLOGY, 1998, vol. 12, no. 2, p. 182–187. .

Language:

English (en)
Plant part:

Bulb / clove (as part-nature) (A067A)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

cycleanine (RF-00004243-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

cycleanine

Composition #11: Semwal, Deepak Kumar., Rawat, Usha. Gindarudine, a novel morphine alkaloid from Stephania glabra. CHINESE CHEMICAL LETTERS, 2009, vol. 20, no. 7, p. 823–826. DOI: 10.1016/j.cclet.2009.03.002. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

Morphine alkaloid (gindarudine)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

2D NMR, COSY, HMBC, NOESY
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloid

Composition #12: CAVA, MP., NOMURA, K., TALAPATR.SK., MITCHELL, MJ., SCHLESSI.RH., BUCK, KT., BEAL, JL., DOUGLAS, B., RAFFAUF, RF., WEISBACH, JA. ALKALOIDS OF STEPHANIA GLABRA . A DIRECT CHEMICAL CORRELATION OF ABSOLUTE CONFIGURATION OF SOME BENZYLTETRAHYDROISOQUINOLINE PROAPORPHINE AND APORPHINE ALKALOIDS . A NEW PROTOBERBERINE ALKALOID . journal of organic chemistry, 1968, vol. 33, no. 7, p. 2785–&. DOI: 10.1021/jo01271a037. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Aporphine alkaloids (RF-00010806-PAR)
Additional substance description:

(+)-stepharine, (+)-pronuciferine
Analytical method code:

IR and Raman Spectroscopy (F010A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Aporphine alkaloids

Composition #13: CAVA, MP., NOMURA, K., TALAPATR.SK., MITCHELL, MJ., SCHLESSI.RH., BUCK, KT., BEAL, JL., DOUGLAS, B., RAFFAUF, RF., WEISBACH, JA. ALKALOIDS OF STEPHANIA GLABRA . A DIRECT CHEMICAL CORRELATION OF ABSOLUTE CONFIGURATION OF SOME BENZYLTETRAHYDROISOQUINOLINE PROAPORPHINE AND APORPHINE ALKALOIDS . A NEW PROTOBERBERINE ALKALOID . journal of organic chemistry, 1968, vol. 33, no. 7, p. 2785–&. DOI: 10.1021/jo01271a037. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

protoberberine (RF-00003553-PAR)
Additional substance description:

(-)-tetrahydropalmatine, (-)-corydalmine, (-)-stepholidine
Analytical method code:

IR and Raman Spectroscopy (F010A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Protoberberines