EFSA Compendium of Botanicals

Draft - work in progress

Stemona japonica (Blume) Miq.

Family:: Stemonaceae
Approval state:: Approved
Number of articles retrieved:: 209
Number of processed references:: 7

Compositions

#1: Total alkaloids #2: Alkaloids (stemodiol) #3: Alkaloids (stemofoline) #4: Alkaloids (croomine) #5: Alkaloids #6: Neolignan (Japonin A) #7: Benzoquinone (Japonin C) #8: Anthraquinone (Japonin D) #9: Alkaloids

Endpoint Studies

Genotoxicity

Composition #1: Cong, X. D., Xu, G. J., Jin, R. L., Zhi, H. J. Pharmacognostic studies on Baibu radix stemonae and allied drugs. IX. Determination and evaluation of total alkaloid content in the roots of Chinese Stemona spp. yaoxue xuebao, 1992, p. 556–560. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Unspecified
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

Total alkaloids
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.83-1.43
Internal remarks:

Total alkaloids

Composition #2: Ye, Yang., Xu, Rensheng. Studies on new alkaloids of Stemona japonica. chinese chemical letters, 1992, p. 511–514. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Unspecified
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

stemodiol
Analytical method code:

Nuclear Magnetic Resonance (NMR) and Electron Spin Resonance (ESR) spectroscopy (F060A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids (stemodiol)

Composition #3: Irie, H., Masaki, N., Ohno, K., Osaki, K., Taga, T., Uyeo, S. The crystal structure of a new alkaloid, stemofoline, from Stemona japonica. Journal of the Chemical Society D: Chemical Communications, 1970, no. 17, p. 1066–None. DOI: 10.1039/C29700001066. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

stem and leaves of plant used in the study
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

Stemofoline
Analytical method - additional description:

x-ray crystallographic
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids (stemofoline)

Composition #4: Yi Min., xia Xue., Wu Hoi-Yan., Tian Hai-Yan., Huang Chao., But Paul Pui-Hay., Shaw Pang-Chui., Jiang Ren-Wang. Structures and Chemotaxonomic Significance of Stemona Alkaloids from Stemona japonica. natural product communications, 2015, p. 2097–2099. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

croomine
Analytical method code:

Nuclear Magnetic Resonance (NMR) and Electron Spin Resonance (ESR) spectroscopy (F060A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids (croomine)

Composition #5: Zhou, Y., Jiang, RW., Hon, PM., Xu, YT., Chan, YM., Chan, TWD., Xu, HX., Ding, LS., But, PPH., Shaw, PC. Analyses of Stemona alkaloids in Stemona tuberosa by liquid chromatography/tandem mass spectrometry. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2006, vol. 20, no. 6, p. 1030–1038. DOI: 10.1002/rcm.2409. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol (95%)
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

stemotinine, maistemonine, neostemonine, protostemonine
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids

Composition #6: Yang, Xin-Zhou., Lin, Li-Gen., Tang, Chun-Ping., Liu, Yong-Qiang., Ye, Yang. Nonalkaloid constituents from Stemona japonica. HELVETICA CHIMICA ACTA, 2007, vol. 90, no. 2, p. 318–325. DOI: 10.1002/hlca.200790036. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

neolignans (RF-00004386-PAR)
Additional substance description:

japonin A
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Neolignan (Japonin A)

Composition #7: Yang, Xin-Zhou., Lin, Li-Gen., Tang, Chun-Ping., Liu, Yong-Qiang., Ye, Yang. Nonalkaloid constituents from Stemona japonica. HELVETICA CHIMICA ACTA, 2007, vol. 90, no. 2, p. 318–325. DOI: 10.1002/hlca.200790036. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

benzoquinones (RF-00010840-PAR)
Additional substance description:

japonin C
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Benzoquinone (Japonin C)

Composition #8: Yang, Xin-Zhou., Lin, Li-Gen., Tang, Chun-Ping., Liu, Yong-Qiang., Ye, Yang. Nonalkaloid constituents from Stemona japonica. HELVETICA CHIMICA ACTA, 2007, vol. 90, no. 2, p. 318–325. DOI: 10.1002/hlca.200790036. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

anthraquinones (RF-00004343-PAR)
Additional substance description:

phenanthraquinone (Japonin D)
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Anthraquinone (Japonin D)

Composition #9: YE, Y., QIN, GW., XU, RS. STUDIES ON STEMONA ALKALOIDS .6. ALKALOIDS OF STEMONA-JAPONICA. JOURNAL OF NATURAL PRODUCTS, 1994, vol. 57, no. 5, p. 665–669. DOI: 10.1021/np50107a019. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

petroleum ether-Me2CO,
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

stemonamide, isostemonamide, stemonamine, isostemonamine, maistemonine
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids