EFSA Compendium of Botanicals

Draft - work in progress

Stellera chamaejasme L.

Family:: Thymelaeaceae
Approval state:: Approved
Number of articles retrieved:: 648
Number of processed references:: 7

Compositions

#1: Daphnoretin (isodaphnoretin B) #2: isobergapten #3: sphondin #4: pinoresinol #5: Huratoxin #6: simplexin #7: Isoscopoletin #8: Isopimpinellin #9: Scopoletin #10: Coumarin (daphnetin) #11: Umbelliferone #12: Eugenol #13: daphnoretin #14: umbelliferone

Endpoint Studies

#1: Poisonous to grazing animals. Symptoms of acute toxicity include vomiting, abdominal pain, diarrhoea, whole body convulsion, palpitations, hyperthyroidism and possibly death. Abortions are also linked to poisoning.

Genotoxicity

Composition #1: Yang Guo-Hong., Chen Dao-Feng. Isodaphnoretin B, a new bicoumarin from Stellera chamaejasme. chinese journal of natural medicines, 2006, vol. 4, no. 6, p. 425–427. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Substance:

daphnoretin (RF-00004252-PAR)
Additional substance description:

Isodaphnoretin B
Analytical method code:

Nuclear Magnetic Resonance (NMR) and Electron Spin Resonance (ESR) spectroscopy (F060A)
Analytical method - additional description:

NMR, UV, IR, MS and optical rotations
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Daphnoretin (isodaphnoretin B)

Composition #2: Tikhomirova, L. I., Markova, L. P., Tumbaa, H., Kuznetsova, G. A. Coumarins from Stellera chamaejasmae. Khimiya Prirodnykh Soedinenii, 1974 . .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

isobergapten (RF-00003441-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

IR spectrum and by chromatography
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

isobergapten

Composition #3: Tikhomirova, L. I., Markova, L. P., Tumbaa, H., Kuznetsova, G. A. Coumarins from Stellera chamaejasmae. Khimiya Prirodnykh Soedinenii, 1974 . .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

sphondin (RF-00004060-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

IR spectrum and by chromatography
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

sphondin

Composition #4: Niwa, Masatake., Tatematsu, Hiroshi., Liu, G., Chen, X., Hirata, Yoshimasa. Constituents of Stellera chamaejasme L. tennen yuki kagobutsu toronkai koen yoshishu, 1985, p. 734–741. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

Pinoresinol (RF-00011088-PAR)
Additional substance description:

two other lignans isolated, lirioresinol B and matairesinol
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

pinoresinol

Composition #5: Niwa, Masatake., Tatematsu, Hiroshi., Liu, G., Chen, X., Hirata, Yoshimasa. Constituents of Stellera chamaejasme L. tennen yuki kagobutsu toronkai koen yoshishu, 1985, p. 734–741. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

huratoxin (RF-00003422-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Huratoxin

Composition #6: Niwa, Masatake., Tatematsu, Hiroshi., Liu, G., Chen, X., Hirata, Yoshimasa. Constituents of Stellera chamaejasme L. tennen yuki kagobutsu toronkai koen yoshishu, 1985, p. 734–741. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

simplexin (RF-00003577-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

simplexin

Composition #7: Yang, Cai-xia., Wei, Bin., Wang, Fang-ping., Su, Xiao-long. Study on chemical components from the roots of Stellera chamaejasme L.. tianran chanwu yanjiu yu kaifa, 2012, p. 1374–1376. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol (95%)
Substance:

Isoscopoletin (RF-00010985-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isoscopoletin

Composition #8: Yang, Cai-xia., Wei, Bin., Wang, Fang-ping., Su, Xiao-long. Study on chemical components from the roots of Stellera chamaejasme L.. tianran chanwu yanjiu yu kaifa, 2012, p. 1374–1376. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol (95%)
Substance:

Isopimpinellin (RF-00003784-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isopimpinellin

Composition #9: Yang, Cai-xia., Wei, Bin., Wang, Fang-ping., Su, Xiao-long. Study on chemical components from the roots of Stellera chamaejasme L.. tianran chanwu yanjiu yu kaifa, 2012, p. 1374–1376. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol (95%)
Substance:

scopoletin (RF-00004048-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Scopoletin

Composition #10: Yang, Cai-xia., Wei, Bin., Wang, Fang-ping., Su, Xiao-long. Study on chemical components from the roots of Stellera chamaejasme L.. tianran chanwu yanjiu yu kaifa, 2012, p. 1374–1376. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol (95%)
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

daphnetin
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Coumarin (daphnetin)

Composition #11: Yang, Cai-xia., Wei, Bin., Wang, Fang-ping., Su, Xiao-long. Study on chemical components from the roots of Stellera chamaejasme L.. tianran chanwu yanjiu yu kaifa, 2012, p. 1374–1376. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol (95%)
Substance:

umbelliferone (RF-00004096-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Umbelliferone

Composition #12: Pi, Li., Hu, Feng-zu., Han, Fa., Xing, Yu-xiu., Zhou, Tong-yong., Deng, Li., Han, Tao. Analysis of chemical components of volatile oil from flower of Tibetan medicine Stellera chamaejasme Linn by gas chromatography-mass spectrometry. shizhen guoyi guoyao, 2012, p. 2404–2405. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Eugenol (RF-00003807-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

9.313
Internal remarks:

Eugenol

Composition #13: Pan, Le., Li, Xiu-zhuang., Yan, Zhi-qiang., Guo, Hong-ru., Qin, Bo. Phytotoxicity of umbelliferone and its analogs: Structure-activity relationships and action mechanisms. Plant Physiology and Biochemistry (Issy-les-Moulineaux, France), 2015, p. 272–277. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Unspecified
Substance:

daphnoretin (RF-00004252-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

daphnoretin

Composition #14: Pan, Le., Li, Xiu-zhuang., Yan, Zhi-qiang., Guo, Hong-ru., Qin, Bo. Phytotoxicity of umbelliferone and its analogs: Structure-activity relationships and action mechanisms. Plant Physiology and Biochemistry (Issy-les-Moulineaux, France), 2015, p. 272–277. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Unspecified
Substance:

umbelliferone (RF-00004096-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

umbelliferone

Endpoint study #1: Zhao, Mengli., Gao, Xinlei., Wang, Jing., He, Xiaolei., Han, Bing. A review of the most economically important poisonous plants to the livestock industry on temperate grasslands of China . journal of applied toxicology, 2013, vol. 33, no. 1, p. 9–17. DOI: 10.1002/jat.2789. [DOI link]

Study relevance:

Animal (target species) health
Plant part:

Live plants (as part-nature) (A0BA0)
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Cattle (as animal) (A057E)
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

Other toxicities (TOX19A)
Effect description:

Poisonous to grazing cattle and sheep, roots and pollen being the most toxic. Acute toxicity including vomiting, abdominal pain, diarrhoea, whole body convulsion, palpitations, hyperthyroidism and possibly death., abortions are also linked to poisoning
Effect or parameter linked to the endpoint:

gross pathology (CHD022BE)
Internal remarks:

Poisonous to grazing animals. Symptoms of acute toxicity include vomiting, abdominal pain, diarrhoea, whole body convulsion, palpitations, hyperthyroidism and possibly death. Abortions are also linked to poisoning.