EFSA Compendium of Botanicals

Draft - work in progress

Spermacoce verticillata L. // Borreria verticillata (L.) G.Mey.

Family:: Rubiaceae
Approval state:: Approved
Number of articles retrieved:: 42
Number of processed references:: 3

Compositions

#1: 1,8 cineol #2: Indole alkaloids (Verticillatine A & B) #3: 2-hydroxy-3-methylanthraquinone

Endpoint Studies

Genotoxicity

Composition #1: Ogunwande, I.A., Walker, T.M., Bansal, A., Setzer, W.N., Essien, E.E. Essential oil constituents and biological activities of Peristrophe bicalyculata and Borreria verticillata. natural product communications, 2010, vol. 5, no. 11, p. 1815–1818. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

20.4
Internal remarks:

1,8 cineol

Composition #2: Moreira, VF., Oliveira, RR., Mathias, L., Braz Filho, R., Vieira, IJC. New Chemical Constituents from Borreria verticillata (Rubiaceae). HELVETICA CHIMICA ACTA, 2010, vol. 93, no. 9, p. 1751–1757. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol extract
Substance:

indole alkaloids (RF-00004503-PAR)
Additional substance description:

Verticillatine A and B
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Indole alkaloids (Verticillatine A & B)

Composition #3: Ferreira Junior, Jesu C., Lyra Lemos, Rosangela P., Conserva, Lucia M. Chemical constituents from Spermacoce verticillata (Rubiaceae). BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2012, vol. 44, p. 208–211. DOI: 10.1016/j.bse.2012.05.011. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 90%
Substance:

anthraquinones (RF-00004343-PAR)
Additional substance description:

2-hydroxy-3-methylanthraquinone
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

IR, EIMS and 1 H and 13C NMR,
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

2-hydroxy-3-methylanthraquinone