EFSA Compendium of Botanicals

Draft - work in progress

Spatholobus suberectus Dunn

Family:: Fabaceae
Approval state:: Approved
Number of articles retrieved:: 471
Number of processed references:: 9

Endpoint Studies

Genotoxicity

Composition #1: Yan, Qixin., Li, Ping., Wang, Di. Study on the liposoluble components of Caulis spatholobi. zhongguo yaoke daxue xuebao, 2001, p. 336–338. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Unspecified solvent, column chromatography
Substance:

chrysophanol (RF-00003737-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Chrysophanol

Composition #2: Yan, Qixin., Li, Ping., Wang, Di. Study on the liposoluble components of Caulis spatholobi. zhongguo yaoke daxue xuebao, 2001, p. 336–338. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Unspecified solvent, column chromatography
Substance:

angelicin (RF-00004146-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Angelicin

Composition #3: Yan, Qixin., Li, Ping., Wang, Di. Study on the liposoluble components of Caulis spatholobi. zhongguo yaoke daxue xuebao, 2001, p. 336–338. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Unspecified solvent, column chromatography
Substance:

physcion (RF-00003993-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Physcion

Composition #4: Lu, Dan., He, Hua., Wu, Bin., Yao, Shanjing. Cytotoxic effect on cancer cells and structural identification of phenols from Spatholobi caulis by HPLC-ESI-MSn. natural product communications, 2009, p. 809–812. .

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethyl acetate/ethanol
Substance:

isoflavones (RF-00004359-PAR)
Additional substance description:

hydroxy-dimethoxy isoflavones, 7-hydroxy-6,2',4'-trimethoxy isoflavone
Analytical method code:

HPLC with standard detection methods (F019A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

hydroxy-dimethoxy isoflavones, 7-hydroxy-6,2',4'-trimethoxy isoflavone

Composition #5: Wang, D.-X., Liu, P., Chen, R.-Y., Chen, M.-L., Chen, G.-Y. Effect of monomers extracted from Spatholobus suberectus Dunn on proliferation of hematopoietic progenitor cells in marrow-depressed mice. journal of clinical rehabilitative tissue engineering research, 2008, vol. 12, no. 21, p. 4163–4166. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethyl acetate
Substance:

Ononin (RF-00011023-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Ononin

Composition #6: Wang, D.-X., Liu, P., Chen, R.-Y., Chen, M.-L., Chen, G.-Y. Effect of monomers extracted from Spatholobus suberectus Dunn on proliferation of hematopoietic progenitor cells in marrow-depressed mice. journal of clinical rehabilitative tissue engineering research, 2008, vol. 12, no. 21, p. 4163–4166. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethyl acetate
Substance:

gallocatechin (RF-00003822-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

gallocatechin

Composition #7: Wang, D.-X., Liu, P., Chen, R.-Y., Chen, M.-L., Chen, G.-Y. Effect of monomers extracted from Spatholobus suberectus Dunn on proliferation of hematopoietic progenitor cells in marrow-depressed mice. journal of clinical rehabilitative tissue engineering research, 2008, vol. 12, no. 21, p. 4163–4166. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethyl acetate
Substance:

furan derivatives (RF-00004396-PAR)
Additional substance description:

pyromucic acid
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

pyromucic acid

Composition #8: Cheng, Y., Fu, Y., Wang, Z., Yang, D., Chen, J., Wang, D. Determination on the contents of condensed tannins in Spatholobus suberectus Dunn. extracts and primary study on their anti-tumor activities. zhongshan daxue xuebao/acta scientiarum natralium universitatis sunyatseni, 2011, vol. 50, no. 2, p. 75–80. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Selective solvent extraction
Substance:

Proanthocyanidins (condensed tannins) Proanthocyanidins (condensed tannins) (RF-00004370-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

29.74-83.11
Internal remarks:

Condensed tannins

Composition #9: Yoon, JS., Sung, SH., Park, JH., Kim, YC. Flavonoids from Spatholobus suberectus. ARCHIVES OF PHARMACAL RESEARCH, 2004, vol. 27, no. 6, p. 589–592. DOI: 10.1007/BF02980154. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

genistein (RF-00000297-NTR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

CD, ELMS, 1D-NMR and 2DNMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Genistein

Composition #10: Yoon, JS., Sung, SH., Park, JH., Kim, YC. Flavonoids from Spatholobus suberectus. ARCHIVES OF PHARMACAL RESEARCH, 2004, vol. 27, no. 6, p. 589–592. DOI: 10.1007/BF02980154. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Medicarpin (RF-00011248-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

CD, ELMS, 1D-NMR and 2DNMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Medicarpin

Composition #11: Yoon, JS., Sung, SH., Park, JH., Kim, YC. Flavonoids from Spatholobus suberectus. ARCHIVES OF PHARMACAL RESEARCH, 2004, vol. 27, no. 6, p. 589–592. DOI: 10.1007/BF02980154. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

isoflavones (RF-00004359-PAR)
Additional substance description:

pseudobaptigenin
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

CD, ELMS, 1D-NMR and 2DNMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

pseudobaptigenin

Composition #12: Yoon, JS., Sung, SH., Park, JH., Kim, YC. Flavonoids from Spatholobus suberectus. ARCHIVES OF PHARMACAL RESEARCH, 2004, vol. 27, no. 6, p. 589–592. DOI: 10.1007/BF02980154. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Pterocarpans (RF-00010808-PAR)
Additional substance description:

(6aR,11aR)-Maackiain
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

CD, ELMS, 1D-NMR and 2DNMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

(6aR,11aR)-Maackiain

Composition #13: Zhang, Shuwei., Xuan, Lijiang. New phenolic constituents from the stems of Spatholobus suberectus. helvetica chimica acta, 2006, vol. 89, no. 6, p. 1241–1245. DOI: 10.1002/hlca.200690121. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

70% acetone
Substance:

Aloe-emodin (RF-00003670-PAR)
Additional substance description:

aloe-emodin and derivatives
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Aloe-emodin and derivatives

Composition #14: Lee, Mei-Hsien., Lin, Yi-Pei., Hsu, Feng-Lin., Zhan, Gui-Rong., Yen, Kun-Ying. Bioactive constituents of Spatholobus suberectus in regulating tyrosinase-related proteins and mRNA in HEMn cells. PHYTOCHEMISTRY, 2006, vol. 67, no. 12, p. 1262–1270. DOI: 10.1016/j.phytochem.2006.05.008. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 95%
Substance:

daidzein (RF-00000061-NTR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

HPLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

daidzein

Composition #15: Lee, Mei-Hsien., Lin, Yi-Pei., Hsu, Feng-Lin., Zhan, Gui-Rong., Yen, Kun-Ying. Bioactive constituents of Spatholobus suberectus in regulating tyrosinase-related proteins and mRNA in HEMn cells. PHYTOCHEMISTRY, 2006, vol. 67, no. 12, p. 1262–1270. DOI: 10.1016/j.phytochem.2006.05.008. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 95%
Substance:

calycosin (RF-00004191-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

HPLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Calycosin

Composition #16: Lee, Mei-Hsien., Lin, Yi-Pei., Hsu, Feng-Lin., Zhan, Gui-Rong., Yen, Kun-Ying. Bioactive constituents of Spatholobus suberectus in regulating tyrosinase-related proteins and mRNA in HEMn cells. PHYTOCHEMISTRY, 2006, vol. 67, no. 12, p. 1262–1270. DOI: 10.1016/j.phytochem.2006.05.008. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 95%
Substance:

formononetin (RF-00000291-NTR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

HPLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

formononetin

Composition #17: Tang, Zhuxing., Zeng, Yikun., Zhou, Yun., He, Pingang., Fang, Yuzhi., Zang, Shuliang. Determination of active ingredients of spatholobus suberectus dunn and its medicinal preparations by capillary electrophoresis with electrochemical detection . journal of liquid chromatography & related technologies, 2007, vol. 30, no. 1, p. 59–71. DOI: 10.1080/10826070601034279. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH (75%)
Substance:

Emodin (RF-00003798-PAR)
Analytical method code:

Capillary (Zone) Electrophoresis (CE or CZE) (F071A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.86
Internal remarks:

Emodin

Composition #18: Tang, Zhuxing., Zeng, Yikun., Zhou, Yun., He, Pingang., Fang, Yuzhi., Zang, Shuliang. Determination of active ingredients of spatholobus suberectus dunn and its medicinal preparations by capillary electrophoresis with electrochemical detection . journal of liquid chromatography & related technologies, 2007, vol. 30, no. 1, p. 59–71. DOI: 10.1080/10826070601034279. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH (75%)
Substance:

rhein (RF-00004027-PAR)
Analytical method code:

Capillary (Zone) Electrophoresis (CE or CZE) (F071A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.75
Internal remarks:

Rhein

Composition #19: Tang Ren-Neng., Qu Xiao-Bo., Guan Shu-Hong., Xu Ping-Ping., Shi Yang-Yang., Guo De-An. Chemical constituents of Spatholobus suberectus. chinese journal of natural medicines, 2012, vol. 10, no. 1, p. 32–35. DOI: 10.3724/SP.J.1009.2012.00032. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH 95% and 70%, column chromatography
Substance:

isoflavones (RF-00004359-PAR)
Additional substance description:

glycyroside
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, ESI-MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Glycyroside

Composition #20: Tang Ren-Neng., Qu Xiao-Bo., Guan Shu-Hong., Xu Ping-Ping., Shi Yang-Yang., Guo De-An. Chemical constituents of Spatholobus suberectus. chinese journal of natural medicines, 2012, vol. 10, no. 1, p. 32–35. DOI: 10.3724/SP.J.1009.2012.00032. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH 95% and 70%, column chromatography
Substance:

medioresinol (RF-00011065-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, ESI-MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Medioresinol

Composition #21: Tang Ren-Neng., Qu Xiao-Bo., Guan Shu-Hong., Xu Ping-Ping., Shi Yang-Yang., Guo De-An. Chemical constituents of Spatholobus suberectus. chinese journal of natural medicines, 2012, vol. 10, no. 1, p. 32–35. DOI: 10.3724/SP.J.1009.2012.00032. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH 95% and 70%, column chromatography
Substance:

isoflavones (RF-00004359-PAR)
Additional substance description:

8-methylretusin-7-O-beta-D-glucopyranoside
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, ESI-MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

8-methylretusin-7-O-beta-D-glucopyranoside