EFSA Compendium of Botanicals

Draft - work in progress

Sparganium stoloniferum (Buch.-Ham. ex Graebn.) Buch.-Ham. ex Juz.

Family:: Typhaceae
Approval state:: Approved
Number of articles retrieved:: 267
Number of processed references:: 5

Compositions

#1: Sparstolonin B #2: 3-isobutyl-tetrahydro-imidazo[1,2-a ]pyridine-2,5-dione #3: Grailsine-Al-glycoside #4: sparganiaside A, 1-O-feruloyl-3- p-coumaroylglycerol

Endpoint Studies

#1: Reproductive toxicity

Genotoxicity

Composition #1: Bateman, Henry R., Liang, Qiaoli., Fan, Daping., Rodriguez, Vanessa., Lessner, Susan M. Sparstolonin B inhibits pro-angiogenic functions and blocks cell cycle progression in endothelial cells. plos one, 2013 . .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Unspecified
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

Sparstolonin B
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Sparstolonin B

Composition #2: Li, Shu-Xian., Wang, Feng., Deng, Xiao-Hui., Liang, Sheng-Wang. A new alkaloid from the stem of Sparganium stoloniferum Buch.-Ham. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2010, vol. 12, no. 4, p. 331–333. DOI: 10.1080/10286021003730330. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

pyridine alkaloids (RF-00010801-PAR)
Additional substance description:

3-isobutyl-tetrahydro-imidazo[1,2-a ]pyridine-2,5-dione
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, IR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

3-isobutyl-tetrahydro-imidazo[1,2-a ]pyridine-2,5-dione

Composition #3: Sun, Jie., Wei, Ya-Hui. A new alkaloid-aluminum glycoside isolated from Rhizoma Sparganii (Sparganium stoloniferum Buch. -Ham.). JOURNAL OF MEDICINAL PLANTS RESEARCH, 2011, vol. 5, no. 14, p. 3128–3131. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water, methanol; column chromatography
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

Grailsine-Al-glycoside
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, Maldi-ToFMS
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

5.99
Internal remarks:

Grailsine-Al-glycoside

Composition #4: Wu, Hao., Feng, Ruihong., Guan, Shuguang., Yu, Wenbo., Man, Wei., Guo, Jiling., Liu, Xuan., Yang, Min., Jiang, Baohong., Wu, Wanying., Zhang, Lianxue., Guan, Shuhong., Guo, Dean. Rapid preparative isolation of a new phenylpropanoid glycoside and four minor compounds from Sparganium stoloniferum using high-speed counter-current chromatography as a fractionation tool . journal of separation science, 2012, vol. 35, no. 9, p. 1160–1166. DOI: 10.1002/jssc.201101073. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH 70%, EtOH 95%; selective extraction
Substance:

phenylpropanoids (RF-00004367-PAR)
Additional substance description:

sparganiaside A, 1-O-feruloyl-3- p-coumaroylglycerol
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

high-speed counter-currentchromatography; HPLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

sparganiaside A, 1-O-feruloyl-3- p-coumaroylglycerol

Endpoint study #1: Sun, Jie., Wang, Shao., Wei, Ya-Hui. Reproductive toxicity of Rhizoma Sparganii (Sparganium stoloniferum Buch.-Ham.) in mice: Mechanisms of anti-angiogenesis and anti-estrogen pharmacologic activities. JOURNAL OF ETHNOPHARMACOLOGY, 2011, vol. 137, no. 3, p. 1498–1503. DOI: 10.1016/j.jep.2011.08.026. [DOI link]

Study relevance:

Human health
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

Water
Type of toxicological test:

reproduction toxicity (CHD009TT)
Limit test:

Not applicable
Tested organism:

House mouse (as animal) (A0CNT)
Strain of test organism:

ICR (CHD044ST)
Sex:

Male/Female
Route of exposure:

ORAL: GAVAGE (OECD2231PL)
Number of organisms dosed:

200
Control groups used:

yes
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligram/kilogram (G061A)
Effect concentration:

400
Critical effect:

REPRODUCTIVE (TOX05A)
Target tissue:

Muscle, Skeletal (TT055A)
Effect description:

umbilical tumors, dysplasia of the phalanges, and reduced mobility
Effect or parameter linked to the endpoint:

morphology (CHD013BE)
Internal remarks:

Reproductive toxicity