EFSA Compendium of Botanicals

Draft - work in progress

Solandra grandiflora Sw.

Family:: Solanaceae
Approval state:: Approved
Number of articles retrieved:: 10
Number of processed references:: 2

Compositions

#1: noratropine #2: tigloidine #3: 3alpha-Tigloyloxytropane #4: 3alpha-Acetoxytropane #5: valtropine #6: hyoscine #7: Littorine #8: atropine #9: tropine #10: Cuscohygrine #11: Hyoscine

Endpoint Studies

Genotoxicity

Composition #1: Evans, W. C., Ghani, A., Woolley, Valerie A. Alkaloids of Solandra species. Phytochemistry (Elsevier), 1972, p. 470–472. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ether extraction
Substance:

Noratropine (RF-00004712-PAR)
Analytical method code:

Chromatographic tests (F015A)
Analytical method - additional description:

column partition chromatography
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.06
Internal remarks:

noratropine

Composition #2: Evans, W. C., Ghani, A., Woolley, Valerie A. Alkaloids of Solandra species. Phytochemistry (Elsevier), 1972, p. 470–472. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ether extraction
Substance:

Tigloidine (RF-00010861-PAR)
Analytical method code:

Chromatographic tests (F015A)
Analytical method - additional description:

column partition chromatography
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.004
Internal remarks:

tigloidine

Composition #3: Evans, W. C., Ghani, A., Woolley, Valerie A. Alkaloids of Solandra species. Phytochemistry (Elsevier), 1972, p. 470–472. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ether extraction
Substance:

3alpha-tigloyloxytropane (RF-00003775-PAR)
Analytical method code:

Chromatographic tests (F015A)
Analytical method - additional description:

column partition chromatography
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.002
Internal remarks:

3alpha-Tigloyloxytropane

Composition #4: Evans, W. C., Ghani, A., Woolley, Valerie A. Alkaloids of Solandra species. Phytochemistry (Elsevier), 1972, p. 470–472. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ether extraction
Substance:

Tropane alkaloids (RF-00000245-TOX)
Additional substance description:

3-Acetoxytropane
Analytical method code:

Chromatographic tests (F015A)
Analytical method - additional description:

column partition chromatography
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.005
Internal remarks:

3alpha-Acetoxytropane

Composition #5: Evans, W. C., Ghani, A., Woolley, Valerie A. Alkaloids of Solandra species. Phytochemistry (Elsevier), 1972, p. 470–472. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ether extraction
Substance:

Valtropine (RF-00010860-PAR)
Analytical method code:

Chromatographic tests (F015A)
Analytical method - additional description:

column partition chromatography
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.004
Internal remarks:

valtropine

Composition #6: Evans, W. C., Ghani, A., Woolley, Valerie A. Alkaloids of Solandra species. Phytochemistry (Elsevier), 1972, p. 470–472. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ether extraction
Substance:

Scopolamine (RF-00000248-TOX)
Additional substance description:

Hyoscine
Analytical method code:

Chromatographic tests (F015A)
Analytical method - additional description:

column partition chromatography
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.004
Internal remarks:

hyoscine

Composition #7: Evans, W. C., Ghani, A., Woolley, Valerie A. Alkaloids of Solandra species. Phytochemistry (Elsevier), 1972, p. 470–472. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ether extraction
Substance:

Littorine (RF-00004711-PAR)
Analytical method code:

Chromatographic tests (F015A)
Analytical method - additional description:

column partition chromatography
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.004
Internal remarks:

Littorine

Composition #8: Evans, W. C., Ghani, A., Woolley, Valerie A. Alkaloids of Solandra species. Phytochemistry (Elsevier), 1972, p. 470–472. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ether extraction
Substance:

Atropine (RF-00000246-TOX)
Analytical method code:

Chromatographic tests (F015A)
Analytical method - additional description:

column partition chromatography
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.08
Internal remarks:

atropine

Composition #9: Evans, W. C., Ghani, A., Woolley, Valerie A. Alkaloids of Solandra species. Phytochemistry (Elsevier), 1972, p. 470–472. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ether extraction
Substance:

tropine (RF-00004093-PAR)
Additional substance description:

as tigloyl ester
Analytical method code:

Chromatographic tests (F015A)
Analytical method - additional description:

column partition chromatography
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

tropine

Composition #10: Evans, W. C., Ghani, A., Woolley, Valerie A. Alkaloids of Solandra species. Phytochemistry (Elsevier), 1972, p. 470–472. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ether extraction
Substance:

cuscohygrine (RF-00003758-PAR)
Analytical method code:

Chromatographic tests (F015A)
Analytical method - additional description:

column partition chromatography
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Cuscohygrine

Composition #11: GHANI, A. METABOLISM OF HYOSCINE FED TO THE AERIAL PARTS OF SOLANDRA-GRANDIFLORA. PLANTA MEDICA, 1980, vol. 38, no. 4, p. 356–358. DOI: 10.1055/s-2008-1074889. [DOI link]

Language:

English (en)
Plant part:

Shoot (as part-nature) (A067T)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ether extraction
Substance:

Scopolamine (RF-00000248-TOX)
Additional substance description:

Hyoscine
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Hyoscine