EFSA
ecomole
vscht
  2. Yacon (as plant) // Smallanthus sonchifolius (Poepp.) H.Rob.

Yacon (as plant) // Smallanthus sonchifolius (Poepp.) H.Rob.

Family:
Asteraceae
Approval state:
Approved
Number of articles retrieved:
630
Number of processed references:
5
Compositions
#1: Sesquiterpene lactones (enhydrin, uvedalin, sonchifolin) #2: sesquiterpene lactones #3: Sesquiterpene lactone (enhydrin) #4: oxalic acid #5: Sequiterpene lactones (leaves) #6: Alkaloids (roots) #7: Alkaloids (leaves) #8: Sequiterpene lactones (roots)
Endpoint Studies
#1: The aqueous extract at 1000 mg/kg bw/day resulted in deaths within 2-3 days. The aqueous extract at 100 mg/kg resulted in hypoactivity and asthenia. Morphological changes in the kidneys were observed at histology. #2: The leaf rinse extract (acetone extraction) at 1000 mg/kg bw/day resulted in deaths within 2-3 days. At 100 mg/kg hypoactivity and asthenia were observed. Histological alterations in the glomeruli, and proximal and distal tubules og the kidneys.
Genotoxicity
Composition #1: Siriwan, D., Miyawaki, C., Miyamoto, T., Naruse, T., Okazaki, K., Tamura, H. Chemopreventive activity of Sesquiterpene Lactones (SLs) from yacon against TPA-induced Raji cells deformation. Pakistan Journal of Biological Sciences, 2011, vol. 14, no. 10, p. 605–609. DOI: 10.3923/pjbs.2011.605.609. [DOI link]
Composition #2: de Oliveira, Rejane Barbosa., Chagas de Paula, Daniela Aparecida., Rocha, Bruno Alves., Franco, Joao Jose., Gobbo-Neto, Leonardo., Uyemura, Sergio Akira., dos Santos, Wagner Ferreira., Da Costa, Fernando Batista. Renal toxicity caused by oral use of medicinal plants: The yacon example. JOURNAL OF ETHNOPHARMACOLOGY, 2011, vol. 133, no. 2, p. 434–441. DOI: 10.1016/j.jep.2010.10.019. [DOI link]
Composition #3: Serra Barcellona, Carolina., Marcelino Cabrera, Wilfredo., Maris Honore, Stella., Ines Mercado, Maria., Serafina Sanchez, Sara., Beatriz Genta, Susana. Safety assessment of aqueous extract from leaf Smallanthus sonchifolius and its main active lactone, enhydrin . journal of ethnopharmacology, 2012, vol. 144, no. 2, p. 362–370. DOI: 10.1016/j.jep.2012.09.021. [DOI link]
Composition #4: Ribeiro Pereira, Juciane de Abreu., Piccolo Barcelos, Maria de Fatima., De Angelis Pereira, Michel Cardoso., Ferreira, Eric Batista. Studies of chemical and enzymatic characteristics of Yacon (Smallanthus sonchifolius) and its flours. FOOD SCIENCE AND TECHNOLOGY, 2013, vol. 33, no. 1, p. 75–83. DOI: 10.1590/S0101-20612013005000020. [DOI link]
Composition #5: Reyes, Charisse T., Villiagen, Robbie-Charles P., Rodriguez, Evelyn B. Phytochemical Screening and Assessment of Health-Related Bioactivities of Phenolic Compounds from Yacon Smallanthus sonchifolius (Poepp. and Endl.) H. Robinson Leaves and Tubers . philippine journal of crop science, 2014, vol. 39, no. 2, p. 1–11. .
Composition #6: Reyes, Charisse T., Villiagen, Robbie-Charles P., Rodriguez, Evelyn B. Phytochemical Screening and Assessment of Health-Related Bioactivities of Phenolic Compounds from Yacon Smallanthus sonchifolius (Poepp. and Endl.) H. Robinson Leaves and Tubers . philippine journal of crop science, 2014, vol. 39, no. 2, p. 1–11. .
Composition #7: Reyes, Charisse T., Villiagen, Robbie-Charles P., Rodriguez, Evelyn B. Phytochemical Screening and Assessment of Health-Related Bioactivities of Phenolic Compounds from Yacon Smallanthus sonchifolius (Poepp. and Endl.) H. Robinson Leaves and Tubers . philippine journal of crop science, 2014, vol. 39, no. 2, p. 1–11. .
Composition #8: Reyes, Charisse T., Villiagen, Robbie-Charles P., Rodriguez, Evelyn B. Phytochemical Screening and Assessment of Health-Related Bioactivities of Phenolic Compounds from Yacon Smallanthus sonchifolius (Poepp. and Endl.) H. Robinson Leaves and Tubers . philippine journal of crop science, 2014, vol. 39, no. 2, p. 1–11. .
Endpoint study #1: de Oliveira, Rejane Barbosa., Chagas de Paula, Daniela Aparecida., Rocha, Bruno Alves., Franco, Joao Jose., Gobbo-Neto, Leonardo., Uyemura, Sergio Akira., dos Santos, Wagner Ferreira., Da Costa, Fernando Batista. Renal toxicity caused by oral use of medicinal plants: The yacon example. JOURNAL OF ETHNOPHARMACOLOGY, 2011, vol. 133, no. 2, p. 434–441. DOI: 10.1016/j.jep.2010.10.019. [DOI link]
Endpoint study #2: de Oliveira, Rejane Barbosa., Chagas de Paula, Daniela Aparecida., Rocha, Bruno Alves., Franco, Joao Jose., Gobbo-Neto, Leonardo., Uyemura, Sergio Akira., dos Santos, Wagner Ferreira., Da Costa, Fernando Batista. Renal toxicity caused by oral use of medicinal plants: The yacon example. JOURNAL OF ETHNOPHARMACOLOGY, 2011, vol. 133, no. 2, p. 434–441. DOI: 10.1016/j.jep.2010.10.019. [DOI link]