EFSA Compendium of Botanicals

Draft - work in progress

Simaba cedron Planch.

Family:: Simaroubaceae
Approval state:: Approved
Number of articles retrieved:: 31
Number of processed references:: 3

Compositions

#1: 1,4- dehirocedronolactone A #2: 7-epi-cedronin in leaves #3: cedronin in seeds #4: quassinoids

Endpoint Studies

Genotoxicity

Composition #1: Osorio-Herrera, Shirley., Gaitan-Ibarra, Ricardo., Diaz-Castillo, Fredyc., Olmedo, Dionisio., Gupta, Mahabir. Isolation and characterization of a novel quassinoid compound from dichlorometane extract of Simaba cedron planch seeds . actualidades biologicas (medellin), 2005, vol. 27, no. Suppl. 1, p. 43–48. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

dichloromethane
Substance:

quassinoids (RF-00004311-PAR)
Additional substance description:

1,4- dehirocedronolactone A
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR+MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

1,4- dehirocedronolactone A

Composition #2: Jacobs, H., Lewis, D.E., Sawyer, J.F., Mclean, S. Cedronin and 7-epi-cedronin: X-ray crystal structure analysis. Journal of Natural Products, 1987, vol. 50, no. 4, p. 700–705. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CHCl3
Substance:

quassinoids (RF-00004311-PAR)
Additional substance description:

7-epi-cedronin
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

melting point, optical rotations, IR, NMR, MS, X-ray
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

7-epi-cedronin in leaves

Composition #3: Jacobs, H., Lewis, D.E., Sawyer, J.F., Mclean, S. Cedronin and 7-epi-cedronin: X-ray crystal structure analysis. Journal of Natural Products, 1987, vol. 50, no. 4, p. 700–705. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CHCl3
Substance:

quassinoids (RF-00004311-PAR)
Additional substance description:

cedronin
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

melting point, optical rotations, IR, NMR, MS, X-ray
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

cedronin in seeds

Composition #4: Ozeki, A., Hitotsuyanagi, Y., Hashimoto, E., Takeya, K., Alves, SD. Cytotoxic quassinoids from Simaba cedron. JOURNAL OF NATURAL PRODUCTS, 1998, vol. 61, no. 6, p. 776–780. DOI: 10.1021/np980023f. [DOI link]

Language:

English (en)
Plant part:

Wood (as part-nature) (A166P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

quassinoids (RF-00004311-PAR)
Additional substance description:

cedronolactones A to D, simalikalactone D, chaparrinone, chaparrin, glaucarubolone, glaucarubol, samaderine Z, guanepolide, ailanquassin A, and polyandrol
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

melting point, UV, IR, NMR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

quassinoids