EFSA
ecomole
vscht
  2. Senna obtusifolia (L.) H.S.Irwin & Barneby // Cassia obtusifolia L.

Senna obtusifolia (L.) H.S.Irwin & Barneby // Cassia obtusifolia L.

Family:
Fabaceae
Approval state:
Approved
Number of articles retrieved:
991
Number of processed references:
9
Compositions
#1: Naphthalene derivatives #2: Physcion #3: Anthraquinone derivatives #4: Anthracene derivatives #5: Oxalates #6: Alkaloids #7: Saponins #8: Aloe-emodin #9: Chrysophanol #10: Physcion #11: Emodin #12: Rhein #13: Obtusifolin‐2‐glucoside #14: Aurantio-obtusin #15: Aloe-emodin #16: Rhein #17: Obtusifolin #18: Emodin #19: Chrysophanol #20: Physcion #21: Emodin #22: Aurantio-obtusin (Anthraquinones) #23: Chrysophanol #24: Aloe-emodin #25: Obtusifolin (Anthraquinones) #26: Rhein
Endpoint Studies
#1: Testicular lesions, hypospermia #2: Bone marrow congestion and depletion #3: Intestine exfoliation of the mucosal epithelium #4: Hepatotoxicity #5: Nephrotoxicity #6: Reluctance to move, muscular weakness, recumbency, pale discoloration of the skeletal muscle. Degeneration and necrosis of the skeletal muscles #7: Degeneration and necrosis of the cardiac muscles (occasionally) #8: Hepatotoxicity #9: Lymphadenopathy
Genotoxicity
Composition #1: Lewis, D. C., Shibamoto, T. Analysis of toxic anthraquinones and related compounds with a fused silica capillary column. HRC CC, Journal of High Resolution Chromatography and Chromatography Communications, 1985, p. 280–282. .
Composition #2: Lewis, D. C., Shibamoto, T. Analysis of toxic anthraquinones and related compounds with a fused silica capillary column. HRC CC, Journal of High Resolution Chromatography and Chromatography Communications, 1985, p. 280–282. .
Composition #3: Lewis, D. C., Shibamoto, T. Analysis of toxic anthraquinones and related compounds with a fused silica capillary column. HRC CC, Journal of High Resolution Chromatography and Chromatography Communications, 1985, p. 280–282. .
Composition #4: Lewis, D. C., Shibamoto, T. Analysis of toxic anthraquinones and related compounds with a fused silica capillary column. HRC CC, Journal of High Resolution Chromatography and Chromatography Communications, 1985, p. 280–282. .
Composition #5: Ingweye, J.N., Kalio, G.A., Ubua, J.A., Umoren, E.P. Nutritional evaluation of wild sicklepod (Senna obtusifolia) seeds from Obanliku, South-Eastern Nigeria. American Journal of Food Technology, 2010, vol. 5, no. 1, p. 1–12. DOI: 10.3923/ajft.2010.1.12. [DOI link]
Composition #6: Ingweye, J.N., Kalio, G.A., Ubua, J.A., Umoren, E.P. Nutritional evaluation of wild sicklepod (Senna obtusifolia) seeds from Obanliku, South-Eastern Nigeria. American Journal of Food Technology, 2010, vol. 5, no. 1, p. 1–12. DOI: 10.3923/ajft.2010.1.12. [DOI link]
Composition #7: Ingweye, J.N., Kalio, G.A., Ubua, J.A., Umoren, E.P. Nutritional evaluation of wild sicklepod (Senna obtusifolia) seeds from Obanliku, South-Eastern Nigeria. American Journal of Food Technology, 2010, vol. 5, no. 1, p. 1–12. DOI: 10.3923/ajft.2010.1.12. [DOI link]
Composition #8: Jiang, TF., Lv, ZH., Wang, YH. Separation and determination of anthraquinones in Cassia obtusifolia (Leguminosae) by micellar electrokinetic capillary electrophoresis . journal of separation science, 2005, vol. 28, no. 16, p. 2225–2229. DOI: 10.1002/jssc.200500144. [DOI link]
Composition #9: Jiang, TF., Lv, ZH., Wang, YH. Separation and determination of anthraquinones in Cassia obtusifolia (Leguminosae) by micellar electrokinetic capillary electrophoresis . journal of separation science, 2005, vol. 28, no. 16, p. 2225–2229. DOI: 10.1002/jssc.200500144. [DOI link]
Composition #10: Jiang, TF., Lv, ZH., Wang, YH. Separation and determination of anthraquinones in Cassia obtusifolia (Leguminosae) by micellar electrokinetic capillary electrophoresis . journal of separation science, 2005, vol. 28, no. 16, p. 2225–2229. DOI: 10.1002/jssc.200500144. [DOI link]
Composition #11: Jiang, TF., Lv, ZH., Wang, YH. Separation and determination of anthraquinones in Cassia obtusifolia (Leguminosae) by micellar electrokinetic capillary electrophoresis . journal of separation science, 2005, vol. 28, no. 16, p. 2225–2229. DOI: 10.1002/jssc.200500144. [DOI link]
Composition #12: Jiang, TF., Lv, ZH., Wang, YH. Separation and determination of anthraquinones in Cassia obtusifolia (Leguminosae) by micellar electrokinetic capillary electrophoresis . journal of separation science, 2005, vol. 28, no. 16, p. 2225–2229. DOI: 10.1002/jssc.200500144. [DOI link]
Composition #13: Xu, Lijia., Chan, Chi-on., Lau, Ching-ching., Yu, Zhiling., Mok, Daniel K. W., Chen, Sibao. Simultaneous Determination of Eight Anthraquinones in Semen Cassiae by HPLC-DAD . phytochemical analysis, 2012, vol. 23, no. 2, p. 110–116. DOI: 10.1002/pca.1331. [DOI link]
Composition #14: Xu, Lijia., Chan, Chi-on., Lau, Ching-ching., Yu, Zhiling., Mok, Daniel K. W., Chen, Sibao. Simultaneous Determination of Eight Anthraquinones in Semen Cassiae by HPLC-DAD . phytochemical analysis, 2012, vol. 23, no. 2, p. 110–116. DOI: 10.1002/pca.1331. [DOI link]
Composition #15: Xu, Lijia., Chan, Chi-on., Lau, Ching-ching., Yu, Zhiling., Mok, Daniel K. W., Chen, Sibao. Simultaneous Determination of Eight Anthraquinones in Semen Cassiae by HPLC-DAD . phytochemical analysis, 2012, vol. 23, no. 2, p. 110–116. DOI: 10.1002/pca.1331. [DOI link]
Composition #16: Xu, Lijia., Chan, Chi-on., Lau, Ching-ching., Yu, Zhiling., Mok, Daniel K. W., Chen, Sibao. Simultaneous Determination of Eight Anthraquinones in Semen Cassiae by HPLC-DAD . phytochemical analysis, 2012, vol. 23, no. 2, p. 110–116. DOI: 10.1002/pca.1331. [DOI link]
Composition #17: Xu, Lijia., Chan, Chi-on., Lau, Ching-ching., Yu, Zhiling., Mok, Daniel K. W., Chen, Sibao. Simultaneous Determination of Eight Anthraquinones in Semen Cassiae by HPLC-DAD . phytochemical analysis, 2012, vol. 23, no. 2, p. 110–116. DOI: 10.1002/pca.1331. [DOI link]
Composition #18: Xu, Lijia., Chan, Chi-on., Lau, Ching-ching., Yu, Zhiling., Mok, Daniel K. W., Chen, Sibao. Simultaneous Determination of Eight Anthraquinones in Semen Cassiae by HPLC-DAD . phytochemical analysis, 2012, vol. 23, no. 2, p. 110–116. DOI: 10.1002/pca.1331. [DOI link]
Composition #19: Xu, Lijia., Chan, Chi-on., Lau, Ching-ching., Yu, Zhiling., Mok, Daniel K. W., Chen, Sibao. Simultaneous Determination of Eight Anthraquinones in Semen Cassiae by HPLC-DAD . phytochemical analysis, 2012, vol. 23, no. 2, p. 110–116. DOI: 10.1002/pca.1331. [DOI link]
Composition #20: Xu, Lijia., Chan, Chi-on., Lau, Ching-ching., Yu, Zhiling., Mok, Daniel K. W., Chen, Sibao. Simultaneous Determination of Eight Anthraquinones in Semen Cassiae by HPLC-DAD . phytochemical analysis, 2012, vol. 23, no. 2, p. 110–116. DOI: 10.1002/pca.1331. [DOI link]
Composition #21: Yang, Chunjuan., Wang, Shuhong., Guo, Xiaowei., Sun, Jiahui., Liu, Lu., Wu, Lijun. Simultaneous determination of seven anthraquinones in rat plasma by Ultra High Performance Liquid Chromatography-tandem Mass Spectrometry and pharmacokinetic study after oral administration of Semen Cassiae extract . journal of ethnopharmacology, 2015, vol. 169, p. 305–313. DOI: 10.1016/j.jep.2015.04.008. [DOI link]
Composition #22: Yang, Chunjuan., Wang, Shuhong., Guo, Xiaowei., Sun, Jiahui., Liu, Lu., Wu, Lijun. Simultaneous determination of seven anthraquinones in rat plasma by Ultra High Performance Liquid Chromatography-tandem Mass Spectrometry and pharmacokinetic study after oral administration of Semen Cassiae extract . journal of ethnopharmacology, 2015, vol. 169, p. 305–313. DOI: 10.1016/j.jep.2015.04.008. [DOI link]
Composition #23: Yang, Chunjuan., Wang, Shuhong., Guo, Xiaowei., Sun, Jiahui., Liu, Lu., Wu, Lijun. Simultaneous determination of seven anthraquinones in rat plasma by Ultra High Performance Liquid Chromatography-tandem Mass Spectrometry and pharmacokinetic study after oral administration of Semen Cassiae extract . journal of ethnopharmacology, 2015, vol. 169, p. 305–313. DOI: 10.1016/j.jep.2015.04.008. [DOI link]
Composition #24: Yang, Chunjuan., Wang, Shuhong., Guo, Xiaowei., Sun, Jiahui., Liu, Lu., Wu, Lijun. Simultaneous determination of seven anthraquinones in rat plasma by Ultra High Performance Liquid Chromatography-tandem Mass Spectrometry and pharmacokinetic study after oral administration of Semen Cassiae extract . journal of ethnopharmacology, 2015, vol. 169, p. 305–313. DOI: 10.1016/j.jep.2015.04.008. [DOI link]
Composition #25: Yang, Chunjuan., Wang, Shuhong., Guo, Xiaowei., Sun, Jiahui., Liu, Lu., Wu, Lijun. Simultaneous determination of seven anthraquinones in rat plasma by Ultra High Performance Liquid Chromatography-tandem Mass Spectrometry and pharmacokinetic study after oral administration of Semen Cassiae extract . journal of ethnopharmacology, 2015, vol. 169, p. 305–313. DOI: 10.1016/j.jep.2015.04.008. [DOI link]
Composition #26: Yang, Chunjuan., Wang, Shuhong., Guo, Xiaowei., Sun, Jiahui., Liu, Lu., Wu, Lijun. Simultaneous determination of seven anthraquinones in rat plasma by Ultra High Performance Liquid Chromatography-tandem Mass Spectrometry and pharmacokinetic study after oral administration of Semen Cassiae extract . journal of ethnopharmacology, 2015, vol. 169, p. 305–313. DOI: 10.1016/j.jep.2015.04.008. [DOI link]
Endpoint study #1: Dugan, G. M., Gumbmann, M. R. Toxicological evaluation of sicklepod and black nightshade seeds in short-​term feeding studies in rats. Food and Chemical Toxicology, 1990, p. 101–107. .
Endpoint study #2: Dugan, G. M., Gumbmann, M. R. Toxicological evaluation of sicklepod and black nightshade seeds in short-​term feeding studies in rats. Food and Chemical Toxicology, 1990, p. 101–107. .
Endpoint study #3: Yagi, SM., El Tigani, S., Adam, SEI. Toxicity of Senna obtusifolia fresh and fermented leaves (kawal), Senna alata leaves and some products from Senna alata on rats. PHYTOTHERAPY RESEARCH, 1998, vol. 12, no. 5, p. 324–330. DOI: 10.1002/(SICI)1099-1573(199808)12:5<324::AID-PTR300>3.0.CO;2-2. [DOI link]
Endpoint study #4: Yagi, SM., El Tigani, S., Adam, SEI. Toxicity of Senna obtusifolia fresh and fermented leaves (kawal), Senna alata leaves and some products from Senna alata on rats. PHYTOTHERAPY RESEARCH, 1998, vol. 12, no. 5, p. 324–330. DOI: 10.1002/(SICI)1099-1573(199808)12:5<324::AID-PTR300>3.0.CO;2-2. [DOI link]
Endpoint study #5: Yagi, SM., El Tigani, S., Adam, SEI. Toxicity of Senna obtusifolia fresh and fermented leaves (kawal), Senna alata leaves and some products from Senna alata on rats. PHYTOTHERAPY RESEARCH, 1998, vol. 12, no. 5, p. 324–330. DOI: 10.1002/(SICI)1099-1573(199808)12:5<324::AID-PTR300>3.0.CO;2-2. [DOI link]
Endpoint study #6: Furlan, Fernando Henrique., Zanata, Carina., Damasceno, Everson dos Santos., de Oliveira, Leonardo Pintar., da Silva, Leilane Aparecida., Colodel, Edson Moleta., Riet-Correa, Franklin. Toxic myopathy and acute hepatic necrosis in cattle caused by ingestion of Senna obtusifolia (sicklepod, coffee senna) in Brazil. TOXICON, 2014, vol. 92, p. 24–30. DOI: 10.1016/j.toxicon.2014.09.007. [DOI link]
Endpoint study #7: Furlan, Fernando Henrique., Zanata, Carina., Damasceno, Everson dos Santos., de Oliveira, Leonardo Pintar., da Silva, Leilane Aparecida., Colodel, Edson Moleta., Riet-Correa, Franklin. Toxic myopathy and acute hepatic necrosis in cattle caused by ingestion of Senna obtusifolia (sicklepod, coffee senna) in Brazil. TOXICON, 2014, vol. 92, p. 24–30. DOI: 10.1016/j.toxicon.2014.09.007. [DOI link]
Endpoint study #8: Furlan, Fernando Henrique., Zanata, Carina., Damasceno, Everson dos Santos., de Oliveira, Leonardo Pintar., da Silva, Leilane Aparecida., Colodel, Edson Moleta., Riet-Correa, Franklin. Toxic myopathy and acute hepatic necrosis in cattle caused by ingestion of Senna obtusifolia (sicklepod, coffee senna) in Brazil. TOXICON, 2014, vol. 92, p. 24–30. DOI: 10.1016/j.toxicon.2014.09.007. [DOI link]
Endpoint study #9: VOSS, KA., BRENNECKE, LH. TOXICOLOGICAL AND HEMATOLOGICAL EFFECTS OF SICKLEPOD (CASSIA-OBTUSIFOLIA) SEEDS IN SPRAGUE-DAWLEY RATS - A SUBCHRONIC FEEDING STUDY. TOXICON, 1991, vol. 29, no. 11, p. 1329–1336. DOI: 10.1016/0041-0101(91)90119-C. [DOI link]