EFSA Compendium of Botanicals

Draft - work in progress

Senna insularis (Britton & Rose) H.S.Irwin & Ba // Cassia absus Sesse & Moc.

Family:: Fabaceae
Approval state:: Approved
Number of articles retrieved:: 135
Number of processed references:: 3

Compositions

Endpoint Studies

#1: A decrease in the fertility index, and an increase in the rate of missed/aborted fetuses observed day 15 after dosing from day 1-5 after mating. No teratogenicity.

Genotoxicity

Composition #1: Siddiqui, Salimuzzaman., Ahmed, Zafaruddhin. Alkaloids from seeds of Cassia absus, Linn. Proceedings - Indian Academy of Sciences, Section A, 1935, p. 421–425. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methyl alcoholic HCl
Substance:

chaksine (RF-00011044-PAR)
Analytical method code:

Traditional analytical techniques (wet chemical tests) (F003A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Chaksine

Composition #2: Pandya, H., Kachwala, Y., Sawant, L., Pandita, N. Pharmacognostical screening of seeds of Cassia absus. Pharmacognosy Journal, 2010, vol. 2, no. 11, p. 419–426. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Hydroalcoholic
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids

Composition #3: Pandya, H., Kachwala, Y., Sawant, L., Pandita, N. Pharmacognostical screening of seeds of Cassia absus. Pharmacognosy Journal, 2010, vol. 2, no. 11, p. 419–426. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Hydro alcoholic
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

saponins

Endpoint study #1: Hamedi, A., Khoshnoud, M.J., Tanideh, N., Abbasi, F., Fereidoonnezhad, M., Mehrabani, D. Reproductive Toxicity of Cassia Absus Seeds in Female Rats: Possible Progesteronic Properties of Chaksine and b-Sitosterol. Pharmaceutical Chemistry Journal, 2015 . DOI: 10.1007/s11094-015-1268-y. [DOI link]

Study relevance:

Human health
Plant part:

Seed (as part-nature) (A066P)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

petroleum ether, n-hexane
Type of toxicological test:

reproduction toxicity (CHD009TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Sprague-Dawley (CHD012ST)
Sex:

Female
Route of exposure:

ORAL: DRINKING WATER (OECD2229PL)
Exposure duration:

5.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

5
Control groups used:

yes, concurrent vehicle
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligrams per kilogram body weight per day (G211A)
Effect concentration:

500
Critical effect:

REPRODUCTIVE (TOX05A)
Target tissue:

urogenital: Uterus (TT052A)
Effect description:

A decrease in the fertility index and an increase in the rate of missed/aborted fetuses but no teratogenicity.
Effect or parameter linked to the endpoint:

reproduction (CHD014BE)
Internal remarks:

A decrease in the fertility index, and an increase in the rate of missed/aborted fetuses observed day 15 after dosing from day 1-5 after mating. No teratogenicity.