EFSA Compendium of Botanicals

Draft - work in progress

Semiaquilegia adoxoides (DC.) Makino

Family:: Ranunculaceae
Approval state:: Approved
Number of articles retrieved:: 80
Number of processed references:: 9

Compositions

#1: 4-[β-D-Apiofuranosyl-( 1→6)-O-β-D-glucopyranosyloxy] phenylacetonitrile #2: thalifendine #3: Furan derivatives #4: lithospermoside (Nitrile glycoside) #5: Magnoflorine #6: 2-(b-D-glucopyranosyloxy)-4-hydroxybenzeneacetonitrile (Nitrile glycoside) #7: lignans ((+)- pinoresinol, (+)-syringaresinol) #8: Diterpene esters (E-semiaquilegin, Z-semiaquilegin) #9: 7-hydroxycoumarin #10: Semiaquilegoside A #11: Benzofuranones (Griffonilide, menisdaurilide, aquilegiolide) #12: Nitrile glucosides ((Z)-6a-(b-D-glucosyloxy)- 4a,5a-dihydroxy-2-cyclohexene-D1 ,a-acetonitrile, lithospermoside, menisdaurin, thalictricoside) #13: Isoquinoline alkaloid (Semiaquilegine A) #14: 5-Hydroxymethyl furfural #15: Four benzoic acid derivatives

Endpoint Studies

Genotoxicity

Composition #1: Niu, Feng., Xie, Guang-bo., Cui, Zheng., Chen, Fa-kui., Tu, Peng-fei. Chemical constituents from roots of Semiaquilegia adoxoides. Journal of Chinese Pharmaceutical Sciences, 2006, p. 251–254. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

95% ethanol
Substance:

Nitrile glycosides Nitrile glycosides (RF-00010843-PAR)
Additional substance description:

4-[β-D-Apiofuranosyl-( 1→6)-O-β-D-glucopyranosyloxy] phenylacetonitrile
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

melting point, NMR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

4-[β-D-Apiofuranosyl-( 1→6)-O-β-D-glucopyranosyloxy] phenylacetonitrile

Composition #2: Niu, Feng., Xie, Guang-bo., Cui, Zheng., Chen, Fa-kui., Tu, Peng-fei. Chemical constituents from roots of Semiaquilegia adoxoides. Journal of Chinese Pharmaceutical Sciences, 2006, p. 251–254. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

95% ethanol
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

Thalifendine (berberine alkaloid)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

melting point, NMR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

thalifendine

Composition #3: Zou, J.-H., Yang, J.-S. Study on chemical constituents isolated from Semiaquilegia adoxoides. chinese pharmaceutical journal, 2004, vol. 39, no. 4, p. 256–257. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Additional extraction description:

unspecified
Substance:

furan derivatives (RF-00004396-PAR)
Additional substance description:

cirsiumaldehyde, griffonilide
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Furan derivatives

Composition #4: Zou, J.-H., Yang, J.-S. Study on chemical constituents isolated from Semiaquilegia adoxoides. chinese pharmaceutical journal, 2004, vol. 39, no. 4, p. 256–257. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Additional extraction description:

unspecified
Substance:

Nitrile glycosides Nitrile glycosides (RF-00010843-PAR)
Additional substance description:

lithospermoside
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

lithospermoside (Nitrile glycoside)

Composition #5: Han, QB., Jiang, B., Mei, SX., Ding, G., Sun, HD., Xie, JX., Liu, YZ. Constituents from the roots of Semiaquilegia adoxoides. fitoterapia, 2001, vol. 72, no. 1, p. 86–88. DOI: 10.1016/S0367-326X(00)00242-2. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Additional extraction description:

unspecified
Substance:

magnoflorine (RF-00003919-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Magnoflorine

Composition #6: Su, YF., Zhang, ZC., Guo, CY., Guo, DA. A novel cyanogenic glycoside from Semiaquilegia adoxoides. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2005, vol. 7, no. 2, p. 171–174. DOI: 10.1080/10286020310001625148. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

95% ethanol
Substance:

Nitrile glycosides Nitrile glycosides (RF-00010843-PAR)
Additional substance description:

2-(b-D-glucopyranosyloxy)-4-hydroxybenzeneacetonitrile
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

melting point, optical rotations, IR, NMR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

2-(b-D-glucopyranosyloxy)-4-hydroxybenzeneacetonitrile (Nitrile glycoside)

Composition #7: Niu, Feng., Chang, Hai-Tao., Jiang, Yong., Cui, Zheng., Chen, Fa-Kui., Yuan, Jiu-Zhi., Tu, Peng-Fei. New diterpenoids from Semiaquilegia adoxoides. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2006, vol. 8, no. 1-2, p. 87–91. DOI: 10.1080/10286020500381464. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

95% ethanol
Substance:

lignans (RF-00004361-PAR)
Additional substance description:

(+)- pinoresinol, (+)-syringaresinol
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

melting point, optical rotations, IR, NMR, MS, UV
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

lignans ((+)- pinoresinol, (+)-syringaresinol)

Composition #8: Niu, Feng., Chang, Hai-Tao., Jiang, Yong., Cui, Zheng., Chen, Fa-Kui., Yuan, Jiu-Zhi., Tu, Peng-Fei. New diterpenoids from Semiaquilegia adoxoides. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2006, vol. 8, no. 1-2, p. 87–91. DOI: 10.1080/10286020500381464. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

95% ethanol
Substance:

Diterpene esters (RF-00010831-PAR)
Additional substance description:

E-semiaquilegin, Z-semiaquilegin
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

melting point, optical rotations, IR, NMR, MS, UV
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Diterpene esters (E-semiaquilegin, Z-semiaquilegin)

Composition #9: Niu, Feng., Chang, Hai-Tao., Jiang, Yong., Cui, Zheng., Chen, Fa-Kui., Yuan, Jiu-Zhi., Tu, Peng-Fei. New diterpenoids from Semiaquilegia adoxoides. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2006, vol. 8, no. 1-2, p. 87–91. DOI: 10.1080/10286020500381464. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

95% ethanol
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

7- hydroxycoumarin
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

melting point, optical rotations, IR, NMR, MS, UV
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

7-hydroxycoumarin

Composition #10: Niu, Feng., Cui, Zheng., Li, Qin., Chang, Haitao., Jiang, Yong., Qiaoi, Liang., Tu, Peng-fei. Complete assignments of H-1 and C-13 NMR spectral data for a novel diterpenoid from Semiaquilegia adoxoides . magnetic resonance in chemistry, 2006, vol. 44, no. 7, p. 724–726. DOI: 10.1002/mrc.1812. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

95% ethanol
Substance:

Diterpene ketones (RF-00010828-PAR)
Additional substance description:

Semiaquilegoside A
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Semiaquilegoside A

Composition #11: Niu, Feng., Niu, Zhanqi., Xie, Guangbo., Meng, Fang., Zhang, Guoen., Cui, Zheng., Tu, Pengfei. Development of an HPLC fingerprint for quality control of radix semiaquilegiae . chromatographia, 2006, vol. 64, no. 9-10, p. 593–597. DOI: 10.1365/s10337-006-0069-6. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

furan derivatives (RF-00004396-PAR)
Additional substance description:

benzofuranones (Griffonilide, menisdaurilide, aquilegiolide)
Analytical method code:

HPLC-DAD (F587A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Benzofuranones (Griffonilide, menisdaurilide, aquilegiolide)

Composition #12: Niu, Feng., Niu, Zhanqi., Xie, Guangbo., Meng, Fang., Zhang, Guoen., Cui, Zheng., Tu, Pengfei. Development of an HPLC fingerprint for quality control of radix semiaquilegiae . chromatographia, 2006, vol. 64, no. 9-10, p. 593–597. DOI: 10.1365/s10337-006-0069-6. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

Nitrile glycosides Nitrile glycosides (RF-00010843-PAR)
Additional substance description:

(Z)-6a-(b-D-glucosyloxy)- 4a,5a-dihydroxy-2-cyclohexene-D1 ,a-acetonitrile, lithospermoside, menisdaurin, thalictricoside
Analytical method code:

HPLC-DAD (F587A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Nitrile glucosides ((Z)-6a-(b-D-glucosyloxy)- 4a,5a-dihydroxy-2-cyclohexene-D1 ,a-acetonitrile, lithospermoside, menisdaurin, thalictricoside)

Composition #13: Niu Feng., Cui Zheng., Chang Hai-Tao., Jiang Yong., Chen Fa-Kui., Tu Peng-Fei. Constituents from the roots of Semiaquilegia adoxoides. CHINESE JOURNAL OF CHEMISTRY, 2006, vol. 24, no. 12, p. 1788–1791. DOI: 10.1002/cjoc.200690334. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

95% ethanol
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

Semiaquilegine A
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

melting point, UV, IR, NMR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isoquinoline alkaloid (Semiaquilegine A)

Composition #14: Niu Feng., Cui Zheng., Chang Hai-Tao., Jiang Yong., Chen Fa-Kui., Tu Peng-Fei. Constituents from the roots of Semiaquilegia adoxoides. CHINESE JOURNAL OF CHEMISTRY, 2006, vol. 24, no. 12, p. 1788–1791. DOI: 10.1002/cjoc.200690334. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

95% ethanol
Substance:

Hydroxymethylfurfural (RF-00000379-ORG)
Additional substance description:

5-Hydroxymethyl furfural
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

melting point, UV, IR, NMR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

5-Hydroxymethyl furfural

Composition #15: Lee, Chia-Lin., Hwang, Tsong-Long., Peng, Chieh-Yu., Chen, Chao-Jung., Chang, Yuan-Shiun., Wu, Yang-Chang. Anti-neutrophilic Inflammatory Secondary Metabolites from the Traditional Chinese Medicine, Tiankuizi . natural product communications, 2012, vol. 7, no. 12, p. 1623–1626. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Additional extraction description:

unspecified
Substance:

Benzoic acid (RF-00000052-ADD)
Additional substance description:

benzoic acid derivatives incl. 4-Hydroxybenzoic acid and 3,4-dihyroxybenzoic acid
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Four benzoic acid derivatives