EFSA Compendium of Botanicals

Draft - work in progress

Selaginella doederleinii Hieron.

Family:: Selaginellaceae
Approval state:: Approved
Number of articles retrieved:: 85
Number of processed references:: 7

Compositions

#1: Isopimpinellin #2: Alkaloids (berberine and palmatine) #3: Gallic acid #4: Oxalates #5: Eucalyptol #6: Dibenzofuran #7: 2-pentyl-furan #8: Hordenine and glycoside derivatives #9: Phenylpropanones #10: Lignans

Endpoint Studies

#1: hypertensive activityfter oral administration of hordenine and glycosidic derivatives

Genotoxicity

Composition #1: Chen, Ping., Sun, Jingyun., Xie, Niangeng., Shi, Yingu. Chemical constituents of dayecai (Selaginella doederleinii). zhongcaoyao, 1995, p. 397–399. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Additional extraction description:

unspecified
Substance:

Isopimpinellin (RF-00003784-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isopimpinellin

Composition #2: Zhao, Q., Wang, C.-X., Li, Y.-L., Liu, C.-Y., Rong, Y.-H. Chemical constituents from Selaginella doederleinii and their bioactivities. chinese traditional and herbal drugs, 2013, vol. 44, no. 23, p. 3270–3275. DOI: 10.7501/j.issn.0253-2670.2013.23.004. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

BuOH
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

berberine and palmatine
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids (berberine and palmatine)

Composition #3: Zhao, Q., Wang, C.-X., Li, Y.-L., Liu, C.-Y., Rong, Y.-H. Chemical constituents from Selaginella doederleinii and their bioactivities. chinese traditional and herbal drugs, 2013, vol. 44, no. 23, p. 3270–3275. DOI: 10.7501/j.issn.0253-2670.2013.23.004. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOAc
Substance:

gallic acid (RF-00003821-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Gallic acid

Composition #4: Huang James., Huang Chris., Liebman Michael. Oxalate contents of commonly used Chinese medicinal herbs. journal of traditional chinese medicine = chung i tsa chih ying wen pan / sponsored by all-china association of traditional chinese medicine, academy of traditional chinese medicine, 2015, p. 594–599. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

acid and water extraction
Substance:

Oxalates (RF-00004308-PAR)
Analytical method code:

Enzymatic tests (F069A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

71
Internal remarks:

Oxalates

Composition #5: Wang Gang., Song Hang., Yao Shun., Zhang Zhi Rong., Sung, WP., Zhang, CZ., Chen, R. Analysis of Volatile Oil in Selaginella doederleinii Hieron from Various Habitats by GC-MS . biotechnology, chemical and materials engineering ii, pts 1 and 2, 2013, vol. 641-642, p. 862–866. DOI: 10.4028/www.scientific.net/AMR.641-642.862. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

microwave assisted extraction
Substance:

1,8-cineole (RF-00003470-PAR)
Additional substance description:

eucalyptol
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.37-1.52
Internal remarks:

Eucalyptol

Composition #6: Wang Gang., Song Hang., Yao Shun., Zhang Zhi Rong., Sung, WP., Zhang, CZ., Chen, R. Analysis of Volatile Oil in Selaginella doederleinii Hieron from Various Habitats by GC-MS . biotechnology, chemical and materials engineering ii, pts 1 and 2, 2013, vol. 641-642, p. 862–866. DOI: 10.4028/www.scientific.net/AMR.641-642.862. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

microwave assisted extraction
Substance:

furan derivatives (RF-00004396-PAR)
Additional substance description:

dibenzofuran
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.19-1.99
Internal remarks:

Dibenzofuran

Composition #7: Wang Gang., Song Hang., Yao Shun., Zhang Zhi Rong., Sung, WP., Zhang, CZ., Chen, R. Analysis of Volatile Oil in Selaginella doederleinii Hieron from Various Habitats by GC-MS . biotechnology, chemical and materials engineering ii, pts 1 and 2, 2013, vol. 641-642, p. 862–866. DOI: 10.4028/www.scientific.net/AMR.641-642.862. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

microwave assisted extraction
Substance:

2-Pentylfuran (RF-00008482-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.14-4.35
Internal remarks:

2-pentyl-furan

Composition #8: CHAO, LR., SEGUIN, E., TILLEQUIN, F., KOCH, M. NEW ALKALOID GLYCOSIDES FROM SELAGINELLA-DOEDERLEINII. JOURNAL OF NATURAL PRODUCTS, 1987, vol. 50, no. 3, p. 422–426. DOI: 10.1021/np50051a013. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol Extraction
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

Hordenine and glycoside derivatives
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Hordenine and glycoside derivatives

Composition #9: LIN, RC., SKALTSOUNIS, AL., SEGUIN, E., TILLEQUIN, F., KOCH, M. PHENOLIC CONSTITUENTS OF SELAGINELLA-DOEDERLEINII. planta medica, 1994, vol. 60, no. 2, p. 168–170. DOI: 10.1055/s-2006-959443. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

phenylpropanoids (RF-00004367-PAR)
Additional substance description:

phenylpropanones
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Phenylpropanones

Composition #10: LIN, RC., SKALTSOUNIS, AL., SEGUIN, E., TILLEQUIN, F., KOCH, M. PHENOLIC CONSTITUENTS OF SELAGINELLA-DOEDERLEINII. planta medica, 1994, vol. 60, no. 2, p. 168–170. DOI: 10.1055/s-2006-959443. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

lignans (RF-00004361-PAR)
Additional substance description:

(-)-lirioresinol A, (-)-lirioresinol B, (+)-wikstromol, (-)-nortracheloside, (+)-matairesinol
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lignans

Endpoint study #1: LIN, RC., PEYROUX, J., SEGUIN, E., KOCH, M. HYPERTENSIVE EFFECT OF GLYCOSIDIC DERIVATIVES OF HORDENINE ISOLATED FROM SELAGINELLA-DOEDERLEINII HIERON AND STRUCTURAL ANALOGS IN RATS. PHYTOTHERAPY RESEARCH, 1991, vol. 5, no. 4, p. 188–190. DOI: 10.1002/ptr.2650050412. [DOI link]

Study relevance:

Human health
Substance:

hordenine (RF-00003427-PAR)
Plant part:

Unspecified (A07XD)
Additional plant/substance description:

hordenine and glycoside derivatives
Type of toxicological test:

acute toxicity (CHD016TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Sprague-Dawley (CHD012ST)
Sex:

Male
Route of exposure:

ORAL: FEED (OECD2230PL)
Exposure duration:

180.0
Unit of exposure duration:

Minute (G074A)
Control groups used:

yes
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligram/kilogram (G061A)
Effect concentration:

1
Critical effect:

PULMONARY AND CARDIAC (TOX08A)
Target tissue:

cardiovascular / haematological: Heart (TT011A)
Effect description:

hypertensive activity after oral administration of hordenine and its glycosidic derivatives
Effect or parameter linked to the endpoint:

other (CHD003BE)
Internal remarks:

hypertensive activityfter oral administration of hordenine and glycosidic derivatives