EFSA Compendium of Botanicals

Endpoint study #1: Aslani, Mohammad Reza., Movassaghi, Ahmad Reza., Najarnezhad, Vahid., Pirouz, Hossein Janati., Bami, Mohammad Heidarpour. Acute oxalate intoxication associated to ingestion of eshnan (Seidlitzia rosmarinus) in sheep. TROPICAL ANIMAL HEALTH AND PRODUCTION, 2011, vol. 43, no. 6, p. 1065–1068. DOI: 10.1007/s11250-011-9818-0. [DOI link]

Study relevance:

Human health
Substance:

Oxalates (RF-00004308-PAR)
Plant part:

Bud (as part-nature) (A066Z)
Preparation/Extraction method:

Fresh (A166Y)
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Sheep (as animal) (A057G)
Sex:

Male/Female
Route of exposure:

ORAL: FEED (OECD2230PL)
Number of organisms dosed:

900
Control groups used:

no
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

SYSTEMIC (TOX01A)
Target tissue:

urogenital: Kidneys (TT046A)
Effect description:

Congestion of subcutaneous tissues, hemorrhages on rumen mucosa and GI tract, hydrothorax, hydropericardium, pulmonary edema and hemorrhage. Kidneys swollen and congested; heavy deposit of oxalate crystals in the cortical and medullary tubules of kidneys
Effect or parameter linked to the endpoint:

mortality (CHD010BE)
Internal remarks:

Nephrototoxicity + other adverse effects

Seidlitzia rosmarinus Bunge ex Boiss. // Salsola rosmarinus (Ehrenb. ex Boiss.) Akhani