EFSA Compendium of Botanicals

Draft - work in progress

Sedum aizoon L.

Family:: Crassulaceae
Approval state:: Approved
Number of articles retrieved:: 169
Number of processed references:: 7

Compositions

#1: Piperidine alkaloids ((t)-methylisopelletierine, (-)-sedinine, (t)-sedamine) #2: Alkaloids (Roots) #3: Alkaloids (Aerial part) #4: Coumarins (Roots) #5: Coumarins (Aerial part) #6: Tannins (Aerial part) #7: Tannins (Roots) #8: Hydroquinone #9: Pyrrolizidine alkaloids #10: 2-Acetylnaphthalene #11: Sedacin A and B (isoflavones) #12: gallic acid #13: p-hydroxybenzoic acid #14: protocatechuic acid

Endpoint Studies

#1: Hepatotoxicity (hepatic veno occlusive disease)

Genotoxicity

Composition #1: Krasnov, E. A., Petrova, L. V., Bekker, E. F. Alkaloids of Sedum species. khimiya prirodnykh soedinenii, 1977 . .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Additional extraction description:

unspecified
Substance:

Piperidine alkaloids (RF-00004320-PAR)
Additional substance description:

(t)-methylisopelletierine, (-)-sedinine, (t)-sedamine
Analytical method code:

Chromatographic tests (F015A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Piperidine alkaloids ((t)-methylisopelletierine, (-)-sedinine, (t)-sedamine)

Composition #2: Korul'kin, D. Yu. Chemical composition of certain Sedum species of Kazakhstan. Chemistry of Natural Compounds (Translation of Khimiya Prirodnykh Soedinenii), 2001, p. 219–223. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

acetone
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.2
Internal remarks:

Alkaloids (Roots)

Composition #3: Korul'kin, D. Yu. Chemical composition of certain Sedum species of Kazakhstan. Chemistry of Natural Compounds (Translation of Khimiya Prirodnykh Soedinenii), 2001, p. 219–223. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

acetone
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.35
Internal remarks:

Alkaloids (Aerial part)

Composition #4: Korul'kin, D. Yu. Chemical composition of certain Sedum species of Kazakhstan. Chemistry of Natural Compounds (Translation of Khimiya Prirodnykh Soedinenii), 2001, p. 219–223. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

acetone
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

7-hydroxycoumarin
Analytical method code:

Phytochemical screening (F604A)
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.3
Internal remarks:

Coumarins (Roots)

Composition #5: Korul'kin, D. Yu. Chemical composition of certain Sedum species of Kazakhstan. Chemistry of Natural Compounds (Translation of Khimiya Prirodnykh Soedinenii), 2001, p. 219–223. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

acetone
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

7-hydroxycoumarin
Analytical method code:

Phytochemical screening (F604A)
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.2
Internal remarks:

Coumarins (Aerial part)

Composition #6: Korul'kin, D. Yu. Chemical composition of certain Sedum species of Kazakhstan. Chemistry of Natural Compounds (Translation of Khimiya Prirodnykh Soedinenii), 2001, p. 219–223. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

acetone
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

11.5
Internal remarks:

Tannins (Aerial part)

Composition #7: Korul'kin, D. Yu. Chemical composition of certain Sedum species of Kazakhstan. Chemistry of Natural Compounds (Translation of Khimiya Prirodnykh Soedinenii), 2001, p. 219–223. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

acetone
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

22.8
Internal remarks:

Tannins (Roots)

Composition #8: Korul'kin, D. Yu. Chemical composition of certain Sedum species of Kazakhstan. Chemistry of Natural Compounds (Translation of Khimiya Prirodnykh Soedinenii), 2001, p. 219–223. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

acetone
Substance:

Hydroquinone (RF-00007127-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Hydroquinone

Composition #9: Gao, Xinsheng., Xiao, Shaoshu., He, Jiangfu. Analysis of alkaloids in Sedum aizoon and establishment of hepatic veno-occlusive model in mice. zhongguo zhongxiyi jiehe xiaohua zazhi, 2006, p. 311–313. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Additional extraction description:

unspecified
Substance:

Pyrrolizidine alkaloids (RF-00000230-TOX)
Additional substance description:

senecionine, seneciphylline and integerrimine - Plant misidentification according to R2 and R3
Analytical method code:

GC-MS (F046A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Pyrrolizidine alkaloids

Composition #10: Lin, Zhu-can., Huang, Hua-hua., Chen, Da-wei., Chen, Jian-wei., Guo, Su-hua. Study on chemical constituents of active parts of calming the heart and tranquilizing the mind from Sedum aizoon L.. zhonghua zhongyiyao zazhi, 2011, p. 3000–3002. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Naphthalene derivatives (RF-00010833-PAR)
Additional substance description:

2-Acetylnaphthalene
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

2-Acetylnaphthalene

Composition #11: Li, Wei Lin., Luo, Qiu Yan., Wu, Li Qiang. Two new prenylated isoflavones from Sedum aizoon L.. fitoterapia, 2011, vol. 82, no. 3, p. 405–407. DOI: 10.1016/j.fitote.2010.11.021. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

isoflavones (RF-00004359-PAR)
Additional substance description:

sedacin A and B
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Sedacin A and B (isoflavones)

Composition #12: Lin, Zhucan., Fang, Yingjuan., Huang, Anyu., Chen, Liyun., Guo, Suhua., Chen, Jianwei. Chemical constituents from Sedum aizoon and their hemostatic activity. pharmaceutical biology, 2014, vol. 52, no. 11, p. 1429–1434. DOI: 10.3109/13880209.2014.895019. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water
Substance:

gallic acid (RF-00003821-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

gallic acid

Composition #13: Lin, Zhucan., Fang, Yingjuan., Huang, Anyu., Chen, Liyun., Guo, Suhua., Chen, Jianwei. Chemical constituents from Sedum aizoon and their hemostatic activity. pharmaceutical biology, 2014, vol. 52, no. 11, p. 1429–1434. DOI: 10.3109/13880209.2014.895019. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water
Substance:

4-Hydroxybenzoic acid (RF-00008325-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

p-hydroxybenzoic acid

Composition #14: Lin, Zhucan., Fang, Yingjuan., Huang, Anyu., Chen, Liyun., Guo, Suhua., Chen, Jianwei. Chemical constituents from Sedum aizoon and their hemostatic activity. pharmaceutical biology, 2014, vol. 52, no. 11, p. 1429–1434. DOI: 10.3109/13880209.2014.895019. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water
Substance:

3,4-Dihydroxybenzoic acid (RF-00008853-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

protocatechuic acid

Endpoint study #1: Wu, Guo-Lin., Yu, Guo-You., Chen, Jiu. Clinical analysis of hepatic veno-occlusive disease induced by Sedum aizoon . . zhongguo zhong yao za zhi = zhongguo zhongyao zazhi = china journal of chinese materia medica, 2008, vol. 33, no. 20, p. 2402–4. .

Study relevance:

Human health
Plant part:

Unspecified (A07XD)
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Human (as organism) (A056J)
Sex:

No data
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

HEPATOTOXICITY (TOX02A)
Target tissue:

digestive: Liver (TT023A)
Effect description:

hepatic veno-occlusive disease induced by Sedum aizoon
Effect or parameter linked to the endpoint:

not reported (CHD030BE)
Internal remarks:

Hepatotoxicity (hepatic veno occlusive disease)