EFSA Compendium of Botanicals

Draft - work in progress

Scutellaria lateriflora L.

Family:: Lamiaceae (Labiatae)
Approval state:: Approved
Number of articles retrieved:: 179
Number of processed references:: 4

Compositions

#1: Clerodane diterpenes (scutelaterins A-C, ajugapitin and scutecyprol A) #2: Coumarins (scuteflorins A and B, decursin) #3: Lignan ((+)-syringaresinol 4'-O-beta-D-glucopyranoside)

Endpoint Studies

#1: Significant dose-dependent increase in skeletal variations and in incidence of abnormal urinary system #2: Alpha-glucosidase inhibition

Genotoxicity

Composition #1: Bruno, M., Cruciata, M., Bondi, ML., Piozzi, F., de la Torre, MC., Rodriguez, B., Servettaz, O. Neo-clerodane diterpenoids from Scutellaria lateriflora. PHYTOCHEMISTRY, 1998, vol. 48, no. 4, p. 687–691. DOI: 10.1016/S0031-9422(97)01032-7. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Acetone
Substance:

clerodane-type diterpenes (RF-00004350-PAR)
Additional substance description:

scutelaterins A-C, ajugapitin and scutecyprol A
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Clerodane diterpenes (scutelaterins A-C, ajugapitin and scutecyprol A)

Composition #2: Li, Jing., Ding, Yuanqing., Li, Xing-Cong., Ferreira, Daneel., Khan, Shabana., Smillie, Troy., Khan, Ikhlas A. Scuteflorins A and B, Dihydropyranocoumarins from Scutellaria lateriflora . journal of natural products, 2009, vol. 72, no. 6, p. 983–987. DOI: 10.1021/np900068t. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

scuteflorins A and B, decursin
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

UV, IR, HRESIMS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Coumarins (scuteflorins A and B, decursin)

Composition #3: Kuroda, Minpei., Iwabuchi, Katsura., Mimaki, Yoshihiro. Chemical Constituents of the Aerial Parts of Scutellaria lateriflora and their alpha-Glucosidase Inhibitory Activities . natural product communications, 2012, vol. 7, no. 4, p. 471–474. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

lignans (RF-00004361-PAR)
Additional substance description:

(+)-syringaresinol 4'-O-beta-D-glucopyranoside
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lignan ((+)-syringaresinol 4'-O-beta-D-glucopyranoside)

Endpoint study #1: Jurgens, TM. Potential Toxicities of herbal therapies in the developing fetus. birth defects research part b-developmental and reproductive toxicology, 2003, vol. 68, no. 6, p. 496–498. DOI: 10.1002/bdrb.10050. [DOI link]

Study relevance:

Human health
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Additional plant/substance description:

unspecified
Type of toxicological test:

reproduction toxicity (CHD009TT)
Tested organism:

Rat (as animal) (A0CNV)
Sex:

No data
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Exposure duration:

7.0
Unit of exposure duration:

Day (G134A)
Control groups used:

no data
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

REPRODUCTIVE (TOX05A)
Target tissue:

Urogenital (TT006A)
Effect description:

significant dose-dependent increase in skeletal variations and in incidence of abnormal urinary system
Effect or parameter linked to the endpoint:

reproduction (CHD014BE)
Internal remarks:

Significant dose-dependent increase in skeletal variations and in incidence of abnormal urinary system

Endpoint study #2: Kuroda, Minpei., Iwabuchi, Katsura., Mimaki, Yoshihiro. Chemical Constituents of the Aerial Parts of Scutellaria lateriflora and their alpha-Glucosidase Inhibitory Activities . natural product communications, 2012, vol. 7, no. 4, p. 471–474. .

Study relevance:

Human health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

methanol extract
Type of toxicological test:

in vitro (CHD061TT)
Tested organism:

Rat (as animal) (A0CNV)
Sex:

No data
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

The MeOH extract of the aerial parts of Scutellaria lateriflora L. (Lamiaceae) significantly inhibited sucrase and maltase activities, using sucrose and maltase as the substrates
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

Alpha-glucosidase inhibition