EFSA Compendium of Botanicals

Draft - work in progress

Scutellaria barbata D.Don

Family:: Lamiaceae
Approval state:: Approved
Number of articles retrieved:: 897
Number of processed references:: 10

Compositions

#1: Diterpene lactone (neoandrographolide) #2: Syringaresinol #3: Physcion (anthraquinone) #4: 4-Hydroxybenzaldehyde #5: 6-hydroxycoumarin #6: Isocarthamidine (isoquinoline alkaloid) #7: Ombuoside (coumarin) #8: Diterpene alkaloids (scutebarbatines) #9: Pheophorbide a #10: Diterpene alkaloids #11: Diterpene alkaloids (scutebarbatine O and 6-Onicotinoylscutebarbatine G) #12: Eugenol #13: 1-Hydroxynaphthalene #14: Methyleugenol #15: 2,3-Dihydrobenzofuran

Endpoint Studies

Genotoxicity

Composition #1: Zhu, Pinye., Liu, Guoqiao. Isolation and identification of the diterpenoid and flavone in Scutellaria barbata D. Don. zhiwu ziyuan yu huanjing, 1993, p. 63–64. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Additional extraction description:

unspecified
Substance:

diterpene lactones (RF-00004306-PAR)
Additional substance description:

neoandrographolide
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Diterpene lactone (neoandrographolide)

Composition #2: Li, Ping., Zhang, Guo-gang., Zuo, Tian-tian., Wang, Sheng-chao. Chemical constituents of the whole plant of Scutellaria barbata D. Don. shenyang yaoke daxue xuebao, 2008, p. 549–552. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Additional extraction description:

unspecified
Substance:

syringaresinol (RF-00011386-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Syringaresinol

Composition #3: Li, Ping., Zhang, Guo-gang., Zuo, Tian-tian., Wang, Sheng-chao. Chemical constituents of the whole plant of Scutellaria barbata D. Don. shenyang yaoke daxue xuebao, 2008, p. 549–552. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Additional extraction description:

unspecified
Substance:

physcion (RF-00003993-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Physcion (anthraquinone)

Composition #4: Zhong, Hao., Xue, Xiaoxia., Yao, Qingqiang. Chemical constituents of Scutellaria barbata. zhongcaoyao, 2008, p. 21–23. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Additional extraction description:

unspecified
Substance:

4-Hydroxybenzaldehyde (RF-00001976-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

4-Hydroxybenzaldehyde

Composition #5: Chen, Yan., Zhang, Guogang., Mao, Deshuang., Li, Yingna. Chemical constituents of Scutellaria barbata D. Don (I). zhongguo yaowu huaxue zazhi, 2008, p. 48–50. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Additional extraction description:

unspecified
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

6-hydroxycoumarin
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

6-hydroxycoumarin

Composition #6: Chen, Yan., Zhang, Guogang., Mao, Deshuang., Li, Yingna. Chemical constituents of Scutellaria barbata D. Don (I). zhongguo yaowu huaxue zazhi, 2008, p. 48–50. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Additional extraction description:

unspecified
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

isocarthamidine
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isocarthamidine (isoquinoline alkaloid)

Composition #7: Zhang, Yi., He, Shuheng., Ge, Dandan., Zhang, Peng., Gao, Xiumei., Wang, Tao. Isolation and identification of chemical constituents from whole plant of Scutellaria barbata D. Don (II). shenyang yaoke daxue xuebao, 2011, p. 425–428. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Additional extraction description:

unspecified
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

ombuoside
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Ombuoside (coumarin)

Composition #8: Gong Tao., Yuan Jia-Rui., Li Yu., Gu Jun-Fei., Zhao Bing-Jie., Jia Xiao-Bin., Wang Chun-Fei., Zhang Li., Feng Liang., Liu Shen-Lin. Inhibition of Tumor Growth and Immunomodulatory Effects of Flavonoids and Scutebarbatines of Scutellaria barbata D. Don in Lewis-Bearing C57BL/6 Mice. evidence-based complementary and alternative medicine : ecam, 2015 . .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water
Substance:

Diterpene alkaloids (RF-00004377-PAR)
Additional substance description:

scutebarbatines
Analytical method code:

UHPLC-MS-MS (F608A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Diterpene alkaloids (scutebarbatines)

Composition #9: Tang, Patrick Ming-Kuen., Chan, Judy Yuet-Wa., Au, Shannon Wing-Ngor., Kong, Siu-Kai., Tsui, Stephen Kwok-Wing., Waye, Mary Mui-Yee., Mak, Thomas Chung-Wai., Fong, Wing-Ping., Fung, Kwok-Pui. Pheophorbide a, an active compound isolated from Scutellaria barbata, possesses photodynamic activities by inducing apoptosis in human hepatocellular carcinoma . cancer biology & therapy, 2006, vol. 5, no. 9, p. 1111–1116. DOI: 10.4161/cbt.5.9.2950. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Additional extraction description:

unspecified
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

Pheophorbide a (tetrapyrrole)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Pheophorbide a

Composition #10: Dai, Sheng-Jun., Wang, Gong-Fu., Chen, Meng., Liu, Ke., Shen, Li. Five new neo-clerodane diterpenoid alkaloids from Scutellaria barbata with cytotoxic activities . chemical & pharmaceutical bulletin, 2007, vol. 55, no. 8, p. 1218–1221. DOI: 10.1248/cpb.55.1218. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH
Substance:

Diterpene alkaloids (RF-00004377-PAR)
Additional substance description:

scutebarbatine G, 6,7-di-O-nicotinoylscutebarbatine G, 6-O-nicotinoyl-7-O-acetylscutebarbatine G, scutebarbatine H and 7-O-nicotinoylscutebarbatine H
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Diterpene alkaloids

Composition #11: Dai, Sheng-Jun., Peng, Wei-Bing., Shen, Li., Zhang, De-Wu., Ren, Yan. Two new neo-clerodane diterpenoid alkaloids from Scutellaria barbata with cytotoxic activities. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2009, vol. 11, no. 5, p. 451–456. DOI: 10.1080/10286020902845652. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

Diterpene alkaloids (RF-00004377-PAR)
Additional substance description:

scutebarbatine O and 6-Onicotinoylscutebarbatine G
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Diterpene alkaloids (scutebarbatine O and 6-Onicotinoylscutebarbatine G)

Composition #12: Yang, Ji-Yeon., Kim, Min-Gi., Lee, Hoi-Seon. Acaricidal Toxicities of 1-Hydroxynaphthalene from Scutellaria barbata and Its Derivatives against House Dust and Storage Mites . planta medica, 2013, vol. 79, no. 11, p. 946–951. DOI: 10.1055/s-0032-1328631. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

steam distillation
Substance:

Eugenol (RF-00003807-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.74
Internal remarks:

Eugenol

Composition #13: Yang, Ji-Yeon., Kim, Min-Gi., Lee, Hoi-Seon. Acaricidal Toxicities of 1-Hydroxynaphthalene from Scutellaria barbata and Its Derivatives against House Dust and Storage Mites . planta medica, 2013, vol. 79, no. 11, p. 946–951. DOI: 10.1055/s-0032-1328631. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

steam distillation
Substance:

Naphthalene derivatives (RF-00010833-PAR)
Additional substance description:

1-Hydroxynaphthalene
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

12.22
Internal remarks:

1-Hydroxynaphthalene

Composition #14: Yang, Ji-Yeon., Kim, Min-Gi., Lee, Hoi-Seon. Acaricidal Toxicities of 1-Hydroxynaphthalene from Scutellaria barbata and Its Derivatives against House Dust and Storage Mites . planta medica, 2013, vol. 79, no. 11, p. 946–951. DOI: 10.1055/s-0032-1328631. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

steam distillation
Substance:

methyleugenol (RF-00003931-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.13
Internal remarks:

Methyleugenol

Composition #15: Yang, Ji-Yeon., Kim, Min-Gi., Lee, Hoi-Seon. Acaricidal Toxicities of 1-Hydroxynaphthalene from Scutellaria barbata and Its Derivatives against House Dust and Storage Mites . planta medica, 2013, vol. 79, no. 11, p. 946–951. DOI: 10.1055/s-0032-1328631. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

steam distillation
Substance:

furan derivatives (RF-00004396-PAR)
Additional substance description:

2,3-Dihydrobenzofuran
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.56
Internal remarks:

2,3-Dihydrobenzofuran