EFSA Compendium of Botanicals

Draft - work in progress

Scrophularia ningpoensis Helmsl.

Family:: Scrophulariaceae
Approval state:: Approved
Number of articles retrieved:: 459
Number of processed references:: 5

Compositions

#1: Clematomandshurica saponin E #2: Alpha-cedrol #3: Veratrum alkaloids #4: Methylisoeugenol #5: Eugenol #6: Scrophularianines A–C #7: Phenylpropanoid (Scrophuside)

Endpoint Studies

Genotoxicity

Composition #1: Li, Yuan., Song, Baoan., Yang, Song., Hu, Deyu., Jin, Linhong. Chemical constituents of Scrophularia ningpoensis Hemsl.. tianran chanwu yanjiu yu kaifa, 2012, p. 47–51. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

pentacyclic triterpene saponins (RF-00004334-PAR)
Additional substance description:

Clematomandshurica saponin E
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Clematomandshurica saponin E

Composition #2: Li, Yuan., Song, Baoan., Yang, Song., Hu, Deyu., Jin, Linhong. Chemical constituents of Scrophularia ningpoensis Hemsl.. tianran chanwu yanjiu yu kaifa, 2012, p. 47–51. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

alpha-cedrol (RF-00003645-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alpha-cedrol

Composition #3: Zhang, J., Ip, F.C.F., Tong, E.P.S., Chan, K.W., Li, L.-C., Ng, Y.P., Ip, N.Y. Ningpoensines A-C: Unusual zwitterionic alkaloids from Scrophularia ningpoensis. Tetrahedron Letters, 2015, vol. 56, no. 40, p. 5453–5456. DOI: 10.1016/j.tetlet.2015.08.021. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH (70%)
Substance:

veratrum alkaloids (RF-00010813-PAR)
Additional substance description:

Ningpoensines A, B, C
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Veratrum alkaloids

Composition #4: Xue, Gang-qiang., Du, Jing., Pan, Xin-yan., Gao, Hui., Sun, Zhi-yong., Zhang, Yang., Gao, Shu-li. Chemical constituents of Scrophularia ningpoensis root .. zhong yao cai = zhongyaocai = journal of chinese medicinal materials, 2014, vol. 37, no. 9, p. 1597–9. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Additional extraction description:

Unspecified
Substance:

methylisoeugenol (RF-00003493-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Methylisoeugenol

Composition #5: Xue, Gang-qiang., Du, Jing., Pan, Xin-yan., Gao, Hui., Sun, Zhi-yong., Zhang, Yang., Gao, Shu-li. Chemical constituents of Scrophularia ningpoensis root .. zhong yao cai = zhongyaocai = journal of chinese medicinal materials, 2014, vol. 37, no. 9, p. 1597–9. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Additional extraction description:

Unspecified
Substance:

Eugenol (RF-00003807-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Eugenol

Composition #6: Zhu, Ling-Juan., Hou, Yun-Long., Shen, Xiu-Yu., Pan, Xiao-Dong., Zhang, Xue., Yao, Xin-Sheng. Monoterpene pyridine alkaloids and phenolics from Scrophularia ningpoensis and their cardioprotective effect . fitoterapia, 2013, vol. 88, p. 44–49. DOI: 10.1016/j.fitote.2013.04.005. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 70%
Substance:

pyridine alkaloids (RF-00010801-PAR)
Additional substance description:

Scrophularianines A–C
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Scrophularianines A–C

Composition #7: Hua, Jing., Qi, Jin., Yu, Bo-Yang. lridoid and phenylpropanoid glycosides from Scrophularia ningpoensis Hemsl. and their alpha-Glucosidase inhibitory activities. FITOTERAPIA, 2014, vol. 93, p. 67–73. DOI: 10.1016/j.fitote.2013.11.011. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH (80%)
Substance:

phenylpropanoids (RF-00004367-PAR)
Additional substance description:

Scrophuside
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Phenylpropanoid (Scrophuside)