EFSA Compendium of Botanicals

Draft - work in progress

Sarcopoterium spinosum (L.) Spach

Family:: Rosaceae
Approval state:: Approved
Number of articles retrieved:: 164
Number of processed references:: 2

Compositions

Endpoint Studies

#1: Dual inhibition of alpha-amylase and alpha-glucosidase

Genotoxicity

Composition #1: Reher, G., Slijepcevic, M., Kraus Lj. Hypoglycemic activity of triterpenes and tannins from Sarcopoterium spinosum and two Sanguisorba species. Planta Medica, 1991, vol. 57, no. SUPPL. 2, p. A57–A58. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Additional extraction description:

root bark extract
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tannins

Endpoint study #1: Kasabri, Violet., Afifi, Fatma U., Hamdan, Imad. In vitro and in vivo acute antihyperglycemic effects of five selected indigenous plants from Jordan used in traditional medicine . journal of ethnopharmacology, 2011, vol. 133, no. 2, p. 888–896. DOI: 10.1016/j.jep.2010.11.025. [DOI link]

Study relevance:

Human health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

water extract
Type of toxicological test:

in vitro (CHD061TT)
Route of exposure:

OTHER (OECD0PL)
Control groups used:

no data
Endpoint measured:

Half maximal inhibitory concentration (CHD021EP)
Concentration unit:

Milligram/millilitre (G191A)
Effect concentration:

49.9
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

Dual inhibition of alpha-amylase and alpha-glucosidase
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

Dual inhibition of alpha-amylase and alpha-glucosidase