EFSA Compendium of Botanicals

Draft - work in progress

Saraca asoca (Roxb.) Willd.

Family:: Fabaceae
Approval state:: Approved
Number of articles retrieved:: 141
Number of processed references:: 8

Compositions

#1: Lignans #2: Tannins #3: Anthraquinones #4: Saponins #5: Methylsalicylate #6: Salicylates #7: Lignans #8: Tannins #9: Thujone #10: Gallic acid

Endpoint Studies

#1: Dietary administration of methanol extract of bark powder lowered serum levels of HDL-cholesterol by 43.6%

Genotoxicity

Composition #1: Ahmed, F., Sadhu, S.K., Ishibashi, M. Search for bioactive natural products from medicinal plants of Bangladesh. journal of natural medicines, 2010, vol. 64, no. 4, p. 393–401. DOI: 10.1007/s11418-010-0424-7. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

lignans (RF-00004361-PAR)
Additional substance description:

Lignan glycosides (lyoniside,;nudiposide; 5-methoxy-9-b-xylopyranosyl-(-)-isolariciresinol; icariside E3; and schizandriside)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lignans

Composition #2: Mukhopadhyay, M.K., Nath, D. Phytochemical screening and toxicity study of Saraca asoca bark methanolic extract. international journal of phytomedicine, 2011, vol. 3, no. 4, p. 498–505. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tannins

Composition #3: Mukhopadhyay, M.K., Nath, D. Phytochemical screening and toxicity study of Saraca asoca bark methanolic extract. international journal of phytomedicine, 2011, vol. 3, no. 4, p. 498–505. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

anthraquinones (RF-00004343-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Anthraquinones

Composition #4: Mukhopadhyay, M.K., Nath, D. Phytochemical screening and toxicity study of Saraca asoca bark methanolic extract. international journal of phytomedicine, 2011, vol. 3, no. 4, p. 498–505. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Saponins

Composition #5: Joshi, R.K. E,E-α-Farnesene rich essential oil of Saraca asoca (Roxb.) Wilde flower. natural product research, 2015 . DOI: 10.1080/14786419.2015.1076818. [DOI link]

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistilled oil
Substance:

methyl salicylate (RF-00003930-PAR)
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

also GC-FID
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

9.5
Internal remarks:

Methylsalicylate

Composition #6: Gupta Mradu., Sasmal Saumyakanti., Mukherjee Arup. Therapeutic Effects of Acetone Extract of Saraca asoca Seeds on Rats with Adjuvant-Induced Arthritis via Attenuating Inflammatory Responses. isrn rheumatology, 2014 . .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

acetone
Substance:

Salicylates (RF-00004331-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Salicylates

Composition #7: Mittal, Ashwani., Kadyan, Preeti., Gahlaut, Anjum., Dabur, Rajesh. Nontargeted Identification of the Phenolic and Other Compounds of Saraca asoca by High Performance Liquid Chromatography-Positive Electrospray Ionization and Quadrupole Time-of-Flight Mass Spectrometry.. ISRN pharmaceutics, 2013, vol. 2013, p. 293935–293935. DOI: 10.1155/2013/293935. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

lignans (RF-00004361-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

HPLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lignans

Composition #8: Mittal, Ashwani., Kadyan, Preeti., Gahlaut, Anjum., Dabur, Rajesh. Nontargeted Identification of the Phenolic and Other Compounds of Saraca asoca by High Performance Liquid Chromatography-Positive Electrospray Ionization and Quadrupole Time-of-Flight Mass Spectrometry.. ISRN pharmaceutics, 2013, vol. 2013, p. 293935–293935. DOI: 10.1155/2013/293935. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

HPLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tannins

Composition #9: Singh, Arundhati., Singh, V. K. Molluscicidal activity of Saraca asoca and Thuja orientalis against the fresh water snail Lymnaea acuminata . veterinary parasitology, 2009, vol. 164, no. 2-4, p. 206–210. DOI: 10.1016/j.vetpar.2009.05.008. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

alpha-thujone (RF-00003676-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Thujone

Composition #10: Aeri, Vidhu., Mishra, Shikha. Evaluation of Pre- and Post-Fermented Aqueous Decoction of Saraca asoca by High-Performance Thin-Layer Chromatography . jpc-journal of planar chromatography-modern tlc, 2015, vol. 28, no. 1, p. 36–41. DOI: 10.1556/JPC.28.2015.1.6. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hot water extraction
Substance:

gallic acid (RF-00003821-PAR)
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Gallic acid

Endpoint study #1: Nasrin, D., Moushumi, S.J., Ahmed, R., Nahar, N., Ahsan, S., Khatun, A., Jamal, F., Chowdhury, M.H., Rahmatullah, M. An evaluation of administration in diet of Saraca asoca (Roxb.) De Wilde bark extract on serum lipid profiles in rats. advances in natural and applied sciences, 2010, vol. 4, no. 3, p. 382–384. .

Study relevance:

Human health
Plant part:

Bark (as part-nature) (A066X)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

methanol extract
Type of toxicological test:

short-term toxicity (CHD017TT)
Tested organism:

Rat (as animal) (A0CNV)
Route of exposure:

ORAL: FEED (OECD2230PL)
Exposure duration:

14.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

12
Control groups used:

yes
Endpoint measured:

Concentration level (CHD013EP)
Concentration unit:

Milligram/kilogram (G061A)
Effect concentration:

500
Critical effect:

PULMONARY AND CARDIAC (TOX08A)
Target tissue:

Cardiovascular / Haematological (TT001A)
Effect description:

Dietary administration of methanol extract of bark powder lowered serum levels of HDL-cholesterol by 43.6%
Effect or parameter linked to the endpoint:

not reported (CHD030BE)
Internal remarks:

Dietary administration of methanol extract of bark powder lowered serum levels of HDL-cholesterol by 43.6%