Draft - work in progress
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- Patience dock (as plant) // Rumex patientia L.
Patience dock (as plant) // Rumex patientia L.
- Family:
- Polygonaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 197
- Number of processed references:
- 7
Composition #1: Schlemmer, F., Gentner, O. Pharmaceutical-chemical investigations on Rumex alpinus L. and Rumex patientia L. archiv der pharmazie und berichte der deutschen pharmazeutischen gesellschaft, 1940, p. 252–283. .
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Plant part:
Unspecified (A07XD)
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Substance:
Tannins (RF-00004337-PAR)
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Additional substance description:
cathecol tannin glucosides
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Analytical method code:
Unspecified (F598A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Catechol Tannin glycoside in Rumex patietia
Composition #2: Gao, Liming., Wei, Xiaomei., Zheng, Shangzhen., Shen, Xuwei., Su, Yaozeng. Studies on chemical constituents of Rumex patientia. zhongcaoyao, 2002, p. 207–209. .
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Plant part:
Unspecified (A07XD)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
unspecified
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Substance:
lignans (RF-00004361-PAR)
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Additional substance description:
arctiin, 3-hydroxy-arctiin and 3-methoxyacrtiin-4"-O-beta-D-xyloside
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Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Lignans
Composition #3: Guinot, Pauline., Roge, Aline., Gargadennec, Annick., Garcia, Michel., Dupont, Daniel., Lecoeur, Edwige., Candelier, Laurent., Andary, Claude. Dyeing plants screening: an approach to combine past heritage and present development. Coloration Technology, 2006, p. 93–101. .
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
deionised water
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Substance:
Tannins (RF-00004337-PAR)
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Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
tannins in roots
Composition #4: Yuan, Y., Chen, W.-S., Zheng, S.-Q., Yang, G.-J., Zhang, W.-D., Zhang, H.-M. Studies on chemical constituents in root of Rumex patientia L.. zhongguo zhongyao zazhi, 2001, vol. 26, no. 4, p. 257–258. .
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
unspecifid
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Substance:
furan derivatives (RF-00004396-PAR)
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Additional substance description:
5-methoxy-7-hydroxy-1(3H)-benzofuranone, 5,7-dihydroxy-1(3H)-benzofuranone
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Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Furan derivatives in roots
Composition #5: Yuan, Y., Chen, W.-S., Zheng, S.-Q., Yang, G.-J., Zhang, W.-D., Zhang, H.-M. Studies on chemical constituents in root of Rumex patientia L.. zhongguo zhongyao zazhi, 2001, vol. 26, no. 4, p. 257–258. .
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
unspecifid
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Substance:
gallic acid (RF-00003821-PAR)
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Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Gallic acid in roots
Composition #6: Zeng, Yong., Luo, Jian-Jun., Li, Chong. Chemical constituents from aerial part of Rumex patientia .. zhong yao cai = zhongyaocai = journal of chinese medicinal materials, 2013, vol. 36, no. 1, p. 57–60. .
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Plant part:
Aerial part of plants (as part-nature) (A166F)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
unspecified
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Substance:
anthraquinones (RF-00004343-PAR)
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Additional substance description:
chrysophanol, chrysophanol-8-O-beta-D-glucopyranoside, physcion , emodin, emodin-8-O-beta-D-glucopyranoside
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Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Anthraquinones ( chrysophanol, chrysophanol-8-O-beta-D-glucopyranoside , physcion , emodin and emodin-8-O-beta-D-glucopyranoside) in the aerial part,
Composition #7: Zeng, Yong., Luo, Jian-Jun., Li, Chong. Chemical constituents from aerial part of Rumex patientia .. zhong yao cai = zhongyaocai = journal of chinese medicinal materials, 2013, vol. 36, no. 1, p. 57–60. .
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Plant part:
Aerial part of plants (as part-nature) (A166F)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
unspecified
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Substance:
Naphthalene derivatives (RF-00010833-PAR)
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Additional substance description:
Nepodin-8-O-beta-D-glucopyranoside and Torachysone-8-O-beta-D-glucopyranoside
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Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Naphtalene derivatives ( torachrysone-8-O-beta-D-glucopyranoside and nepodin-8-O-beta-D-glucopyranoside) .
Composition #8: Zeng, Yong., Luo, Jian-Jun., Li, Chong. Chemical constituents from aerial part of Rumex patientia .. zhong yao cai = zhongyaocai = journal of chinese medicinal materials, 2013, vol. 36, no. 1, p. 57–60. .
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Plant part:
Aerial part of plants (as part-nature) (A166F)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
unspecified
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Substance:
isoflavones (RF-00004359-PAR)
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Additional substance description:
maackiain and maackiain-3-O-beta-D- glucopyranoside
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Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Isoflavones ( maackiain and maackiain-3-O-beta-D- glucopyranoside) in the aerial part
Composition #9: Demirezer, LO., Kuruuzum-Uz, A., Bergere, I., Schiewe, HJ., Zeeck, A. The structures of antioxidant and cytotoxic agents from natural source: anthraquinones and tannins from roots of Rumex patientia . phytochemistry, 2001, vol. 58, no. 8, p. 1213–1217. DOI: 10.1016/S0031-9422(01)00337-5.
[
DOI link]
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
water
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Substance:
Emodin (RF-00003798-PAR)
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Additional substance description:
emodin-6-O-beta--D-glucopyranoside
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Analytical method - additional description:
NMR + ESI-MS
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Emodin-6-O-beta-D-glucopyrnoside in root
Composition #10: Islam, Rabigul., Mamat, Yultuz., Ismayil, Ilyar., Yan, Ming., Kadir, Mahsutjan., Abdugheny, Abdujilil., Rapkat, Haximjan., Niyaz, Mardan., Ali, Yusupjan., Abay, Sirapil. Toxicity of Anthraquinones: Differential Effects of Rumex Seed Extracts on Rat Organ Weights and Biochemical and Haematological Parameters. PHYTOTHERAPY RESEARCH, 2015, vol. 29, no. 5, p. 777–784. DOI: 10.1002/ptr.5317.
[
DOI link]
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Plant part:
Seed (as part-nature) (A066P)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Water and ethanol
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Substance:
chrysophanol (RF-00003737-PAR)
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
chrysophanol (anthraquinone) in seeds
Composition #11: Islam, Rabigul., Mamat, Yultuz., Ismayil, Ilyar., Yan, Ming., Kadir, Mahsutjan., Abdugheny, Abdujilil., Rapkat, Haximjan., Niyaz, Mardan., Ali, Yusupjan., Abay, Sirapil. Toxicity of Anthraquinones: Differential Effects of Rumex Seed Extracts on Rat Organ Weights and Biochemical and Haematological Parameters. PHYTOTHERAPY RESEARCH, 2015, vol. 29, no. 5, p. 777–784. DOI: 10.1002/ptr.5317.
[
DOI link]
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Plant part:
Seed (as part-nature) (A066P)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Water and ethanol
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Substance:
Emodin (RF-00003798-PAR)
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Emodin (anthraquinone) in seeds
Endpoint study
#1: Islam, Rabigul., Mamat, Yultuz., Ismayil, Ilyar., Yan, Ming., Kadir, Mahsutjan., Abdugheny, Abdujilil., Rapkat, Haximjan., Niyaz, Mardan., Ali, Yusupjan., Abay, Sirapil. Toxicity of Anthraquinones: Differential Effects of Rumex Seed Extracts on Rat Organ Weights and Biochemical and Haematological Parameters. PHYTOTHERAPY RESEARCH, 2015, vol. 29, no. 5, p. 777–784. DOI: 10.1002/ptr.5317.
[
DOI link]
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Study relevance:
Human health
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Substance:
anthraquinones (RF-00004343-PAR)
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Plant part:
Seed (as part-nature) (A066P)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
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Additional plant/substance description:
Ethanol and water
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Type of toxicological test:
chronic/long term toxicity (CHD004TT)
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Tested organism:
Rat (as animal) (A0CNV)
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Route of exposure:
ORAL: FEED (OECD2230PL)
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Unit of exposure duration:
Week (G205A)
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Endpoint measured:
Dose level (CHD014EP)
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Concentration unit:
Milligram/kilogram (G061A)
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Effect concentration:
4000
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Critical effect:
HEPATOTOXICITY (TOX02A)
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Target tissue:
digestive: Liver (TT023A)
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Effect description:
Gross histopathological changes in the liver where infiltration of inflammatory cells, necrosis, steatosis and oedema were observed
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Effect or parameter linked to the endpoint:
histopathology non neoplastic (CHD025BE)
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Internal remarks:
Administration of R. patientia seed anthraquinone-rich extracts caused gross histopathological changes in the liver
Endpoint study
#2: Islam, Rabigul., Mamat, Yultuz., Ismayil, Ilyar., Yan, Ming., Kadir, Mahsutjan., Abdugheny, Abdujilil., Rapkat, Haximjan., Niyaz, Mardan., Ali, Yusupjan., Abay, Sirapil. Toxicity of Anthraquinones: Differential Effects of Rumex Seed Extracts on Rat Organ Weights and Biochemical and Haematological Parameters. PHYTOTHERAPY RESEARCH, 2015, vol. 29, no. 5, p. 777–784. DOI: 10.1002/ptr.5317.
[
DOI link]
-
Study relevance:
Human health
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Substance:
anthraquinones (RF-00004343-PAR)
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Plant part:
Seed (as part-nature) (A066P)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
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Additional plant/substance description:
Ethanol and water
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Type of toxicological test:
chronic/long term toxicity (CHD004TT)
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Tested organism:
Rat (as animal) (A0CNV)
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Route of exposure:
ORAL: FEED (OECD2230PL)
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Unit of exposure duration:
Week (G205A)
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Endpoint measured:
Dose level (CHD014EP)
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Concentration unit:
Milligram/kilogram (G061A)
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Effect concentration:
4000
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Critical effect:
PULMONARY AND CARDIAC (TOX08A)
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Target tissue:
respiratory: Lung (TT041A)
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Effect description:
Gross histopathological changes in the lung where infiltration of inflammatory cells, necrosis, steatosis and oedema were observed
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Effect or parameter linked to the endpoint:
histopathology non neoplastic (CHD025BE)
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Internal remarks:
Administration of R. patientia seed anthraquinone-rich extracts caused gross histopathological changes in the lung
Endpoint study
#3: Islam, Rabigul., Mamat, Yultuz., Ismayil, Ilyar., Yan, Ming., Kadir, Mahsutjan., Abdugheny, Abdujilil., Rapkat, Haximjan., Niyaz, Mardan., Ali, Yusupjan., Abay, Sirapil. Toxicity of Anthraquinones: Differential Effects of Rumex Seed Extracts on Rat Organ Weights and Biochemical and Haematological Parameters. PHYTOTHERAPY RESEARCH, 2015, vol. 29, no. 5, p. 777–784. DOI: 10.1002/ptr.5317.
[
DOI link]
-
Study relevance:
Human health
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Substance:
anthraquinones (RF-00004343-PAR)
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Plant part:
Seed (as part-nature) (A066P)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
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Additional plant/substance description:
Ethanol and water
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Type of toxicological test:
chronic/long term toxicity (CHD004TT)
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Tested organism:
Rat (as animal) (A0CNV)
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Route of exposure:
ORAL: FEED (OECD2230PL)
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-
Unit of exposure duration:
Week (G205A)
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-
Endpoint measured:
Dose level (CHD014EP)
-
Concentration unit:
Milligram/kilogram (G061A)
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Effect concentration:
4000
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Critical effect:
NEPHROTOXICITY (TOX03A)
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Target tissue:
urogenital: Kidneys (TT046A)
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Effect description:
Gross histopathological changes in the kidneys where infiltration of inflammatory cells, necrosis, steatosis and oedema were observed
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Effect or parameter linked to the endpoint:
histopathology non neoplastic (CHD025BE)
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Internal remarks:
Administration of R. patientia seed anthraquinone-rich extracts caused gross histopathological changes in the kidneys