EFSA Compendium of Botanicals

Draft - work in progress

Ruellia tuberosa L.

Family:: Acanthaceae
Approval state:: Approved
Number of articles retrieved:: 107
Number of processed references:: 3

Compositions

#1: Saponins in roots #2: Alkaloids in roots #3: Saponins in inflorescences #4: Alkaloids in shoots #5: Tannins

Endpoint Studies

Genotoxicity

Composition #1: Sinha, S. K. P., Dogra, J. V. V. A survey of the plants of Bhagalpur and Santhal Pargana for saponin, flavonoids and alkaloids. international journal of crude drug research, 1985, p. 77–86. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

redistilled methylated spirit
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Saponins in roots

Composition #2: Sinha, S. K. P., Dogra, J. V. V. A survey of the plants of Bhagalpur and Santhal Pargana for saponin, flavonoids and alkaloids. international journal of crude drug research, 1985, p. 77–86. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

redistilled methylated spirit
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids in roots

Composition #3: Sinha, S. K. P., Dogra, J. V. V. A survey of the plants of Bhagalpur and Santhal Pargana for saponin, flavonoids and alkaloids. international journal of crude drug research, 1985, p. 77–86. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

redistilled methylated spirit
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Saponins in inflorescences

Composition #4: Sinha, S. K. P., Dogra, J. V. V. A survey of the plants of Bhagalpur and Santhal Pargana for saponin, flavonoids and alkaloids. international journal of crude drug research, 1985, p. 77–86. .

Language:

English (en)
Plant part:

Shoot (as part-nature) (A067T)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

redistilled methylated spirit
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids in shoots

Composition #5: Arirudran, B., Saraswathy, A., Krishnamurthy, V. Pharmacognostic and preliminary phytochemical studies on Ruellia tuberosa L. (whole plant). Pharmacognosy Journal, 2011, vol. 3, no. 22, p. 29–34. DOI: 10.5530/pj.2011.22.6. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

alcohol, EtOAc, H2O
Substance:

Tannins (RF-00004337-PAR)
Additional substance description:
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tannins

Endpoint study #1: Ratna Wulan, Dyah., Priyo Utomo, Edi., Mahdi, Chanif. Antidiabetic Activity of Ruellia tuberosa L., Role of alpha-Amylase Inhibitor: In Silico, In Vitro, and In Vivo Approaches. . biochemistry research international, 2015, vol. 2015, p. 349261. DOI: 10.1155/2015/349261. [DOI link]

Study relevance:

Human health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

n-hexane fraction of methanolic extract
Type of toxicological test:

in vitro (CHD061TT)
Control groups used:

yes
Endpoint measured:

Half maximal inhibitory concentration (CHD021EP)
Concentration unit:

Milligram/millilitre (G191A)
Effect concentration:

0.14
Critical effect:

Digestive (TOX18A)
Target tissue:

urogenital: Urinary Bladder (TT051A)
Effect description:

alpha-amylase inhibition; A single dose administration of HFME inhibited 𝛼-amylase activity in vivo (𝑃 < 0.01) compared to a diabetic control group
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

alpha-amylase inhibition