EFSA Compendium of Botanicals

Draft - work in progress

Rudgea viburnoides (Cham.) Benth. // Rudgea viburnoides subsp. viburnoides

Family:: Rubiaceae
Approval state:: Approved
Number of articles retrieved:: 12
Number of processed references:: 2

Compositions

Endpoint Studies

Genotoxicity

Composition #1: Alves, R.M.S., Stehmann, J.R., Isaias, R.M.S., Brandão, M.G.L. Caracterização botânica e química de Rudgea viburnoides (Cham.) Benth., (Rubiaceae). Revista Brasileira de Farmacognosia, 2004, vol. 14, no. 1, p. 49–56. DOI: 10.1590/S0102-695X2004000100007. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Chloroform:acetic acid:methanol:water (60:32:12:8)
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Chromatographic tests (F015A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Saponins

Endpoint study #1: Monteiro, Juliana Castro., Pinto da Matta, Sergio Luis., Predes, Fabricia de Souza., de Oliveira, Tania Toledo. Liver Morphology and Morphometry and Plasma Biochemical Parameters of Wistar Rats that Received Leaf Infusion of Rudgea viburnoides Benth. (Rubiaceae). BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY, 2009, vol. 52, no. 2, p. 407–412. .

Study relevance:

Human health
Plant part:

Leaves (as part-nature) (A0EKT)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

water infusion of dried leaves, concentration in g dry leaves/L
Type of toxicological test:

short-term toxicity (CHD017TT)
Limit test:

Not applicable
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Wistar (CHD013ST)
Sex:

No data
Route of exposure:

ORAL: DRINKING WATER (OECD2229PL)
Exposure duration:

40.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

10
Control groups used:

yes
Endpoint measured:

Concentration level (CHD013EP)
Concentration unit:

Gram/litre (G016A)
Effect concentration:

20
Critical effect:

HEPATOTOXICITY (TOX02A)
Target tissue:

digestive: Liver (TT023A)
Effect description:

plasma TAG were decreased and this decrease was accompanied by microscopic fatty droplets in the liver
Effect or parameter linked to the endpoint:

histopathology non neoplastic (CHD025BE)
Internal remarks:

hepatotoxicity