Endpoint study
#1: Poon, W. T., Ho, C. H., Yip, K. L., Lai, C. K., Cheung, K. L., Sung, Rita Y. T., Chan, Albert Y. W., Mak, Tony W. L. Grayanotoxin poisoning from Rhododendron simsii in an infant. Hong Kong Medical Journal, 2008, vol. 14, no. 5, p. 405–407. .
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Study relevance:
Human health
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Substance:
Diterpenes Diterpenes (RF-00004378-PAR)
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Plant part:
Unspecified (A07XD)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
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Additional plant/substance description:
water (decoction)
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Type of toxicological test:
case report (CHD060TT)
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Tested organism:
Human (as organism) (A056J)
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Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
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Unit of exposure duration:
Minute (G074A)
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Number of organisms dosed:
1
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Endpoint measured:
Dose not reported (CHD066EP)
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Critical effect:
NEUROTOXICITY (TOX04A)
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Target tissue:
neurologic: Central Nervous System (TT035A)
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Effect description:
A live plant decoction induced a severe poisoning in a 57 -day-old infant with vomiting,convulsions and shock
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Effect or parameter linked to the endpoint:
neurology (CHD027BE)
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Internal remarks:
A live plant decoction induced a severe poisoning in a 57 -day-old infant with vomiting,convulsions and shock
Endpoint study
#2: Vargas Junior, Sergio Farias., Marcolongo-Pereira, Clairton., Halinski-Silveira, Denis., Grecco, Fabiane Borelli., Raffi, Margarida Buss., Schild, Ana Lucia., Viegas Sallis, Eliza Simone. Rhododendron simsii poisoning in goats in Southern Brazil. CIENCIA RURAL, 2014, vol. 44, no. 7, p. 1249–1252. DOI: 10.1590/0103-8478cr20131331.
[
DOI link]
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Study relevance:
Animal (target species) health
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Plant part:
Aerial part of plants (as part-nature) (A166F)
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Type of toxicological test:
case report (CHD060TT)
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Tested organism:
Goat (as animal) (A057P)
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Route of exposure:
ORAL: FEED (OECD2230PL)
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Unit of exposure duration:
Hour (G099A)
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Number of organisms dosed:
8
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Endpoint measured:
Dose not reported (CHD066EP)
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Critical effect:
Other toxicities (TOX19A)
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Target tissue:
cardiovascular / haematological: Heart (TT011A)
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Effect description:
restlessness, shrill bleating, profuse regurgitation, colic, looking and kicking at the flank, a loss of balance, irregular gait, staggering, and opisthotonos
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Effect or parameter linked to the endpoint:
mortality (CHD010BE)
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Internal remarks:
case report of toxicity in goats
Endpoint study
#3: Vargas Junior, Sergio Farias., Marcolongo-Pereira, Clairton., Halinski-Silveira, Denis., Grecco, Fabiane Borelli., Raffi, Margarida Buss., Schild, Ana Lucia., Viegas Sallis, Eliza Simone. Rhododendron simsii poisoning in goats in Southern Brazil. CIENCIA RURAL, 2014, vol. 44, no. 7, p. 1249–1252. DOI: 10.1590/0103-8478cr20131331.
[
DOI link]
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Study relevance:
Animal (target species) health
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Plant part:
Aerial part of plants (as part-nature) (A166F)
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Type of toxicological test:
short-term toxicity (CHD017TT)
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Tested organism:
Goat (as animal) (A057P)
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Route of exposure:
ORAL: FEED (OECD2230PL)
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Unit of exposure duration:
Meal (G109A)
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Number of organisms dosed:
2
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Endpoint measured:
Concentration level (CHD013EP)
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Concentration unit:
Gram/kilogram (G015A)
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Effect concentration:
21.5-30
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Critical effect:
Other toxicities (TOX19A)
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Target tissue:
cardiovascular / haematological: Heart (TT011A)
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Effect description:
Hypersalivation, restlessness, abdominal pain. Later, shrill bleating, incoordination, difficulty in standing; stemally recumbent. Unable to lift their head, opisthotonos, nystagmus, bruxism. The high-dose animal died after 33 hours
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Effect or parameter linked to the endpoint:
mortality (CHD010BE)
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Internal remarks:
short term toxicity in goats
