EFSA Compendium of Botanicals

Draft - work in progress

Rhododendron ferrugineum L.

Family:: Ericaceae
Approval state:: Approved
Number of articles retrieved:: 217
Number of processed references:: 2

Compositions

#1: Procyanidins B1 and B4 #2: Epigallocatechin #3: Scopoletin #4: Ferruginene A, B, C (sesquiterpenoid)

Endpoint Studies

Genotoxicity

Composition #1: Louis, A., Petereit, F., Canigueral, S., Hensel, A. Phytochemical characterisation of the leaves of Rhododendron ferrugineum L. . planta medica, 2009, vol. 75, no. 9, p. 1036–1036. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

acetone-water
Substance:

Proanthocyanidins (condensed tannins) Proanthocyanidins (condensed tannins) (RF-00004370-PAR)
Additional substance description:

procyanidins B1 and B4
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Procyanidins B1 and B4

Composition #2: Louis, A., Petereit, F., Canigueral, S., Hensel, A. Phytochemical characterisation of the leaves of Rhododendron ferrugineum L. . planta medica, 2009, vol. 75, no. 9, p. 1036–1036. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

acetone-water
Substance:

gallocatechin (RF-00003822-PAR)
Additional substance description:

epigallocatechin
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Epigallocatechin

Composition #3: Seephonkai, Prapairat., Popescu, Ruxandra., Zehl, Martin., Krupitza, Georg., Urban, Ernst., Kopp, Brigitte. Ferruginenes A-C from Rhododendron ferrugineum and Their Cytotoxic Evaluation . journal of natural products, 2011, vol. 74, no. 4, p. 712–717. DOI: 10.1021/np100778k. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH, solvent and column chromatography processing
Substance:

scopoletin (RF-00004048-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, IR, MS, UV
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Scopoletin

Composition #4: Seephonkai, Prapairat., Popescu, Ruxandra., Zehl, Martin., Krupitza, Georg., Urban, Ernst., Kopp, Brigitte. Ferruginenes A-C from Rhododendron ferrugineum and Their Cytotoxic Evaluation . journal of natural products, 2011, vol. 74, no. 4, p. 712–717. DOI: 10.1021/np100778k. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH, solvent and column chromatography processing
Substance:

Benzofurans (RF-00010791-PAR)
Additional substance description:

Ferruginene A, B, C
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, IR, MS, UV
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Ferruginene A, B, C (sesquiterpenoid)