EFSA Compendium of Botanicals

Draft - work in progress

Quercus robur L.

Family:: Fagaceae
Approval state:: Approved
Number of articles retrieved:: 6037
Number of processed references:: 4

Compositions

#1: Gallic acid #2: Aesculetin #3: Scopoletin #4: Sinapaldehyde #5: gallic acid and derivatives #6: Gallotannins #7: Dimeric proanthocyanidins: (+)-catechin-(4alpha-8)-(+)-catechin, 3-O-galloyl-(+)-catechin-(4alpha-8)-3-O-galloyl-(+)-catechin, 3-O-galloyl-(+)-gallocatechin-(4beta-8)-(+)-gallocatechin, (-)- epicatechin-(4beta-8)-3-O-galloyl-(-)-epigallocatechin gallate, 3-O-galloyl-(-)-epicatecln'n-(4beta-8)-3-O-galloyl-(-)-epigallocatechin, 3-O-galloyl-(-)-epigallocatechin-(4beta-8)- (+)-catechin; #8: Oligomeric proanthocyanidins: D14-D19. #9: Grandinin/roburin E Ellagitannins #10: Vescalagin/castalagin - Ellagitannins #11: Gallic acid

Endpoint Studies

Genotoxicity

Composition #1: Fernandez De Simon, Brigida., Cadahia, Estrella., Conde, Elvira., Garcia-Vallejo, Maria Concepcion. Low molecular weight phenolic compounds in Spanish oak woods. journal of agricultural and food chemistry, 1996, vol. 44, no. 6, p. 1507–1511. DOI: 10.1021/jf9502461. [DOI link]

Language:

English (en)
Plant part:

Trunk (as part-nature) (A166N)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH/water 1:1
Substance:

gallic acid (RF-00003821-PAR)
Analytical method code:

HPLC-DAD (F587A)
Result unit:

Microgram/gram (G049A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

100
Internal remarks:

Gallic acid

Composition #2: Fernandez De Simon, Brigida., Cadahia, Estrella., Conde, Elvira., Garcia-Vallejo, Maria Concepcion. Low molecular weight phenolic compounds in Spanish oak woods. journal of agricultural and food chemistry, 1996, vol. 44, no. 6, p. 1507–1511. DOI: 10.1021/jf9502461. [DOI link]

Language:

English (en)
Plant part:

Trunk (as part-nature) (A166N)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH/water 1:1
Substance:

Esculetin (RF-00003667-PAR)
Additional substance description:

aesculetin
Analytical method code:

HPLC-DAD (F587A)
Result unit:

Microgram/gram (G049A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.83
Internal remarks:

Aesculetin

Composition #3: Fernandez De Simon, Brigida., Cadahia, Estrella., Conde, Elvira., Garcia-Vallejo, Maria Concepcion. Low molecular weight phenolic compounds in Spanish oak woods. journal of agricultural and food chemistry, 1996, vol. 44, no. 6, p. 1507–1511. DOI: 10.1021/jf9502461. [DOI link]

Language:

English (en)
Plant part:

Trunk (as part-nature) (A166N)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH/water 1:1
Substance:

scopoletin (RF-00004048-PAR)
Analytical method code:

HPLC-DAD (F587A)
Result unit:

Microgram/gram (G049A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.27
Internal remarks:

Scopoletin

Composition #4: Fernandez De Simon, Brigida., Cadahia, Estrella., Conde, Elvira., Garcia-Vallejo, Maria Concepcion. Low molecular weight phenolic compounds in Spanish oak woods. journal of agricultural and food chemistry, 1996, vol. 44, no. 6, p. 1507–1511. DOI: 10.1021/jf9502461. [DOI link]

Language:

English (en)
Plant part:

Trunk (as part-nature) (A166N)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH/water 1:1
Substance:

4-Hydroxy-3,5-dimethoxycinnamaldehyde (RF-00010194-PAR)
Analytical method code:

HPLC-DAD (F587A)
Result unit:

Microgram/gram (G049A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.94
Internal remarks:

Sinapaldehyde

Composition #5: Farag, Salwa F., El-Emary, Nasr A., Niwa, Masatake. Gallotannins from Quercus robur cultivated in Egypt. bulletin of pharmaceutical sciences, assiut university, 1998, p. 1–6. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Unspecified
Substance:

gallic acid (RF-00003821-PAR)
Additional substance description:

gallic acid and derivatives
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

spectroscopic techniques
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

gallic acid and derivatives

Composition #6: Farag, Salwa F., El-Emary, Nasr A., Niwa, Masatake. Gallotannins from Quercus robur cultivated in Egypt. bulletin of pharmaceutical sciences, assiut university, 1998, p. 1–6. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Unspecified
Substance:

Gallotannins (RF-00013316-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

spectroscopic techniques
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Gallotannins

Composition #7: Kuliev, Z.A., Vdovin, A.D., Abdullaev, N.D., Makhmatkulov, A.B., Malikov, V.M. Study of the catechins and proanthocyanidins of Quercus robur. chemistry of natural compounds, 1997, vol. 33, no. 6, p. 642–652. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Water-Ethanol
Substance:

Proanthocyanidins (condensed tannins) Proanthocyanidins (condensed tannins) (RF-00004370-PAR)
Additional substance description:

Dimeric proanthocyanidins
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, UV, IR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Dimeric proanthocyanidins: (+)-catechin-(4alpha-8)-(+)-catechin, 3-O-galloyl-(+)-catechin-(4alpha-8)-3-O-galloyl-(+)-catechin, 3-O-galloyl-(+)-gallocatechin-(4beta-8)-(+)-gallocatechin, (-)- epicatechin-(4beta-8)-3-O-galloyl-(-)-epigallocatechin gallate, 3-O-galloyl-(-)-epicatecln'n-(4beta-8)-3-O-galloyl-(-)-epigallocatechin, 3-O-galloyl-(-)-epigallocatechin-(4beta-8)- (+)-catechin;

Composition #8: Kuliev, Z.A., Vdovin, A.D., Abdullaev, N.D., Makhmatkulov, A.B., Malikov, V.M. Study of the catechins and proanthocyanidins of Quercus robur. chemistry of natural compounds, 1997, vol. 33, no. 6, p. 642–652. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Water-Ethanol
Substance:

Proanthocyanidins (condensed tannins) Proanthocyanidins (condensed tannins) (RF-00004370-PAR)
Additional substance description:

Oligomeric proanthocyanidins: D14-D19.
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, UV, IR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Oligomeric proanthocyanidins: D14-D19.

Composition #9: Mammela, P., Savolainen, H., Lindroos, L., Kangas, J., Vartiainen, T. Analysis of oak tannins by liquid chromatography-electrospray ionisation mass spectrometry . journal of chromatography a, 2000, vol. 891, no. 1, p. 75–83. DOI: 10.1016/S0021-9673(00)00624-5. [DOI link]

Language:

English (en)
Plant part:

Trunk (as part-nature) (A166N)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH - water
Substance:

Ellagitannins (hydrolysable tannins) Ellagitannins (hydrolysable tannins) (RF-00004379-PAR)
Additional substance description:

Grandinin/roburin E
Analytical method code:

HPLC with standard detection methods (F019A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Grandinin/roburin E Ellagitannins

Composition #10: Mammela, P., Savolainen, H., Lindroos, L., Kangas, J., Vartiainen, T. Analysis of oak tannins by liquid chromatography-electrospray ionisation mass spectrometry . journal of chromatography a, 2000, vol. 891, no. 1, p. 75–83. DOI: 10.1016/S0021-9673(00)00624-5. [DOI link]

Language:

English (en)
Plant part:

Trunk (as part-nature) (A166N)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH - water
Substance:

Ellagitannins (hydrolysable tannins) Ellagitannins (hydrolysable tannins) (RF-00004379-PAR)
Additional substance description:

Vescalagin/castalagin
Analytical method code:

HPLC with standard detection methods (F019A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Vescalagin/castalagin - Ellagitannins

Composition #11: Mammela, P., Savolainen, H., Lindroos, L., Kangas, J., Vartiainen, T. Analysis of oak tannins by liquid chromatography-electrospray ionisation mass spectrometry . journal of chromatography a, 2000, vol. 891, no. 1, p. 75–83. DOI: 10.1016/S0021-9673(00)00624-5. [DOI link]

Language:

English (en)
Plant part:

Trunk (as part-nature) (A166N)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH - water
Substance:

gallic acid (RF-00003821-PAR)
Analytical method code:

HPLC with standard detection methods (F019A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Gallic acid