Composition #1: Barbetti, P., Grandolini, G., Fardella, G., Chiappini, I. Indole Alkaloids from Quassia amara.. Planta medica, 1987, vol. 53, no. 3, p. 289–90. DOI: 10.1055/s-2006-962709.
[
DOI link]
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Plant part:
Wood (as part-nature) (A166P)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
CHCI3-soluble alkaline extract
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Substance:
carboline alkaloids (RF-00004384-PAR)
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Additional substance description:
1-vinyl-4,8-dimethoxy--carboline, 1-methoxycarbonyl-3-carboline, and 3-methylcantin-2,6-dione
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Analytical method code:
Chromatography hyphenated to element spectrometry (F355A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
beta-carboline alkaloids
Composition #2: NJAR, VCO., ALAO, TO., OKOGUN, JI., HOLLAND, HL. 2-METHOXYCANTHIN-6-ONE - A NEW ALKALOID FROM THE STEM WOOD OF QUASSIA-AMARA. PLANTA MEDICA, 1993, vol. 59, no. 3, p. 259–261. DOI: 10.1055/s-2006-959664.
[
DOI link]
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Plant part:
Wood (as part-nature) (A166P)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
methanol
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Substance:
Alkaloids (RF-00004360-PAR)
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Additional substance description:
2-Methoxycanthin-6-one
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
2-Methoxycanthin-6-one
Endpoint study
#1: Raji, Yinusa., Akinola, Adeniran., Oyeyipo, Ibukun P., Femi-Akinlosotu, Omowunmi. Reproductive activities of female albino rats treated with quassin, a bioactive triterpenoid from stem bark extract of Quassia amara.. Physiological Society of Nigeria, 2010, vol. 25, no. 2, p. 95–102. .
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Study relevance:
Human health
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Substance:
Quassin (RF-0884-001-PPP)
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Plant part:
Bark (as part-nature) (A066X)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
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Additional plant/substance description:
methanol
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Type of toxicological test:
reproduction toxicity (CHD009TT)
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Tested organism:
Rat (as animal) (A0CNV)
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Route of exposure:
ORAL: FEED (OECD2230PL)
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Unit of exposure duration:
Day (G134A)
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Number of organisms dosed:
5
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Endpoint measured:
Concentration level (CHD013EP)
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Concentration unit:
Milligram/kilogram (G061A)
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Effect concentration:
0.1-2
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Critical effect:
REPRODUCTIVE (TOX05A)
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Target tissue:
urogenital: Ovaries (TT047A)
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Effect description:
Significant decrease in the mean weight of ovary and in serum estrogen levels of rats treated with quassin; decreased mean litter number and weight
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Effect or parameter linked to the endpoint:
reproduction (CHD014BE)
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Internal remarks:
quassin has female anti-fertility properties
Endpoint study
#2: Raji, Y., Bolarinwa, AF. Antifertility activity of Quassia amara in male rats - In vivo study. LIFE SCIENCES, 1997, vol. 61, no. 11, p. 1067–1074. DOI: 10.1016/S0024-3205(97)00615-2.
[
DOI link]
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Study relevance:
Human health
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Substance:
Quassin (RF-0884-001-PPP)
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Plant part:
Wood (as part-nature) (A166P)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
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Additional plant/substance description:
methanol extract of stem wood
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Type of toxicological test:
reproduction toxicity (CHD009TT)
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Tested organism:
Rat (as animal) (A0CNV)
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Strain of test organism:
Wistar (CHD013ST)
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Route of exposure:
ORAL: FEED (OECD2230PL)
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Number of organisms dosed:
5
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-
Endpoint measured:
Concentration level (CHD013EP)
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Concentration unit:
Milligram/kilogram (G061A)
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Effect concentration:
0.1-2
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Critical effect:
REPRODUCTIVE (TOX05A)
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Target tissue:
urogenital: Testes (TT050A)
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Effect description:
mean weights of testes, seminal vesicles and epididymides significantly reduced; reduction of levels of levels of LH, FSH and testosterone; reduction in sperm count
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Effect or parameter linked to the endpoint:
reproduction (CHD014BE)
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Internal remarks:
quassin associated with antisteroidogenic and antifertility actions.
