EFSA Compendium of Botanicals

Draft - work in progress

Prunus mahaleb L.

Family:: Rosaceae
Approval state:: Approved
Number of articles retrieved:: 534
Number of processed references:: 4

Compositions

#1: Coumarin #2: Coumarin #3: Herniarin in leaves and bark

Endpoint Studies

Genotoxicity

#1: Mutagenic activities at the studied concentrations (0.78–25 mg/mL)

Composition #1: Ieri, Francesca., Pinelli, Patrizia., Romani, Annalisa. Simultaneous determination of anthocyanins, coumarins and phenolic acids in fruits, kernels and liqueur of Prunus mahaleb L . food chemistry, 2012, vol. 135, no. 4, p. 2157–2162. DOI: 10.1016/j.foodchem.2012.07.083. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH (70%)
Substance:

Coumarin (RF-00000370-TOX)
Analytical method code:

HPLC-DAD (F587A)
Result unit:

Gram/litre (G016A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.740
Internal remarks:

Coumarin

Composition #2: Ozturk, Ismet., Karaman, Safa., Baslar, Mehmet., Cam, Mustafa., Caliskan, Oznur., Sagdic, Osman., Yalcin, Hasan. Aroma, Sugar and Anthocyanin Profile of Fruit and Seed of Mahlab (Prunus mahaleb L.): Optimization of Bioactive Compounds Extraction by Simplex Lattice Mixture Design. FOOD ANALYTICAL METHODS, 2014, vol. 7, no. 4, p. 761–773. DOI: 10.1007/s12161-013-9679-4. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Coumarin (RF-00000370-TOX)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.11
Internal remarks:

Coumarin

Composition #3: SANTAMOUR, FS., RIEDEL, LGH. DISTRIBUTION AND INHERITANCE OF SCOPOLIN AND HERNIARIN IN SOME PRUNUS SPECIES . biochemical systematics and ecology, 1994, vol. 22, no. 2, p. 197–201. DOI: 10.1016/0305-1978(94)90008-6. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH
Substance:

herniarin (RF-00010991-PAR)
Additional substance description:

in leaves and bark
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Herniarin in leaves and bark

Genotox #1: Abudayyak, Mahmoud., Ozdemir Nath, Ebru., Ozhan, Gul. Toxic potentials of ten herbs commonly used for aphrodisiac effect in Turkey. TURKISH JOURNAL OF MEDICAL SCIENCES, 2015, vol. 45, no. 3, p. 496–506. DOI: 10.3906/sag-1401-153. [DOI link]

Study category:

Mutagenicity
Type of toxicological test:

in vitro mammalian cell micronucleus test (CHD033TT)
Method type:

in vitro
Tested organism:

Salmonella typhimurium (as organism) (A0CPZ)
Exogenous metabolic activation applied:

with and without
Control groups used:

yes
Endpoint measured:

gene mutation
Is genotoxic:

Positive
Remarks on genotox study:

Mutagenic activities at the studied concentrations (0.78–25 mg/mL)
Internal remarks:

Mutagenic activities at the studied concentrations (0.78–25 mg/mL)
Internal ID:

WOS:000356357800005