EFSA Compendium of Botanicals

Draft - work in progress

Protium heptaphyllum (Aubl.) Marchand

Family:: Burseraceae
Approval state:: Approved
Number of articles retrieved:: 182
Number of processed references:: 7

Compositions

#1: Myrcene #2: Monoterpene ketones #3: Trans ascaridole #4: 1,8 cineole #5: Camphor #6: Methyl eugenol #7: Dillapiole #8: Myrcene in essential oil from the stems #9: Dillapiole in essential oil from the stems #10: Myrcene in essential oil from the leaves #11: Coumarins (fraxetin, scopoletin) #12: Coumarolignanoids (cleomiscosin A, Propacin) #13: Myrcene #14: Myristicin #15: Apiole

Endpoint Studies

Genotoxicity

Composition #1: Teles Pontes, Wendel Jose., Guerra de Oliveira, Jose Candido., Gomes da Camara, Claudio Augusto., Lopes, Adelmo C. H. R., Gorreia Gondim, Manoel Guedes., de Oliveira, Jose Vargas., Barros, Reginaldo., Erwin Schwartz, Manfred Oswald. Chemical composition and acaricidal activity of the leaf and fruit essential oils of Protium heptaphyllum (Aubl.) Marchand (Burseraceae) . acta amazonica, 2007, vol. 37, no. 1, p. 103–109. DOI: 10.1590/S0044-59672007000100012. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2
Internal remarks:

Myrcene

Composition #2: Teles Pontes, Wendel Jose., Guerra de Oliveira, Jose Candido., Gomes da Camara, Claudio Augusto., Lopes, Adelmo C. H. R., Gorreia Gondim, Manoel Guedes., de Oliveira, Jose Vargas., Barros, Reginaldo., Erwin Schwartz, Manfred Oswald. Chemical composition and acaricidal activity of the leaf and fruit essential oils of Protium heptaphyllum (Aubl.) Marchand (Burseraceae) . acta amazonica, 2007, vol. 37, no. 1, p. 103–109. DOI: 10.1590/S0044-59672007000100012. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

monoterpene ketones (RF-00010825-PAR)
Additional substance description:

karahanaenone, verbenone
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.1- 1.6
Internal remarks:

Monoterpene ketones

Composition #3: Teles Pontes, Wendel Jose., Guerra de Oliveira, Jose Candido., Gomes da Camara, Claudio Augusto., Lopes, Adelmo C. H. R., Gorreia Gondim, Manoel Guedes., de Oliveira, Jose Vargas., Barros, Reginaldo., Erwin Schwartz, Manfred Oswald. Chemical composition and acaricidal activity of the leaf and fruit essential oils of Protium heptaphyllum (Aubl.) Marchand (Burseraceae) . acta amazonica, 2007, vol. 37, no. 1, p. 103–109. DOI: 10.1590/S0044-59672007000100012. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

ascaridol (RF-00004159-PAR)
Additional substance description:

trans ascaridol
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.2
Internal remarks:

Trans ascaridole

Composition #4: Siani, A.C., Ramos, M.F.S., Guimarães, A.C., Susunaga, G.S., Zoghbi, M.D.G.B. Volatile constituents from oleoresin of Protium heptaphyllum (Aubl.) march. journal of essential oil research, 1999, vol. 11, no. 1, p. 72–74. .

Language:

English (en)
Plant part:

Trunk (as part-nature) (A166N)
Extraction/Preparation method:

Resin (as part-nature) (A166X)
Additional extraction description:

hydrodistillation
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.1- 1.4
Internal remarks:

1,8 cineole

Composition #5: Siani, A.C., Ramos, M.F.S., Guimarães, A.C., Susunaga, G.S., Zoghbi, M.D.G.B. Volatile constituents from oleoresin of Protium heptaphyllum (Aubl.) march. journal of essential oil research, 1999, vol. 11, no. 1, p. 72–74. .

Language:

English (en)
Plant part:

Trunk (as part-nature) (A166N)
Extraction/Preparation method:

Resin (as part-nature) (A166X)
Additional extraction description:

hydrodistillation
Substance:

Camphor (RF-00003986-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.2
Internal remarks:

Camphor

Composition #6: Siani, A.C., Ramos, M.F.S., Guimarães, A.C., Susunaga, G.S., Zoghbi, M.D.G.B. Volatile constituents from oleoresin of Protium heptaphyllum (Aubl.) march. journal of essential oil research, 1999, vol. 11, no. 1, p. 72–74. .

Language:

English (en)
Plant part:

Trunk (as part-nature) (A166N)
Extraction/Preparation method:

Resin (as part-nature) (A166X)
Additional extraction description:

hydrodistillation
Substance:

methyleugenol (RF-00003931-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.2- 3.8
Internal remarks:

Methyl eugenol

Composition #7: Siani, A.C., Ramos, M.F.S., Guimarães, A.C., Susunaga, G.S., Zoghbi, M.D.G.B. Volatile constituents from oleoresin of Protium heptaphyllum (Aubl.) march. journal of essential oil research, 1999, vol. 11, no. 1, p. 72–74. .

Language:

English (en)
Plant part:

Trunk (as part-nature) (A166N)
Extraction/Preparation method:

Resin (as part-nature) (A166X)
Additional extraction description:

hydrodistillation
Substance:

Dillapiole (RF-00004277-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0-16
Internal remarks:

Dillapiole

Composition #8: Zoghbi, Maria das G.B., Maia, Jose G.S., Luz, Arnaldo I.R. Volatile constituents from leaves and stems of Protium heptaphyllum (Aubl.) March.. journal of essential oil research, 1995, vol. 7, no. 5, p. 541–543. .

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

steam distillation
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.9
Internal remarks:

Myrcene in essential oil from the stems

Composition #9: Zoghbi, Maria das G.B., Maia, Jose G.S., Luz, Arnaldo I.R. Volatile constituents from leaves and stems of Protium heptaphyllum (Aubl.) March.. journal of essential oil research, 1995, vol. 7, no. 5, p. 541–543. .

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

steam distillation
Substance:

Dillapiole (RF-00004277-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.31
Internal remarks:

Dillapiole in essential oil from the stems

Composition #10: Bandeira, PN., Machado, MIL., Cavalcanti, FS., Lemos, TLG. Essential oil composition of leaves, fruits and resin of Protium heptaphyllum (Aubl.) March. . journal of essential oil research, 2001, vol. 13, no. 1, p. 33–34. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

18.6
Internal remarks:

Myrcene in essential oil from the leaves

Composition #11: Almeida, EX., Conserva, LM., Lemos, RPL. Coumarins, coumarinolignoids and terpenes from Protium heptaphyllum. BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2002, vol. 30, no. 7, p. 685–687. DOI: 10.1016/S0305-1978(01)00130-2. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH (90%)
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

fraxetin, scopoletin
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Coumarins (fraxetin, scopoletin)

Composition #12: Almeida, EX., Conserva, LM., Lemos, RPL. Coumarins, coumarinolignoids and terpenes from Protium heptaphyllum. BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2002, vol. 30, no. 7, p. 685–687. DOI: 10.1016/S0305-1978(01)00130-2. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH (90%)
Substance:

Coumarinolignoids (RF-00010800-PAR)
Additional substance description:

cleomiscosin A, Propacin
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Coumarolignanoids (cleomiscosin A, Propacin)

Composition #13: Siani, Antonio C., Ramos, Monica Freiman S., Monteiro, Sergio da S., Ribeiro-dos-Santos, Ricardo., Soares, Renata Oliveira A. Essential oils of the Oleoresins from Protium Heptaphyllum Growing in the Brazilian Southeastern and their Cytotoxicity to Neoplasic Cells Lines . journal of essential oil bearing plants, 2011, vol. 14, no. 3, p. 373–378. DOI: 10.1080/0972060X.2011.10643948. [DOI link]

Language:

English (en)
Plant part:

Trunk (as part-nature) (A166N)
Extraction/Preparation method:

Resin (as part-nature) (A166X)
Additional extraction description:

hydrodistillation
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

35
Internal remarks:

Myrcene

Composition #14: Silva, Jefferson Rocha de A., Zoghbi, Maria das G. B., Pinto, Angelo da C., Godoy, Ronoel L. O., Amaral, Ana Claudia F. Analysis of the Hexane Extracts From Seven Oleoresins of Protium Species. JOURNAL OF ESSENTIAL OIL RESEARCH, 2009, vol. 21, no. 4, p. 305–308. .

Language:

English (en)
Plant part:

Trunk (as part-nature) (A166N)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Hexane
Substance:

myristicin (RF-00003941-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.4
Internal remarks:

Myristicin

Composition #15: Silva, Jefferson Rocha de A., Zoghbi, Maria das G. B., Pinto, Angelo da C., Godoy, Ronoel L. O., Amaral, Ana Claudia F. Analysis of the Hexane Extracts From Seven Oleoresins of Protium Species. JOURNAL OF ESSENTIAL OIL RESEARCH, 2009, vol. 21, no. 4, p. 305–308. .

Language:

English (en)
Plant part:

Trunk (as part-nature) (A166N)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Hexane
Substance:

apiole (RF-00003690-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

9.6
Internal remarks:

Apiole