EFSA Compendium of Botanicals

Endpoint study #1: Pinto, Marcia Da Silva., Ranilla, Lena Galvez., Apostolidis, Emmanouil., Lajolo, Franco Maria., Genovese, Maria Ines., Shetty, Kalidas. Evaluation of antihyperglycemia and antihypertension potential of native Peruvian fruits using in vitro models.. Journal of medicinal food, 2009, vol. 12, no. 2, p. 278–91. DOI: 10.1089/jmf.2008.0113. [DOI link]

Study relevance:

Human health
Plant part:

Fruit unspecified (as part-nature) (A067D)
Preparation/Extraction method:

Drying (dehydration) (A07KG)
Additional plant/substance description:

ethanol extract of ground dried fruit
Type of toxicological test:

in vitro (CHD061TT)
Route of exposure:

OTHER (OECD0PL)
Exposure duration:

10.0
Unit of exposure duration:

Minute (G074A)
Control groups used:

no data
Endpoint measured:

Enzyme inhibition (CHD067EP)
Concentration unit:

Percent (G138A)
Effect concentration:

48-64
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

Amylase and alpha-glucosidase (maltase) inhibition
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

Inhibition of digestive enzymes (alpha-amylase, alpha-glucosidase)

Pouteria lucuma (Ruiz & Pav.) Kuntze // Lucuma obovata Kunth