EFSA Compendium of Botanicals

Draft - work in progress

Polyscias fruticosa (L.) Harms

Family:: Araliaceae
Approval state:: Approved
Number of articles retrieved:: 45
Number of processed references:: 5

Compositions

#1: Saponins in root #2: heptadeca-1,8(E)-diene-4,6-diyne3,10-diol ( polyacetylene derivative) in roots #3: Triterpenoid saponins in leaves and roots #4: Eight new oleanane saponins (polysciosides A-H) and three known saponins from leaves and roots

Endpoint Studies

#1: alpha-glucosidase inhibition by the polyphenol content from water extract #2: alpha-glucosidase inhibition by the polyphenol content from methanol extract

Genotoxicity

Composition #1: Vo Xuan Minh., Pham Huu Duong., Le Thanh Ha. Study of chemical composition and dosage form of Polyscias fruticosa Harm. tap chi duoc hoc, 1991, p. 19–21. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Unspecified (F598A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.49
Internal remarks:

Saponins in root

Composition #2: Lutomski, J., Luan, T. C. Polyacetylenes in the Araliaceae family. Part III. The qualitative and quantitative determination of the polyacetylenes from the crude extracts of Panax vietnamensis Ha et Grushv. and Polyscias fruticosa (L.) Harms. by thin layer chromatography and spectrophotometry. herba polonica, 1992, p. 53–61. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

petroleum ether and ethanol (1:1)
Substance:

polyacetylene derivatives polyacetylene derivatives (RF-00004332-PAR)
Additional substance description:

heptadeca-1,8(E)-diene-4,6-diyne310-diol,
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.003
Internal remarks:

heptadeca-1,8(E)-diene-4,6-diyne3,10-diol ( polyacetylene derivative) in roots

Composition #3: Bernard, B M., Pakianathan, N., Venkataswamy, R., Divakar, M C. A pharmacognostic report on the leaf and root of polyscias fruticosa (L.) harms. . ancient science of life, 1998, vol. 18, no. 2, p. 165–72. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

n-butanoltriterpeboid saponins
Substance:

Saponins (RF-00004333-PAR)
Additional substance description:

triterpenoid saponins
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Triterpenoid saponins in leaves and roots

Composition #4: Huan, VD., Yamamura, S., Ohtani, K., Kasai, R., Yamasaki, K., Nham, NT., Chau, HM. Oleanane saponins from Polyscias fruticosa. PHYTOCHEMISTRY, 1998, vol. 47, no. 3, p. 451–457. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

Saponins (RF-00004333-PAR)
Additional substance description:

Eight oleanane saponins (polysciosides A-H) and three known saponins from leaves and roots
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Eight new oleanane saponins (polysciosides A-H) and three known saponins from leaves and roots

Endpoint study #1: Mai, Truong Tuyet., Thu, Nghiem Nguyet., Tien, Pham Gia., Van Chuyen, Nguyen. Alpha-glucosidase inhibitory and antioxidant activities of Vietnamese edible plants and their relationships with polyphenol contents . journal of nutritional science and vitaminology, 2007, vol. 53, no. 3, p. 267–276. DOI: 10.3177/jnsv.53.267. [DOI link]

Study relevance:

Human health
Plant part:

Unspecified (A07XD)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

polyphenol content; water extract
Type of toxicological test:

in vitro (CHD061TT)
Endpoint measured:

Half maximal inhibitory concentration (CHD021EP)
Concentration unit:

Millimole (G115A)
Effect concentration:

0.00049
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

alpha-glucosidase inhibition; expressed as mmol catechin equivalent
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

alpha-glucosidase inhibition by the polyphenol content from water extract

Endpoint study #2: Mai, Truong Tuyet., Thu, Nghiem Nguyet., Tien, Pham Gia., Van Chuyen, Nguyen. Alpha-glucosidase inhibitory and antioxidant activities of Vietnamese edible plants and their relationships with polyphenol contents . journal of nutritional science and vitaminology, 2007, vol. 53, no. 3, p. 267–276. DOI: 10.3177/jnsv.53.267. [DOI link]

Study relevance:

Human health
Plant part:

Unspecified (A07XD)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

polyphenol content; methanol extract
Type of toxicological test:

in vitro (CHD061TT)
Endpoint measured:

Half maximal inhibitory concentration (CHD021EP)
Concentration unit:

Millimole (G115A)
Effect concentration:

0.00042
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

alpha-glucosidase inhibition; expressed as mmol catechin equivalent
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

alpha-glucosidase inhibition by the polyphenol content from methanol extract