EFSA Compendium of Botanicals

Draft - work in progress

Polygonatum sibiricum F.Delaroche

Family:: Asparagaceae
Approval state:: Approved
Number of articles retrieved:: 371
Number of processed references:: 8

Compositions

#1: Liriodendrin #2: Isoflavones #3: Syringaresinol #4: Anthraquinones #5: Total saponins in stems #6: Total saponins in roots #7: Polygonatines A and B #8: neosibiricoside A-D (steroidal saponins) in rhizome #9: polygonoides A and B (furostanol saponins) in rhizome #10: Polygonoides C to E #11: 2-Azetidine 2-carboxilyc acid in rhizome

Endpoint Studies

#1: Alpha-glucosidase inhibition by root water extract #2: Alpha-glucosidase inhibition by stem water extract #3: Alpha-glucosidase inhibition by polysaccharides from the roots #4: Alpha-glucosidase inhibition by polysaccharides from the stems

Genotoxicity

Composition #1: Sun, Longru., Li, Xian. Studies on chemical constituents of rhizome of Polygonatum sibiricum (II). zhongcaoyao, 2001, p. 586–588. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

Liriodendrin (RF-00011085-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR + ESI-MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Liriodendrin

Composition #2: Sun, Longru., Li, Xian. Studies on chemical constituents of rhizome of Polygonatum sibiricum (II). zhongcaoyao, 2001, p. 586–588. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

isoflavones (RF-00004359-PAR)
Additional substance description:

6,8-dimethyl-4',5,7-trihydroxyhomoisoflavone
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR + ESI-MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isoflavones

Composition #3: Sun, Longru., Li, Xian. Studies on chemical constituents of rhizome of Polygonatum sibiricum (II). zhongcaoyao, 2001, p. 586–588. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

syringaresinol (RF-00011386-PAR)
Additional substance description:

Syringaresinol and derivatives
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR + ESI-MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Syringaresinol

Composition #4: Dong, Li., Ni, Jing man. Preliminary study of an α-glucosidase inhibitor from the roots and stems of Polygonatum sibiricum Red. asian journal of traditional medicines, 2008, p. 179–185. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Water
Substance:

anthraquinones (RF-00004343-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Anthraquinones

Composition #5: Li, Ying., Zhao, Bing., Chen, Qian-liang., Ni, Shi-feng. Determination and comparison on the content of total saponins of Polygonatum sibiricun Red. and its callus. beifang yuanyi, 2011, p. 167–168. .

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

Saponins (RF-00004333-PAR)
Additional substance description:

Total saponins
Analytical method code:

Unspecified (F598A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.57
Internal remarks:

Total saponins in stems

Composition #6: Li, Ying., Zhao, Bing., Chen, Qian-liang., Ni, Shi-feng. Determination and comparison on the content of total saponins of Polygonatum sibiricun Red. and its callus. beifang yuanyi, 2011, p. 167–168. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

Saponins (RF-00004333-PAR)
Additional substance description:

Total saponins
Analytical method code:

Unspecified (F598A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.57
Internal remarks:

Total saponins in roots

Composition #7: Sun, LR., Li, X., Wang, SX. Two new alkaloids from the rhizome of Polygonatum sibiricum. journal of asian natural products research, 2005, vol. 7, no. 2, p. 127–130. DOI: 10.1080/10286020310001625157. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 90%
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

Polygonatines A and B
Analytical method code:

GC-MS (F046A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Polygonatines A and B

Composition #8: Ahn, MJ., Kim, CY., Yoon, KD., Ryu, MY., Cheong, JH., Chin, YW., Kim, J. Steroidal saponins from the rhizomes of Polygonatum sibiricum. JOURNAL OF NATURAL PRODUCTS, 2006, vol. 69, no. 3, p. 360–364. DOI: 10.1021/np050394d. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

steroidal saponins (RF-00010818-PAR)
Additional substance description:

neosibiricoside A-D
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

C and H NMR, HRFABMS, ESIMS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

neosibiricoside A-D (steroidal saponins) in rhizome

Composition #9: Xu, De-Ping., Hu, Chang-Ying., Zhang, Yang. Two new steroidal saponins from the rhizome of Polygonatum sibiricum. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2009, vol. 11, no. 1, p. 1–6. DOI: 10.1080/10286020802513681. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

steroidal furostan saponins steroidal furostan saponins (RF-00004397-PAR)
Additional substance description:

polygonoides A and B
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

HR-ESI-MS, NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

polygonoides A and B (furostanol saponins) in rhizome

Composition #10: Hu, Chang-Ying., Xu, De-Ping., Wu, Yu-Mei., Ou, Shi-Yi. Triterpenoid saponins from the rhizome of Polygonatum sibiricum. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2010, vol. 12, no. 9, p. 801–808. DOI: 10.1080/10286020.2010.505562. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Triterpene saponins Triterpene saponins (RF-00004338-PAR)
Additional substance description:

Polygonoides C to E
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

NMR, ESI-MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Polygonoides C to E

Composition #11: Baek, Seung-Hoon., Lee, Jin Gyun., Park, Seo Young., Piao, Xiang-Lan., Kim, Hyun Young., Bae, Ok-Nam., Park, Jeong Hill. Gas chromatographic determination of azetidine-2-carboxylic acid in rhizomes of Polygonatum sibiricum and Polygonatum odoratum . journal of food composition and analysis, 2012, vol. 25, no. 2, p. 137–141. DOI: 10.1016/j.jfca.2011.09.005. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water
Substance:

imidazole alkaloids (RF-00010804-PAR)
Additional substance description:

2-Azetidinecarboxylic acid
Analytical method code:

GC-MS (F046A)
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

5.39
Internal remarks:

2-Azetidine 2-carboxilyc acid in rhizome

Endpoint study #1: Dong, Li., Ni, Jing man. Preliminary study of an α-glucosidase inhibitor from the roots and stems of Polygonatum sibiricum Red. asian journal of traditional medicines, 2008, p. 179–185. .

Study relevance:

Human health
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

water extract
Type of toxicological test:

in vitro (CHD061TT)
Endpoint measured:

Enzyme inhibition (CHD067EP)
Concentration unit:

Percent (G138A)
Effect concentration:

67.08
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

Alpha-glucosidase inhibition
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

Alpha-glucosidase inhibition by root water extract

Endpoint study #2: Dong, Li., Ni, Jing man. Preliminary study of an α-glucosidase inhibitor from the roots and stems of Polygonatum sibiricum Red. asian journal of traditional medicines, 2008, p. 179–185. .

Study relevance:

Human health
Plant part:

Stem / stalk (as part-nature) (A067S)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

water extract
Type of toxicological test:

in vitro (CHD061TT)
Endpoint measured:

Enzyme inhibition (CHD067EP)
Concentration unit:

Percent (G138A)
Effect concentration:

67.08
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

Alpha-glucosidase inhibition
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

Alpha-glucosidase inhibition by stem water extract

Endpoint study #3: Dong, Li., Ni, Jing man. Preliminary study of an α-glucosidase inhibitor from the roots and stems of Polygonatum sibiricum Red. asian journal of traditional medicines, 2008, p. 179–185. .

Study relevance:

Human health
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Additional plant/substance description:

Polysaccharides
Type of toxicological test:

in vitro (CHD061TT)
Endpoint measured:

Enzyme inhibition (CHD067EP)
Concentration unit:

Percent (G138A)
Effect concentration:

80.19
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

Alpha-glucosidase inhibition
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

Alpha-glucosidase inhibition by polysaccharides from the roots

Endpoint study #4: Dong, Li., Ni, Jing man. Preliminary study of an α-glucosidase inhibitor from the roots and stems of Polygonatum sibiricum Red. asian journal of traditional medicines, 2008, p. 179–185. .

Study relevance:

Human health
Plant part:

Stem / stalk (as part-nature) (A067S)
Additional plant/substance description:

Polysaccharides
Type of toxicological test:

in vitro (CHD061TT)
Endpoint measured:

Enzyme inhibition (CHD067EP)
Concentration unit:

Percent (G138A)
Effect concentration:

80.19
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

Alpha-glucosidase inhibition
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

Alpha-glucosidase inhibition by polysaccharides from the stems