EFSA Compendium of Botanicals

Draft - work in progress

Polygonatum odoratum Druce // Polygonatum officinale All.

Family:: Liliaceae
Approval state:: Approved
Number of articles retrieved:: 742
Number of processed references:: 5

Compositions

#1: Mannose-binding lectin #2: Saponins #3: Azetidine-2-carboxylic acid in dry rhizome #4: Isoflavones in rhizome #5: Steroidal saponins in rhizomes. #6: Lignans in rhizome

Endpoint Studies

#1: Alpha-glucosidase inhibition by ethanol extract of the roots

Genotoxicity

Composition #1: Wu, Lei., Liu, Tao., Xiao, Yan., Li, Xin., Zhu, Yanan., Zhao, Yan., Bao, Jinku., Wu, Chuanfang. Polygonatum odoratum lectin induces apoptosis and autophagy by regulation of microRNA-1290 and microRNA-15a-3p in human lung adenocarcinoma A549 cells. international journal of biological macromolecules, 2016, p. 217–226. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

Lectins (RF-00000439-ORG)
Additional substance description:

mannose-binding lectin
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Mannose-binding lectin

Composition #2: Elekofehinti, O.O. Saponins: Anti-diabetic principles from medicinal plants - A review. Pathophysiology, 2015, vol. 22, no. 2, p. 95–103. DOI: 10.1016/j.pathophys.2015.02.001. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Additional extraction description:

unspecified
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Saponins

Composition #3: Baek, Seung-Hoon., Lee, Jin Gyun., Park, Seo Young., Piao, Xiang-Lan., Kim, Hyun Young., Bae, Ok-Nam., Park, Jeong Hill. Gas chromatographic determination of azetidine-2-carboxylic acid in rhizomes of Polygonatum sibiricum and Polygonatum odoratum. JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 2012, vol. 25, no. 2, p. 137–141. DOI: 10.1016/j.jfca.2011.09.005. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol–water mixture (1:1, v/v)
Substance:

imidazole alkaloids (RF-00010804-PAR)
Additional substance description:

2-Azetidinecarboxylic acid
Analytical method code:

GC-MS (F046A)
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

9.23
Internal remarks:

Azetidine-2-carboxylic acid in dry rhizome

Composition #4: Quan, Ling-Tong., Wang, Shao-Chen., Zhang, Jing. Chemical constituents from Polygonatum odoratum. BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2015, vol. 58, p. 281–284. DOI: 10.1016/j.bse.2014.12.019. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ETOH 95%
Substance:

isoflavones (RF-00004359-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR+MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isoflavones in rhizome

Composition #5: Quan, Ling-Tong., Wang, Shao-Chen., Zhang, Jing. Chemical constituents from Polygonatum odoratum. BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2015, vol. 58, p. 281–284. DOI: 10.1016/j.bse.2014.12.019. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH 95%
Substance:

steroidal saponins (RF-00010818-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR + MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Steroidal saponins in rhizomes.

Composition #6: Quan, Ling-Tong., Wang, Shao-Chen., Zhang, Jing. Chemical constituents from Polygonatum odoratum. BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2015, vol. 58, p. 281–284. DOI: 10.1016/j.bse.2014.12.019. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH 95%
Substance:

lignans (RF-00004361-PAR)
Additional substance description:

syringaresinol and derivatives, liriodendrin
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR + MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lignans in rhizome

Endpoint study #1: Zhou, Xiaoling., Liang, Junsheng., Zhang, Yi., Zhao, Huading., Guo, Ying., Shi, Shuyun. Separation and purification of alpha-glucosidase inhibitors from Polygonatum odoratum by stepwise high-speed counter-current chromatography combined with Sephadex LH-20 chromatography target-guided by ultrafiltration-HPLC screening. AND LIFE SCIENCES, 2015, vol. 985, p. 149–154. DOI: 10.1016/j.jchromb.2015.01.030. [DOI link]

Study relevance:

Human health
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

ethanol 75% extract
Type of toxicological test:

in vitro (CHD061TT)
Endpoint measured:

Half maximal inhibitory concentration (CHD021EP)
Concentration unit:

Milligram/millilitre (G191A)
Effect concentration:

2.59
Critical effect:

Digestive (TOX18A)
Target tissue:

digestive: Pancreas (TT024A)
Effect description:

Alpha-glucosidase inhibition
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

Alpha-glucosidase inhibition by ethanol extract of the roots