EFSA Compendium of Botanicals

Draft - work in progress

Polygala paniculata L.

Family:: Polygalaceae
Approval state:: Approved
Number of articles retrieved:: 47
Number of processed references:: 6

Compositions

#1: Methyl salicylate in the aerial part #2: Coumarin with epoxide group in the whole plant #3: coumarins in the whole plant #4: Murrangatin (coumarin) in live plant #5: Camphor in fruits #6: 1,8-cineole in fruits #7: Eugenol in fruits #8: Methyl salicylate in roots #9: 4- and 3-methoxy-methyl salicylate in root #10: 3’-O-acetyl-4’-O- benzoylkhellactone (pyranocoumarin) in whole plant

Endpoint Studies

Genotoxicity

Composition #1: da Rocha, Jose L. C., Pastore, Jose F. B., Brandao, Hugo N., Azeredo, Antonio., David, Juceni P., dos Santos, Edlene O., David, Jorge M. Quantification of methyl salicylate in four genera of the Polygalaceae by HPLC-DAD. quimica nova, 2012, p. 2263–2266. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

uspecified
Substance:

methyl salicylate (RF-00003930-PAR)
Analytical method code:

HPLC-DAD (F587A)
Result unit:

Microgram/gram (G049A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

24.00
Internal remarks:

Methyl salicylate in the aerial part

Composition #2: Klein Júnior, L.C., Faloni De Andrade, S., Filho, V.C. A pharmacognostic approach to the polygala genus: Phytochemical and pharmacological aspects. chemistry and biodiversity, 2012, vol. 9, no. 2, p. 181–209. DOI: 10.1002/cbdv.201000319. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CHCl2
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

8-(1'.2'-epoxy-3'-methylbut-3'-enyl)-7-metoxy coumarin (coumarin + epoxide group)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Coumarin with epoxide group in the whole plant

Composition #3: Hamburger, M., Gupta, M., Hostettmann, K. Coumarins from Polygala paniculata.. Planta medica, 1985, no. 3, p. 215–7. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

petrol ether, chloroform and methanol
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

Aurapten, phebalosin
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Analytical method - additional description:

Flash Chromathography and Centrifugal TLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

coumarins in the whole plant

Composition #4: Cristiano, R., Pizzolatti, MG., Delle Monache, F., Rezende, CM., Branco, A. Two xanthones from Polygala paniculata and confirmation of the 1-hydroxy-2,3,5-trimethoxy-xanthone at trace level by HRGC-MS. ZEITSCHRIFT FUR NATURFORSCHUNG C-A JOURNAL OF BIOSCIENCES, 2003, vol. 58, no. 7-8, p. 490–494. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Chloroform
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

Murrangatin
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

EIMS, IR, H and C NMR, NOE difference spectroscopy
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Murrangatin (coumarin) in live plant

Composition #5: Pizzolatti, Moacir G., Mendes, Beatriz G., Soldi, Cristian., Missau, Fabiana C., Bortoluzzi, Janaina H., Carasek, Eduardo. Analysis of Volatile Compounds Released From Flowers and Roots of Polygala cyparissias and Polygala paniculata by Headspace/SPME. JOURNAL OF ESSENTIAL OIL RESEARCH, 2009, vol. 21, no. 3, p. 255–258. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

HS/SPME extraction
Substance:

Camphor (RF-00003986-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.0
Internal remarks:

Camphor in fruits

Composition #6: Pizzolatti, Moacir G., Mendes, Beatriz G., Soldi, Cristian., Missau, Fabiana C., Bortoluzzi, Janaina H., Carasek, Eduardo. Analysis of Volatile Compounds Released From Flowers and Roots of Polygala cyparissias and Polygala paniculata by Headspace/SPME. JOURNAL OF ESSENTIAL OIL RESEARCH, 2009, vol. 21, no. 3, p. 255–258. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

HS/SPME extraction
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

13.0
Internal remarks:

1,8-cineole in fruits

Composition #7: Pizzolatti, Moacir G., Mendes, Beatriz G., Soldi, Cristian., Missau, Fabiana C., Bortoluzzi, Janaina H., Carasek, Eduardo. Analysis of Volatile Compounds Released From Flowers and Roots of Polygala cyparissias and Polygala paniculata by Headspace/SPME. JOURNAL OF ESSENTIAL OIL RESEARCH, 2009, vol. 21, no. 3, p. 255–258. .

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

HS/SPME extraction
Substance:

Eugenol (RF-00003807-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.3
Internal remarks:

Eugenol in fruits

Composition #8: Pizzolatti, Moacir G., Mendes, Beatriz G., Soldi, Cristian., Missau, Fabiana C., Bortoluzzi, Janaina H., Carasek, Eduardo. Analysis of Volatile Compounds Released From Flowers and Roots of Polygala cyparissias and Polygala paniculata by Headspace/SPME. JOURNAL OF ESSENTIAL OIL RESEARCH, 2009, vol. 21, no. 3, p. 255–258. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

HS/SPME extraction
Substance:

methyl salicylate (RF-00003930-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

89.1
Internal remarks:

Methyl salicylate in roots

Composition #9: Pizzolatti, Moacir G., Mendes, Beatriz G., Soldi, Cristian., Missau, Fabiana C., Bortoluzzi, Janaina H., Carasek, Eduardo. Analysis of Volatile Compounds Released From Flowers and Roots of Polygala cyparissias and Polygala paniculata by Headspace/SPME. JOURNAL OF ESSENTIAL OIL RESEARCH, 2009, vol. 21, no. 3, p. 255–258. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

HS/SPME extraction
Substance:

Salicylates (RF-00004331-PAR)
Additional substance description:

3- and 4-methoxy-methyl salicylate
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

6.7
Internal remarks:

4- and 3-methoxy-methyl salicylate in root

Composition #10: HAMBURGER, M., STOECKLIEVANS, H., HOSTETTMANN, K. A NEW PYRANOCOUMARIN DIESTER FROM POLYGALA-PANICULATA L. HELVETICA CHIMICA ACTA, 1984, vol. 67, no. 7, p. 1729–1733. DOI: 10.1002/hlca.19840670710. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Petroleum ether and methanol
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

3’-O-acetyl-4’-O- benzoylkhellactone
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

UV, IR, H-NMR, EI and CI MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

3’-O-acetyl-4’-O- benzoylkhellactone (pyranocoumarin) in whole plant