EFSA Compendium of Botanicals

Draft - work in progress

Plectranthus amboinicus (Lour.) Spreng.

Family:: Lamiaceae
Approval state:: Approved
Number of articles retrieved:: 227
Number of processed references:: 6

Compositions

#1: Alkaloids #2: Tannins #3: Catechol tannins #4: quinine #5: myrcene #6: Thymoquinone

Endpoint Studies

#1: Reported light to moderate adverse effects

Genotoxicity

Composition #1: Pillai, P.G., Suresh, P., Aggarwal, G., Doshi, G., Bhatia, V. Pharmacognostical standardization and toxicity profile of the methanolic leaf extract of Plectranthus amboinicus (Lour) Spreng. journal of applied pharmaceutical science, 2011, vol. 1, no. 2, p. 76–81. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids

Composition #2: Pillai, P.G., Suresh, P., Aggarwal, G., Doshi, G., Bhatia, V. Pharmacognostical standardization and toxicity profile of the methanolic leaf extract of Plectranthus amboinicus (Lour) Spreng. journal of applied pharmaceutical science, 2011, vol. 1, no. 2, p. 76–81. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tannins

Composition #3: El-Hawary, S.S., El-Sofany, R.H., Abdel-Monem, A.R., Ashour, R.S. Phytochemical screening, DNA fingerprinting, and nutritional value of Plectranthus amboinicus (Lour.) spreng. Pharmacognosy Journal, 2012, vol. 4, no. 30, p. 10–13. DOI: 10.5530/pj.2012.30.2. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Substance:

Tannins (RF-00004337-PAR)
Additional substance description:

Catechol tannins
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Catechol tannins

Composition #4: Patel, Roshan., Mahobia, Naveen K., Gendle, Ravindra., Kaushik, Basant., Singh, Sudarshan K. Diuretic activity of leaves of Plectranthus amboinicus (Lour) Spreng in male albino rats.. Pharmacognosy research, 2010, vol. 2, no. 2, p. 86–8. DOI: 10.4103/0974-8490.62956. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

petroleum ether, chloroform, ethanol and water
Substance:

quinine (RF-00004022-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

quinine

Composition #5: Verma, Ram S., Padalia, Rajendra C., Chauhan, Amit. Essential Oil Composition of Coleus aromaticus Benth. from Uttarakhand. journal of essential oil bearing plants, 2012, vol. 15, no. 2, p. 174–179. DOI: 10.1080/0972060X.2012.10644033. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.07
Internal remarks:

myrcene

Composition #6: Chen, Yuan-Siao., Yu, Hui-Ming., Shie, Jiun-Jie., Cheng, Ting-Jen Rachel., Wu, Chung-Yi., Fang, Jim-Min., Wong, Chi-Huey. Chemical constituents of Plectranthus amboinicus and the synthetic analogs possessing anti-inflammatory activity . bioorganic & medicinal chemistry, 2014, vol. 22, no. 5, p. 1766–1772. DOI: 10.1016/j.bmc.2014.01.009. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Hexane
Substance:

thymoquinone (RF-00004084-PAR)
Analytical method code:

Mass Spectroscopy and hyphenated methods without chromatography (F063A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Thymoquinone

Endpoint study #1: García Milián, A.J., Avila Pérez, Y., Alonso Carbonell, L., López Puig, P., Karelia Ruiz Salvador, A., Morón Rodríguez, F. Adverse reactions reported by consumption of natural products in Cuba during 2003 and 2007 Reacciones adversas reportadas por consumo de productos naturales en Cuba durante 2003 y 2007 . revista cubana de plantas medicinales, 2009, vol. 14, no. 1 . .

Study relevance:

Human health
Plant part:

Unspecified (A07XD)
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Human (as organism) (A056J)
Sex:

Female
Control groups used:

no data
Endpoint measured:

Dose not reported (CHD066EP)
Effect description:

Reported light to moderate adverse effects (no details)
Effect or parameter linked to the endpoint:

no data (CHD002BE)
Internal remarks:

Reported light to moderate adverse effects