Draft - work in progress
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- Piper retrofractum Vahl // Piper chaba Hunter
Piper retrofractum Vahl // Piper chaba Hunter
- Family:
- Piperaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 219
- Number of processed references:
- 7
Composition #1: Haribabu, Kothapalli., Ajitha, Makula., Mallavadhani, Uppuluri Venkata. Simultaneous determination of asaranin and sesamin in Piper chaba fruit by using HPTLC-MS method: effect of different extraction methods on the yield of marker compounds. Journal of Analytical Bioanalytical Techniques, 2014, p. 1000199/1–1000199/6. .
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Plant part:
Fruit unspecified (as part-nature) (A067D)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Methanol
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Substance:
lignans (RF-00004361-PAR)
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Additional substance description:
Sesamin
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Analytical method code:
Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
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Analytical method - additional description:
HPTLC-MS
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Sesamin
Composition #2: Haribabu, Kothapalli., Ajitha, Makula., Mallavadhani, Uppuluri Venkata. Simultaneous determination of asaranin and sesamin in Piper chaba fruit by using HPTLC-MS method: effect of different extraction methods on the yield of marker compounds. Journal of Analytical Bioanalytical Techniques, 2014, p. 1000199/1–1000199/6. .
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Plant part:
Fruit unspecified (as part-nature) (A067D)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Methanol
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Substance:
lignans (RF-00004361-PAR)
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Additional substance description:
asaranin
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Analytical method code:
Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
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Analytical method - additional description:
HPTLC-MS
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
asaranin
Composition #3: Bodiwala, Hardik S., Singh, Gaganmeet., Singh, Ranvir., Dey, Chinmoy Sankar., Sharma, Shyam Sundar., Bhutani, Kamlesh Kumar., Singh, Inder Pal. Antileishmanial amides and lignans from Piper cubeba and Piper retrofractum. JOURNAL OF NATURAL MEDICINES, 2007, vol. 61, no. 4, p. 418–421. DOI: 10.1007/s11418-007-0159-2.
[
DOI link]
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Plant part:
Stem / stalk (as part-nature) (A067S)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
n-hexane, ethyl acetate, and methanol
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Substance:
Piperidine alkaloids (RF-00004320-PAR)
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Additional substance description:
piplartine
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Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
piplartine
Composition #4: Bodiwala, Hardik S., Singh, Gaganmeet., Singh, Ranvir., Dey, Chinmoy Sankar., Sharma, Shyam Sundar., Bhutani, Kamlesh Kumar., Singh, Inder Pal. Antileishmanial amides and lignans from Piper cubeba and Piper retrofractum. JOURNAL OF NATURAL MEDICINES, 2007, vol. 61, no. 4, p. 418–421. DOI: 10.1007/s11418-007-0159-2.
[
DOI link]
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Plant part:
Stem / stalk (as part-nature) (A067S)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
n-hexane, ethyl acetate, and methanol
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Substance:
lignans (RF-00004361-PAR)
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Additional substance description:
(–)-sesamin
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Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
(–)-sesamin
Composition #5: Rao, V. Rama Subba., Suresh, G., Babu, K. Suresh., Raju, S. Satyanarayana., Vardhan, M. V. P. S. Vishnu., Ramakrishna, Sistla., Rao, J. Madhusudana. Novel dimeric amide alkaloids from Piper chaba Hunter: isolation, cytotoxic activity, and their biomimetic synthesis . tetrahedron, 2011, vol. 67, no. 10, p. 1885–1892. DOI: 10.1016/j.tet.2011.01.015.
[
DOI link]
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Methanol
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Substance:
piperine (RF-00000365-NTR)
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Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Piperine
Composition #6: Rao, V. Rama Subba., Suresh, G., Babu, K. Suresh., Raju, S. Satyanarayana., Vardhan, M. V. P. S. Vishnu., Ramakrishna, Sistla., Rao, J. Madhusudana. Novel dimeric amide alkaloids from Piper chaba Hunter: isolation, cytotoxic activity, and their biomimetic synthesis . tetrahedron, 2011, vol. 67, no. 10, p. 1885–1892. DOI: 10.1016/j.tet.2011.01.015.
[
DOI link]
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-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Methanol
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Substance:
Piperidine alkaloids (RF-00004320-PAR)
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Additional substance description:
Piplartine
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Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Piperidine alkaloids (Piplartine)
Composition #7: Kubo, Miwa., Ishii, Rina., Ishino, Yoichi., Harada, Kenichi., Matsui, Nobuaki., Akagi, Masaaki., Kato, Eishin., Hosoda, Shinya., Fukuyama, Yoshiyasu. Evaluation of Constituents of Piper retrofractum Fruits on Neurotrophic Activity. JOURNAL OF NATURAL PRODUCTS, 2013, vol. 76, no. 4, p. 769–773. DOI: 10.1021/np300911b.
[
DOI link]
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Plant part:
Fruit unspecified (as part-nature) (A067D)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Methanol
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Substance:
Alkaloids (RF-00004360-PAR)
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Additional substance description:
piperodione, (2E,12E)-pipertridecadienamide
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Alkaloids (piperodione, (2E,12E)-pipertridecadienamide)
Composition #8: Bao, Narisu., Ochir, Sarangowa., Sun, Zhaorigetu., Borjihan, Gereltu., Yamagishi, Takashi. Occurrence of piperidine alkaloids in Piper species collected in different areas. JOURNAL OF NATURAL MEDICINES, 2014, vol. 68, no. 1, p. 211–214. DOI: 10.1007/s11418-013-0773-0.
[
DOI link]
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Plant part:
Fruit unspecified (as part-nature) (A067D)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
acetone
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Substance:
piperlonguminine (RF-00003999-PAR)
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Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
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Analytical method - additional description:
UPLC
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Result unit:
Milligram/gram (G060A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
1.93
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Internal remarks:
Piperlonguminine
Composition #9: Bao, Narisu., Ochir, Sarangowa., Sun, Zhaorigetu., Borjihan, Gereltu., Yamagishi, Takashi. Occurrence of piperidine alkaloids in Piper species collected in different areas. JOURNAL OF NATURAL MEDICINES, 2014, vol. 68, no. 1, p. 211–214. DOI: 10.1007/s11418-013-0773-0.
[
DOI link]
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Plant part:
Fruit unspecified (as part-nature) (A067D)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
acetone
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Substance:
piperine (RF-00000365-NTR)
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Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
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Analytical method - additional description:
UPLC
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Result unit:
Milligram/gram (G060A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
31.08
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Internal remarks:
piperine
Composition #10: Hieu, Le D., Thang, Tran D., Hoi, Tran M., Ogunwande, Isiaka A. Chemical Composition of Essential Oils from Four Vietnamese Species of Piper (Piperaceae) . journal of oleo science, 2014, vol. 63, no. 3, p. 211–217. DOI: 10.5650/jos.ess13175.
[
DOI link]
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Drying (dehydration) (A07KG)
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Additional extraction description:
hydrodistilation
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Substance:
myrcene (RF-00003503-PAR)
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Analytical method code:
GC-MS (F046A)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
14.4
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Internal remarks:
Myrcene
Endpoint study
#1: Jaijoy, K., Vannasiri, S., Piyabhan, P., Lerdvuthisopon, N., Boonraeng, S., Khonsung, P., Lertprasertsuke, N., Sireeratawong, S. Acute and subchronic toxicity study of the water extract from the fruits of Piper chaba hunter in rats. International Journal of Applied Research in Natural Products, 2010, vol. 3, no. 4, p. 29–35. .
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Study relevance:
Human health
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Plant part:
Fruit unspecified (as part-nature) (A067D)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
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Additional plant/substance description:
Water
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Type of toxicological test:
subchronic (CHD013TT)
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Tested organism:
Rat (as animal) (A0CNV)
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Strain of test organism:
Sprague-Dawley (CHD012ST)
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Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
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Unit of exposure duration:
Day (G134A)
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Number of organisms dosed:
10
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Endpoint measured:
Concentration level (CHD013EP)
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Concentration unit:
Milligrams per kilogram body weight per day (G211A)
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Effect concentration:
300
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Critical effect:
Other toxicities (TOX19A)
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Effect description:
Lower body weight and body weight gain in all dosed male groups.
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Effect or parameter linked to the endpoint:
body weight (CHD005BE)
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Internal remarks:
Lower body weight and body weight gain in all dosed male groups.
Endpoint study
#2: Jaijoy, K., Vannasiri, S., Piyabhan, P., Lerdvuthisopon, N., Boonraeng, S., Khonsung, P., Lertprasertsuke, N., Sireeratawong, S. Acute and subchronic toxicity study of the water extract from the fruits of Piper chaba hunter in rats. International Journal of Applied Research in Natural Products, 2010, vol. 3, no. 4, p. 29–35. .
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Study relevance:
Human health
-
Plant part:
Fruit unspecified (as part-nature) (A067D)
-
Preparation/Extraction method:
Solvent extraction (A0BZR)
-
Additional plant/substance description:
Water
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Type of toxicological test:
subchronic (CHD013TT)
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Tested organism:
Rat (as animal) (A0CNV)
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Strain of test organism:
Sprague-Dawley (CHD012ST)
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-
Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
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-
Unit of exposure duration:
Day (G134A)
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Number of organisms dosed:
10
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Endpoint measured:
Concentration level (CHD013EP)
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Concentration unit:
Milligrams per kilogram body weight per day (G211A)
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Effect concentration:
300
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Critical effect:
NEPHROTOXICITY (TOX03A)
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Target tissue:
urogenital: Kidneys (TT046A)
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Effect description:
Lower kidney weight in all dosed female groups.
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Effect or parameter linked to the endpoint:
organ weights (CHD012BE)
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Internal remarks:
Lower kidney weight in all dosed female groups.
Endpoint study
#3: Jaijoy, K., Vannasiri, S., Piyabhan, P., Lerdvuthisopon, N., Boonraeng, S., Khonsung, P., Lertprasertsuke, N., Sireeratawong, S. Acute and subchronic toxicity study of the water extract from the fruits of Piper chaba hunter in rats. International Journal of Applied Research in Natural Products, 2010, vol. 3, no. 4, p. 29–35. .
-
Study relevance:
Human health
-
Plant part:
Fruit unspecified (as part-nature) (A067D)
-
Preparation/Extraction method:
Solvent extraction (A0BZR)
-
Additional plant/substance description:
Water
-
Type of toxicological test:
subchronic (CHD013TT)
-
Tested organism:
Rat (as animal) (A0CNV)
-
Strain of test organism:
Sprague-Dawley (CHD012ST)
-
-
Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
-
-
Unit of exposure duration:
Day (G134A)
-
Number of organisms dosed:
10
-
-
Endpoint measured:
Concentration level (CHD013EP)
-
Concentration unit:
Milligrams per kilogram body weight per day (G211A)
-
Effect concentration:
300
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Critical effect:
PULMONARY AND CARDIAC (TOX08A)
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Target tissue:
cardiovascular / haematological: Heart (TT011A)
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Effect description:
Lower heart weight in all dosed male groups.
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Effect or parameter linked to the endpoint:
organ weights (CHD012BE)
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Internal remarks:
Lower heart weight in all dosed male groups.