EFSA Compendium of Botanicals

Draft - work in progress

Piper kadsura (Choisy) Ohwi

Family:: Piperaceae
Approval state:: Approved
Number of articles retrieved:: 129
Number of processed references:: 3

Compositions

#1: Neolignans (kadsurenin C, kadsurenin H) #2: Neolignans ( denudatin A, piperkadsin C) #3: Total lignans #4: kadsurenone

Endpoint Studies

Genotoxicity

Composition #1: Jiang, RW., Mak, TCW., Fung, KP. Molecular structures of two bicyclo-(3.2.1)-octanoid neolignans from Piper kadsura. JOURNAL OF MOLECULAR STRUCTURE, 2003, vol. 654, no. 1-3, p. 177–182. DOI: 10.1016/S0022-2860(03)00221-7. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Additional extraction description:

unspecified
Substance:

neolignans (RF-00004386-PAR)
Additional substance description:

kadsurenin C and H
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

single-crystal X-ray analysis
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Neolignans (kadsurenin C, kadsurenin H)

Composition #2: Kim, Ki Hyun., Choi, Jung Wook., Ha, Sang Keun., Kim, Sun Yeou., Lee, Kang Ro. Neolignans from Piper kadsura and their anti-neuroinflammatory activity. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, vol. 20, no. 1, p. 409–412. DOI: 10.1016/j.bmcl.2009.10.016. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

neolignans (RF-00004386-PAR)
Additional substance description:

denudatin A, piperkadsin C
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Neolignans ( denudatin A, piperkadsin C)

Composition #3: Cai, Cheng-Cheng., Yan, Ma-Cheng., Xie, Hui., Pan, Sheng-Li. Simultaneous Determination of Ten Active Components in 12 Chinese Piper Species by HPLC. AMERICAN JOURNAL OF CHINESE MEDICINE, 2011, vol. 39, no. 5, p. 1043–1060. DOI: 10.1142/S0192415X11009391. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

lignans, total lignans, total (RF-00000322-NTR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.395
Internal remarks:

Total lignans

Composition #4: Cai, Cheng-Cheng., Yan, Ma-Cheng., Xie, Hui., Pan, Sheng-Li. Simultaneous Determination of Ten Active Components in 12 Chinese Piper Species by HPLC. AMERICAN JOURNAL OF CHINESE MEDICINE, 2011, vol. 39, no. 5, p. 1043–1060. DOI: 10.1142/S0192415X11009391. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

Kadsurenone (RF-00011063-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.288
Internal remarks:

kadsurenone