EFSA Compendium of Botanicals

Draft - work in progress

Piper hispidum Sw. // Piper asperifolium Rich. // Piper asperifolium Ruiz & Pav.

Family:: Piperaceae
Approval state:: Approved
Number of articles retrieved:: 94
Number of processed references:: 4

Compositions

#1: Dillapiole (root, quantified) #2: Apiole (root, quantified) #3: Elemicin (root, quantified) #4: Methylisoeugenol #5: Furan derivatives (stem) #6: furan derivatives (leaf)

Endpoint Studies

Genotoxicity

Composition #1: Facundo, Valdir Alves., Polli, Aline Roberta., Rodrigues, Rosely Valeria., Teixeira Militao, Julio S. L., Stabelli, Rodrigo Guerino., Cardoso, Cosuelo Tamiris. Fixed and volatile chemical constituents from stems and fruits of Piper tuberculatum Jacq. and from roots of P-hispidum H. B. K. . acta amazonica, 2008, vol. 38, no. 4, p. 743–748. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Dillapiole (RF-00004277-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

57.5
Internal remarks:

Dillapiole (root, quantified)

Composition #2: Facundo, Valdir Alves., Polli, Aline Roberta., Rodrigues, Rosely Valeria., Teixeira Militao, Julio S. L., Stabelli, Rodrigo Guerino., Cardoso, Cosuelo Tamiris. Fixed and volatile chemical constituents from stems and fruits of Piper tuberculatum Jacq. and from roots of P-hispidum H. B. K. . acta amazonica, 2008, vol. 38, no. 4, p. 743–748. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

apiole (RF-00003690-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

10.2
Internal remarks:

Apiole (root, quantified)

Composition #3: Facundo, Valdir Alves., Polli, Aline Roberta., Rodrigues, Rosely Valeria., Teixeira Militao, Julio S. L., Stabelli, Rodrigo Guerino., Cardoso, Cosuelo Tamiris. Fixed and volatile chemical constituents from stems and fruits of Piper tuberculatum Jacq. and from roots of P-hispidum H. B. K. . acta amazonica, 2008, vol. 38, no. 4, p. 743–748. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

elemicin (RF-00003787-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

24.5
Internal remarks:

Elemicin (root, quantified)

Composition #4: Cruz, S.M., Cáceres, A., Álvarez, L.E., Apel, M.A., Henriques, A.T. Chemical diversity of essential oils of 15 Piper species from guatemala. acta horticulturae, 2012, vol. 964, p. 39–46. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

methylisoeugenol (RF-00003493-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

4.1
Internal remarks:

Methylisoeugenol

Composition #5: Friedrich, U., Siems, K., Solis, PN., Gupta, MP., Jenett-Siems, K. New prenylated benzoic acid derivatives of Piper hispidum. PHARMAZIE, 2005, vol. 60, no. 6, p. 455–457. .

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

furan derivatives (RF-00004396-PAR)
Additional substance description:

3-Hydroxy-2-(1-hydroxy-1-methylethyl)-2,3-dihydrobenzofuran-5-carboxylic acid, 3-Hydroxy-2-(1-hydroxy-1-methylethyl)-2,3-dihydrobenzofuran-5-carboxylic acid methyl ester
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Furan derivatives (stem)

Composition #6: Michel, Joanna L., Chen, Yegao., Zhang, Hongjie., Huang, Yue., Krunic, Aleksej., Orjala, Jimmy., Veliz, Mario., Soni, Kapil K., Soejarto, Djaja Doel., Caceres, Armando., Perez, Alice., Mahady, Gail B. Estrogenic and serotonergic butenolides from the leaves of Piper hispidum Swingle (Piperaceae). JOURNAL OF ETHNOPHARMACOLOGY, 2010, vol. 129, no. 2, p. 220–226. DOI: 10.1016/j.jep.2010.03.008. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

furan derivatives (RF-00004396-PAR)
Additional substance description:

piperolide, 5,6-Z-fadyenolide, 9,10-Methylenedioxy-5,6-Z-fadyenolide
Analytical method code:

LC-LR-MS (F330A)
Analytical method - additional description:

NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

furan derivatives (leaf)