Draft - work in progress
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- Otaheite gooseberry (as plant) // Phyllanthus acidus (L.) Skeels
Otaheite gooseberry (as plant) // Phyllanthus acidus (L.) Skeels
- Family:
- Phyllanthaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 123
- Number of processed references:
- 5
Composition #1: Durham, DG., Reid, RG., Wangboonskul, J., Daodee, S. Extraction of phyllanthusols A and B from Phyllanthus acidus and analysis by capillary electrophoresis. PHYTOCHEMICAL ANALYSIS, 2002, vol. 13, no. 6, p. 358–362. DOI: 10.1002/pca.668.
[
DOI link]
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
ethanol
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Substance:
furan derivatives (RF-00004396-PAR)
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Additional substance description:
Phyllanthusols A and B
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Analytical method code:
Capillary (Zone) Electrophoresis (CE or CZE) (F071A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Furan derivatives (phyllanthusols A and B)
Composition #2: Liliwirianis, N., Musa, Nor Lailatul Wahidah., Zain, Wan Zuraida Wan Mohd., Kassim, Jamaluddin., Karim, Syaikh Abdul. Premilinary Studies on Phytochemical Screening of Ulam and Fruit from Malaysia. E-JOURNAL OF CHEMISTRY, 2011, vol. 8, p. S285–S288. .
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
methanol
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Substance:
Saponins (RF-00004333-PAR)
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Analytical method code:
Phytochemical screening (F604A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Saponins (leaves)
Composition #3: Liliwirianis, N., Musa, Nor Lailatul Wahidah., Zain, Wan Zuraida Wan Mohd., Kassim, Jamaluddin., Karim, Syaikh Abdul. Premilinary Studies on Phytochemical Screening of Ulam and Fruit from Malaysia. E-JOURNAL OF CHEMISTRY, 2011, vol. 8, p. S285–S288. .
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Plant part:
Aerial part of plants (as part-nature) (A166F)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
methanol
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Substance:
Alkaloids (RF-00004360-PAR)
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Analytical method code:
Phytochemical screening (F604A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Alkaloids (stem, leaves)
Endpoint study
#1: Vikasari, S.N., Sukandar, E.Y., Sutjiatmo, A.B., Riyanti, S. Diuretic effect of the ethanol extracts of phyllanthus acidus l (skeels) leaves in wistar rats. International Journal of Pharmacy and Pharmaceutical Sciences, 2015, vol. 7, no. 1, p. 120–123. .
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Study relevance:
Human health
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Plant part:
Leaves (as part-nature) (A0EKT)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
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Additional plant/substance description:
ethanol
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Type of toxicological test:
other (CHD008TT)
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Limit test:
Not applicable
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Tested organism:
Rat (as animal) (A0CNV)
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Strain of test organism:
Wistar (CHD013ST)
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Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
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Number of organisms dosed:
25
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Endpoint measured:
Dose level (CHD014EP)
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Concentration unit:
Milligrams per kilogram body weight (G225A)
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Effect concentration:
22.5
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Critical effect:
NEPHROTOXICITY (TOX03A)
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Target tissue:
urogenital: Kidneys (TT046A)
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Effect description:
ethanol leaf extract orally at doses of 22.5 mg/kg bw, 45 mg/kg bw and 90 mg/kg bw had significantly diuretic effect compared to control group (P<0.05), but less than furosemid 3.6 mg/kg bw (P<0.05).
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Effect or parameter linked to the endpoint:
urinalysis (CHD029BE)
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Internal remarks:
diuretic effect of ethanol leaf extract orally
Endpoint study
#2: Chongsa, Watchara., Radenahmad, Nisaudah., Jansakul, Chaweewan. Six weeks oral gavage of a Phyllanthus acidus leaf water extract decreased visceral fat, the serum lipid profile and liver lipid accumulation in middle-aged male rats. JOURNAL OF ETHNOPHARMACOLOGY, 2014, vol. 155, no. 1, p. 396–404. DOI: 10.1016/j.jep.2014.05.039.
[
DOI link]
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Study relevance:
Human health
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Plant part:
Leaves (as part-nature) (A0EKT)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
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Additional plant/substance description:
cold water, heated water resp. butanol
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Type of toxicological test:
short-term toxicity (CHD017TT)
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Limit test:
Not applicable
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Tested organism:
Rat (as animal) (A0CNV)
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Strain of test organism:
Wistar (CHD013ST)
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Route of exposure:
ORAL: GAVAGE (OECD2231PL)
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Unit of exposure duration:
Week (G205A)
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Number of organisms dosed:
50
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Endpoint measured:
Dose level (CHD014EP)
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Concentration unit:
Grams per kilogram body weight (G226A)
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Critical effect:
Digestive (TOX18A)
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Target tissue:
Digestive (TT002A)
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Effect description:
Cold water extract of leaves reduced weight and decreased adipose tissue in middle-aged male rats. Lipid accumulation in liver
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Effect or parameter linked to the endpoint:
body weight (CHD005BE)
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Internal remarks:
Phyllanthus acidus leaf cold water extract reduced weight and decreased adipose tissue in middle-aged male rats
Endpoint study
#3: Borah, A., Devi, D. Neuropharmacological effects of Phyllanthus acidus in swiss albino mice. indian journal of pharmacology, 2014, vol. 46, p. S46–S46. .
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Study relevance:
Human health
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Plant part:
Leaves (as part-nature) (A0EKT)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
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Additional plant/substance description:
ethanol
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Type of toxicological test:
other (CHD008TT)
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Limit test:
Not applicable
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Tested organism:
House mouse (as animal) (A0CNT)
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Strain of test organism:
Swiss (CHD005ST)
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Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
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Control groups used:
no data
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Endpoint measured:
Dose not reported (CHD066EP)
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Critical effect:
NEUROTOXICITY (TOX04A)
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Target tissue:
neurologic: Central Nervous System (TT035A)
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Effect description:
neuropharmacological effect
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Effect or parameter linked to the endpoint:
behaviour (CHD001BE)
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Internal remarks:
Neuropharmacological effect of ethanol extract from leaves
