EFSA Compendium of Botanicals

Draft - work in progress

Phellodendron chinense C.K.Schneid.

Family:: Rutaceae
Approval state:: Approved
Number of articles retrieved:: 312
Number of processed references:: 4

Endpoint Studies

Genotoxicity

Composition #1: Zhu, Shuang-lai., Dou, Sheng-shan., Liu, Xin-ru., Liu, Run-hui., Zhang, Wei-dong., Huang, Hong-lin., Zhang, Yi., Hu, Yao-hua., Wang, Shu-ping. Qualitative and quantitative analysis of alkaloids in Cortex Phellodendri by HPLC-ESI-MS/MS and HPLC-DAD. Chemical Research in Chinese Universities, 2011, p. 38–44. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

magnoflorine (RF-00003919-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

HPLC-DAD, HPLC-MS/MS
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.73 - 6.68
Internal remarks:

Magnoflorine

Composition #2: Zhu, Shuang-lai., Dou, Sheng-shan., Liu, Xin-ru., Liu, Run-hui., Zhang, Wei-dong., Huang, Hong-lin., Zhang, Yi., Hu, Yao-hua., Wang, Shu-ping. Qualitative and quantitative analysis of alkaloids in Cortex Phellodendri by HPLC-ESI-MS/MS and HPLC-DAD. Chemical Research in Chinese Universities, 2011, p. 38–44. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

jatrorrhizine (RF-00003887-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

HPLC-DAD, HPLC-MS/MS
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.21-0.60
Internal remarks:

Jatrorrhizine

Composition #3: Zhu, Shuang-lai., Dou, Sheng-shan., Liu, Xin-ru., Liu, Run-hui., Zhang, Wei-dong., Huang, Hong-lin., Zhang, Yi., Hu, Yao-hua., Wang, Shu-ping. Qualitative and quantitative analysis of alkaloids in Cortex Phellodendri by HPLC-ESI-MS/MS and HPLC-DAD. Chemical Research in Chinese Universities, 2011, p. 38–44. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

palmatine (RF-00003971-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

HPLC-DAD, HPLC-MS/MS
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.13-0.43
Internal remarks:

Palmatine

Composition #4: Zhu, Shuang-lai., Dou, Sheng-shan., Liu, Xin-ru., Liu, Run-hui., Zhang, Wei-dong., Huang, Hong-lin., Zhang, Yi., Hu, Yao-hua., Wang, Shu-ping. Qualitative and quantitative analysis of alkaloids in Cortex Phellodendri by HPLC-ESI-MS/MS and HPLC-DAD. Chemical Research in Chinese Universities, 2011, p. 38–44. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

berberine (RF-00003706-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

HPLC-DAD, HPLC-MS/MS
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

19.06-74.25
Internal remarks:

Berberine

Composition #5: Zhu, Shuang-lai., Dou, Sheng-shan., Liu, Xin-ru., Liu, Run-hui., Zhang, Wei-dong., Huang, Hong-lin., Zhang, Yi., Hu, Yao-hua., Wang, Shu-ping. Qualitative and quantitative analysis of alkaloids in Cortex Phellodendri by HPLC-ESI-MS/MS and HPLC-DAD. Chemical Research in Chinese Universities, 2011, p. 38–44. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

Phellodendrine
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

HPLC-DAD, HPLC-MS/MS
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.53-2.69
Internal remarks:

Phellodendrine

Composition #6: Liu, Y.-M., Sheu, S.-J., Chiou, S.-H., Chang, H.-C., Chen, Y.-P. A comparative study on commercial samples of Phellodendri cortex. Planta Medica, 1993, vol. 59, no. 6, p. 557–561. DOI: 10.1055/s-2006-959761. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH (70%)
Substance:

jatrorrhizine (RF-00003887-PAR)
Analytical method code:

Capillary (Zone) Electrophoresis (CE or CZE) (F071A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.2
Internal remarks:

Jatrorrhizine

Composition #7: Liu, Y.-M., Sheu, S.-J., Chiou, S.-H., Chang, H.-C., Chen, Y.-P. A comparative study on commercial samples of Phellodendri cortex. Planta Medica, 1993, vol. 59, no. 6, p. 557–561. DOI: 10.1055/s-2006-959761. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH (70%)
Substance:

magnoflorine (RF-00003919-PAR)
Analytical method code:

Capillary (Zone) Electrophoresis (CE or CZE) (F071A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

5
Internal remarks:

Magnoflorine

Composition #8: Liu, Y.-M., Sheu, S.-J., Chiou, S.-H., Chang, H.-C., Chen, Y.-P. A comparative study on commercial samples of Phellodendri cortex. Planta Medica, 1993, vol. 59, no. 6, p. 557–561. DOI: 10.1055/s-2006-959761. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH (70%)
Substance:

palmatine (RF-00003971-PAR)
Analytical method code:

Capillary (Zone) Electrophoresis (CE or CZE) (F071A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.4
Internal remarks:

Palmatine

Composition #9: Liu, Y.-M., Sheu, S.-J., Chiou, S.-H., Chang, H.-C., Chen, Y.-P. A comparative study on commercial samples of Phellodendri cortex. Planta Medica, 1993, vol. 59, no. 6, p. 557–561. DOI: 10.1055/s-2006-959761. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH (70%)
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

Phellodendrine
Analytical method code:

Capillary (Zone) Electrophoresis (CE or CZE) (F071A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1
Internal remarks:

Phellodendrine

Composition #10: Liu, Y.-M., Sheu, S.-J., Chiou, S.-H., Chang, H.-C., Chen, Y.-P. A comparative study on commercial samples of Phellodendri cortex. Planta Medica, 1993, vol. 59, no. 6, p. 557–561. DOI: 10.1055/s-2006-959761. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH (70%)
Substance:

berberine (RF-00003706-PAR)
Analytical method code:

Capillary (Zone) Electrophoresis (CE or CZE) (F071A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

5.7
Internal remarks:

Berberine

Composition #11: Xu, Xueqin., Lin, Qiang., He, Xiaoyan., Fu, FengFu., Chen, Guonan. Determination of protoberberine alkaloids in medicinal plants based on acidic potassium permanganate chemiluminescence system. LUMINESCENCE, 2010, vol. 25, no. 5, p. 403–408. DOI: 10.1002/bio.1169. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH
Substance:

jatrorrhizine (RF-00003887-PAR)
Analytical method code:

UV/VIS spectroscopy (photometry) (F009A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Jatrorrhizine

Composition #12: Xu, Xueqin., Lin, Qiang., He, Xiaoyan., Fu, FengFu., Chen, Guonan. Determination of protoberberine alkaloids in medicinal plants based on acidic potassium permanganate chemiluminescence system. LUMINESCENCE, 2010, vol. 25, no. 5, p. 403–408. DOI: 10.1002/bio.1169. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH
Substance:

berberine (RF-00003706-PAR)
Analytical method code:

UV/VIS spectroscopy (photometry) (F009A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Berberine

Composition #13: Xu, Xueqin., Lin, Qiang., He, Xiaoyan., Fu, FengFu., Chen, Guonan. Determination of protoberberine alkaloids in medicinal plants based on acidic potassium permanganate chemiluminescence system. LUMINESCENCE, 2010, vol. 25, no. 5, p. 403–408. DOI: 10.1002/bio.1169. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH
Substance:

palmatine (RF-00003971-PAR)
Analytical method code:

UV/VIS spectroscopy (photometry) (F009A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Palmatine

Composition #14: Liu, Yong., Chen, Juan., Li, Xue-Hu., Shi, Yan-Ping. Simultaneous Determination of Seven Alkaloids in Phellodendron chinense Schneid by High-Performance Liquid Chromatography . journal of aoac international, 2010, vol. 93, no. 5, p. 1416–1421. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

berberine (RF-00003706-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Microgram/gram (G049A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

610
Internal remarks:

Berberine

Composition #15: Liu, Yong., Chen, Juan., Li, Xue-Hu., Shi, Yan-Ping. Simultaneous Determination of Seven Alkaloids in Phellodendron chinense Schneid by High-Performance Liquid Chromatography . journal of aoac international, 2010, vol. 93, no. 5, p. 1416–1421. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

Quinoline alkaloids (RF-00004326-PAR)
Additional substance description:

(-)-(R)-Platydesmin
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Microgram/gram (G049A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

46
Internal remarks:

(-)-(R)-Platydesmin

Composition #16: Liu, Yong., Chen, Juan., Li, Xue-Hu., Shi, Yan-Ping. Simultaneous Determination of Seven Alkaloids in Phellodendron chinense Schneid by High-Performance Liquid Chromatography . journal of aoac international, 2010, vol. 93, no. 5, p. 1416–1421. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

Noroxyhydrastinine (RF-00011424-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Microgram/gram (G049A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

44
Internal remarks:

Noroxyhydrastinine

Composition #17: Liu, Yong., Chen, Juan., Li, Xue-Hu., Shi, Yan-Ping. Simultaneous Determination of Seven Alkaloids in Phellodendron chinense Schneid by High-Performance Liquid Chromatography . journal of aoac international, 2010, vol. 93, no. 5, p. 1416–1421. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

skimmianine (RF-00004057-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Microgram/gram (G049A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

15
Internal remarks:

Skimmianine

Composition #18: Liu, Yong., Chen, Juan., Li, Xue-Hu., Shi, Yan-Ping. Simultaneous Determination of Seven Alkaloids in Phellodendron chinense Schneid by High-Performance Liquid Chromatography . journal of aoac international, 2010, vol. 93, no. 5, p. 1416–1421. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

canthin-6-one (RF-00003726-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Microgram/gram (G049A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

31
Internal remarks:

Canthin-6-one

Composition #19: Liu, Yong., Chen, Juan., Li, Xue-Hu., Shi, Yan-Ping. Simultaneous Determination of Seven Alkaloids in Phellodendron chinense Schneid by High-Performance Liquid Chromatography . journal of aoac international, 2010, vol. 93, no. 5, p. 1416–1421. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

indole alkaloids (RF-00004503-PAR)
Additional substance description:

chilenine
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Microgram/gram (G049A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

38
Internal remarks:

Chilenine

Composition #20: Liu, Yong., Chen, Juan., Li, Xue-Hu., Shi, Yan-Ping. Simultaneous Determination of Seven Alkaloids in Phellodendron chinense Schneid by High-Performance Liquid Chromatography . journal of aoac international, 2010, vol. 93, no. 5, p. 1416–1421. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

ptelein (RF-00004017-PAR)
Additional substance description:

pteleine
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Microgram/gram (G049A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

21
Internal remarks:

Pteleine