EFSA Compendium of Botanicals

Draft - work in progress

Peucedanum praeruptorum Dunn

Family:: Apiaceae
Approval state:: Approved
Number of articles retrieved:: 307
Number of processed references:: 6

Compositions

#1: Total coumarins in roots #2: Praeruptorins A (Pyranocoumarin) #3: Coumarins #4: Coumarins (Peucedanocoumarin I, Qianhucoumarin H) #5: Isoscopoletin #6: Umbelliferone #7: Qianhucoumarin I (pyranocoumarin) #8: Falcarindiol

Endpoint Studies

Genotoxicity

Composition #1: Zhang, Xiuqin., Xu, Lixin. Determination of coumarins in Qian Hu. zhongyao tongbao, 1984, p. 79–81. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOAc
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

total coumarins
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.59
Internal remarks:

Total coumarins in roots

Composition #2: Wang, C., Chang, TH., Zhang, XH., Wang, HL. Effects of dl-praeruptorin A on nucleus factor-kappa B and tumor necrosis factor-alpha expression in ischemia-reperfusion hearts . acta pharmacologica sinica, 2004, vol. 25, no. 1, p. 35–40. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Unspecified
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

Praeruptorin A (pyranocoumarin)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Praeruptorins A (Pyranocoumarin)

Composition #3: Ishii, Hirotaka., Okada, Yoshihito., Baba, Masaki., Okuyama, Toru. Studies of coumarins from the Chinese drug Qianhu, XXVII: Structure of a new simple coumarin glycoside from Bai-Hua Qianhu, Peucedanum praeruptorum. CHEMICAL & PHARMACEUTICAL BULLETIN, 2008, vol. 56, no. 9, p. 1349–1351. DOI: 10.1248/cpb.56.1349. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

Praeroside VI, apiosylskimmin, hymexelsin, umbelliferone, scopoletin, isofraxidin and 8-carboxy-7-hydroxy coumarin
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

column chromatography
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Coumarins

Composition #4: Kong, LY., Li, Y., Min, ZD., Li, X., Zhu, TR. Coumarins from Peucedanum praeruptorum. PHYTOCHEMISTRY, 1996, vol. 41, no. 5, p. 1423–1426. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Hydrocarbons
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

Peucedanocoumarin I, Qianhucoumarin H
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, MS, HPLC-UV, IR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Coumarins (Peucedanocoumarin I, Qianhucoumarin H)

Composition #5: Kong, LY., Li, Y., Min, ZD., Li, X., Zhu, TR. Coumarins from Peucedanum praeruptorum. PHYTOCHEMISTRY, 1996, vol. 41, no. 5, p. 1423–1426. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Hydrocarbons
Substance:

Isoscopoletin (RF-00010985-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

spectroscopic techniques: NMR, IR, MS; HPLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isoscopoletin

Composition #6: Kong, LY., Li, Y., Min, ZD., Li, X., Zhu, TR. Coumarins from Peucedanum praeruptorum. PHYTOCHEMISTRY, 1996, vol. 41, no. 5, p. 1423–1426. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Hydrocarbons
Substance:

umbelliferone (RF-00004096-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, MS, IR; HPLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Umbelliferone

Composition #7: Kong, LY., Min, ZD., Li, Y., Li, X., Pei, YH. Qianhucoumarin I from Peucedanum praeruptorum. PHYTOCHEMISTRY, 1996, vol. 42, no. 6, p. 1689–1691. DOI: 10.1016/0031-9422(96)00178-1. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Petrolem
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

qianhucoumarin I (pyranocoumarin)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

spectroscopic techniques
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Qianhucoumarin I (pyranocoumarin)

Composition #8: Miyazawa, M., Shimamura, H., Bhuva, RC., Nakamura, S., Kameoka, H. Antimutagenic activity of falcarindiol from Peucedanum praeruptorum. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1996, vol. 44, no. 11, p. 3444–3448. DOI: 10.1021/jf960025a. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

falcarindiol (RF-00003811-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

EI-MS, IR, 1H and 13C NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Falcarindiol