EFSA Compendium of Botanicals

Draft - work in progress

Petasites frigidus (L.) Fr.

Family:: Asteraceae
Approval state:: Approved
Number of articles retrieved:: 28
Number of processed references:: 2

Compositions

#1: 8-H-eremophilanolide #2: Pyrrolizidine alkaloids #3: Senecionine #4: Senecionine-N-oxide #5: Senkirkine #6: Intergerrimine

Endpoint Studies

Genotoxicity

Composition #1: Avula, Bharathi., Wang, Yan-Hong., Wang, Mei., Smillie, Troy J., Khan, Ikhlas A. Simultaneous determination of sesquiterpenes and pyrrolizidine alkaloids from the rhizomes of Petasites hybridus (L.) G.M. et Sch. and dietary supplements using UPLC-UV and HPLC-TOF-MS methods. Journal of Pharmaceutical and Biomedical Analysis, 2012, p. 53–63. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Additional extraction description:

unspecified
Substance:

Sesquiterpene lactones (RF-00004319-PAR)
Additional substance description:

8- H-eremophilanolide
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.01
Internal remarks:

8-H-eremophilanolide

Composition #2: Avula, Bharathi., Wang, Yan-Hong., Wang, Mei., Smillie, Troy J., Khan, Ikhlas A. Simultaneous determination of sesquiterpenes and pyrrolizidine alkaloids from the rhizomes of Petasites hybridus (L.) G.M. et Sch. and dietary supplements using UPLC-UV and HPLC-TOF-MS methods. Journal of Pharmaceutical and Biomedical Analysis, 2012, p. 53–63. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Additional extraction description:

unspecified
Substance:

Pyrrolizidine alkaloids (RF-00000230-TOX)
Additional substance description:

integerrimine, senecionine, integerrimine N-oxide, senecionine N-oxide, senkirkin
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

HPLC-MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Pyrrolizidine alkaloids

Composition #3: Avula, Bharathi., Sagi, Satyanarayanaraju., Wang, Yan-Hong., Zweigenbaum, Jerry., Wang, Mei., Khan, Ikhlas A. Characterization and screening of pyrrolizidine alkaloids and N-oxides from botanicals and dietary supplements using UHPLC-high resolution mass spectrometry. Food Chemistry, 2015, p. 136–148. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MEOH
Substance:

Senecionine (RF-00000232-TOX)
Analytical method code:

HPLC with standard detection methods (F019A)
Analytical method - additional description:

UHPLC/QToF-MS
Result unit:

Nanogram/gram (G076A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

120
Internal remarks:

Senecionine
completed:

True

Composition #4: Avula, Bharathi., Sagi, Satyanarayanaraju., Wang, Yan-Hong., Zweigenbaum, Jerry., Wang, Mei., Khan, Ikhlas A. Characterization and screening of pyrrolizidine alkaloids and N-oxides from botanicals and dietary supplements using UHPLC-high resolution mass spectrometry. Food Chemistry, 2015, p. 136–148. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

Senecionine-N-oxide (RF-00000361-TOX)
Analytical method code:

HPLC with standard detection methods (F019A)
Analytical method - additional description:

UHPLC/QToF-MS
Result unit:

Nanogram/gram (G076A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

260
Internal remarks:

Senecionine-N-oxide
completed:

True

Composition #5: Avula, Bharathi., Sagi, Satyanarayanaraju., Wang, Yan-Hong., Zweigenbaum, Jerry., Wang, Mei., Khan, Ikhlas A. Characterization and screening of pyrrolizidine alkaloids and N-oxides from botanicals and dietary supplements using UHPLC-high resolution mass spectrometry. Food Chemistry, 2015, p. 136–148. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

Senkirkine (RF-00000300-TOX)
Analytical method code:

HPLC with standard detection methods (F019A)
Analytical method - additional description:

UHPLC/QToF-MS
Result unit:

Nanogram/gram (G076A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3000
Internal remarks:

Senkirkine
completed:

True

Composition #6: Avula, Bharathi., Sagi, Satyanarayanaraju., Wang, Yan-Hong., Zweigenbaum, Jerry., Wang, Mei., Khan, Ikhlas A. Characterization and screening of pyrrolizidine alkaloids and N-oxides from botanicals and dietary supplements using UHPLC-high resolution mass spectrometry. Food Chemistry, 2015, p. 136–148. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

Integerrimine (RF-00000285-TOX)
Analytical method code:

HPLC with standard detection methods (F019A)
Analytical method - additional description:

UHPLC/QToF-MS
Result unit:

Nanogram/gram (G076A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

20
Internal remarks:

Intergerrimine
completed:

True