EFSA Compendium of Botanicals

Draft - work in progress

Petasites albus (L.) Gaertn.

Family:: Asteraceae
Approval state:: Approved
Number of articles retrieved:: 63
Number of processed references:: 6

Compositions

#1: Triterpene saponins #2: alkaloids #3: Bakkenolide A #4: Bakkenolide A in roots #5: Furanoeremophilanes: Petasalbin, Albopetasin,Albopetasol,6-Angeloyl-albopetasol ,6-Senecionyl-albopetasol, #6: Bakkenolide A in buds #7: Senkirkine #8: Petalbusin #9: Benzofurans (petalbin, petalbone)

Endpoint Studies

Genotoxicity

Composition #1: Efimova, F. V., Murav'eva, D. A. Chemical composition of Petasites species of Northern Caucasus. aptechnoe delo, 1965, p. 41–44. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Unspecified
Substance:

Triterpene saponins Triterpene saponins (RF-00004338-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

7.1
Internal remarks:

Triterpene saponins

Composition #2: Efimova, F. V., Murav'eva, D. A. Chemical composition of Petasites species of Northern Caucasus. aptechnoe delo, 1965, p. 41–44. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Unspecified
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Value (concentration, content):

traces
Internal remarks:

alkaloids

Composition #3: Novotny, L., Kotva, K., Toman, J., Herout, V. Terpenes. CCX. Sesquiterpenes from Petasites. Phytochemistry (Elsevier), 1972, p. 2795–2799. .

Language:

English (en)
Plant part:

Bud (as part-nature) (A066Z)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

acetone/benzene
Substance:

Bakkenolide A (RF-00010904-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, UV, IR
Result unit:

Gram/kilogram (G015A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.65
Internal remarks:

Bakkenolide A

Composition #4: Siegenthaler, P., Neuenschwander, M. Analytic investigations of sesquiterpenes of Petasites albus (L.) GAERTN. Pharmaceutica Acta Helvetiae, 1996, vol. 71, no. 5, p. 345–353. DOI: 10.1016/S0031-6865(96)00040-4. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Dichloromethane/PrepMPLC
Substance:

Bakkenolide A (RF-00010904-PAR)
Analytical method code:

HPLC-DAD (F587A)
Analytical method - additional description:

NMR, MS, HPLC-UV, UV, IR
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

36
Internal remarks:

Bakkenolide A in roots

Composition #5: Siegenthaler, P., Neuenschwander, M. Analytic investigations of sesquiterpenes of Petasites albus (L.) GAERTN. Pharmaceutica Acta Helvetiae, 1996, vol. 71, no. 5, p. 345–353. DOI: 10.1016/S0031-6865(96)00040-4. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Dichloromethane/PrepMPLC
Substance:

furan derivatives (RF-00004396-PAR)
Additional substance description:

Furanoeremophylanes: Petasalbin, Albopetasin, Albopetasol, 6-Angeloyl-albopetasol ,6-Senecionyl-albopetasol
Analytical method code:

HPLC-DAD (F587A)
Analytical method - additional description:

NMR, MS, HPLC-UV, UV, IR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Furanoeremophilanes: Petasalbin, Albopetasin,Albopetasol,6-Angeloyl-albopetasol ,6-Senecionyl-albopetasol,

Composition #6: Siegenthaler, P., Neuenschwander, M. Analytic investigations of sesquiterpenes of Petasites albus (L.) GAERTN. Pharmaceutica Acta Helvetiae, 1996, vol. 71, no. 5, p. 345–353. DOI: 10.1016/S0031-6865(96)00040-4. [DOI link]

Language:

English (en)
Plant part:

Bud (as part-nature) (A066Z)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Dichloromethane/PrepMPLC
Substance:

Bakkenolide A (RF-00010904-PAR)
Analytical method code:

HPLC-DAD (F587A)
Analytical method - additional description:

NMR, MS, HPLC-UV, UV, IR
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

11
Internal remarks:

Bakkenolide A in buds

Composition #7: Mroczek, T., Glowniak, K., Wlaszczyk, A. Simultaneous determination of N-oxides and free bases of pyrrolizidine alkaloids by canon-exchange solid-phase extraction and ion-pair high-performance liquid chromatography. JOURNAL OF CHROMATOGRAPHY A, 2002, vol. 949, no. 1-2, p. 249–262. DOI: 10.1016/S0021-9673(01)01498-4. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Senkirkine (RF-00000300-TOX)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Milligram/kilogram (G061A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

11.6
Internal remarks:

Senkirkine

Composition #8: Bagirova, U. K., Mamedov, E. I., Serkerov, S. V. CHEMICAL STUDY OF Petasites albus. CHEMISTRY OF NATURAL COMPOUNDS, 2011, vol. 47, no. 3, p. 395–396. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

acetone/column chromatography
Substance:

furan derivatives (RF-00004396-PAR)
Additional substance description:

Petalbusin (Benzofuran)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

physicochemical and spectral (IR, PMR, 13C NMR, 13C DEPT 135) data
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Petalbusin

Composition #9: Bagirova, U. K., Serkerov, S. V. CHEMICAL STUDY OF Petasites albus. CHEMISTRY OF NATURAL COMPOUNDS, 2012, vol. 47, no. 6, p. 891–892. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Unspecified
Substance:

furan derivatives (RF-00004396-PAR)
Additional substance description:

Petalbin, petalbone (benzofurans)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

IR, PMR, 13C NMR, 13C DEPT
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Benzofurans (petalbin, petalbone)