EFSA Compendium of Botanicals

Draft - work in progress

Persicaria hydropiper (L.) Delarbre // Polygonum hydropiper L.

Family:: Polygonaceae
Approval state:: Approved
Number of articles retrieved:: 804
Number of processed references:: 4

Compositions

#1: Camphor #2: Carvone #3: Fenchone #4: Gallic acid #5: saponins #6: tannins

Endpoint Studies

#1: very slight hepatotoxicity #2: very slight nephrotoxicity #3: haemolytic anemia

Genotoxicity

Composition #1: Yankov, Lyuben K., Damjanova, Lila. Components of Polygonum hydropiper. I. Composition of essential oil. pharmazie, 1969, p. 696–699. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Camphor (RF-00003986-PAR)
Analytical method code:

Gaschromatography (GC) (F037A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Camphor

Composition #2: Yankov, Lyuben K., Damjanova, Lila. Components of Polygonum hydropiper. I. Composition of essential oil. pharmazie, 1969, p. 696–699. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Carvone (RF-0538-001-PPP)
Analytical method code:

Gaschromatography (GC) (F037A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Carvone

Composition #3: Yankov, Lyuben K., Damjanova, Lila. Components of Polygonum hydropiper. I. Composition of essential oil. pharmazie, 1969, p. 696–699. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

fenchone (RF-00003814-PAR)
Analytical method code:

Gaschromatography (GC) (F037A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Fenchone

Composition #4: Huang, Jian., Hou, Pengyi., Wu, Lijun., Gao, Huiyuan. Isolation and identification of chemical constituents from whole plant of Polygonum hydropiper L.. shenyang yaoke daxue xuebao, 2012, p. 22–25. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol 75%
Substance:

gallic acid (RF-00003821-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

column chromatography + NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Gallic acid

Composition #5: Hydropiper, P., Sharif, S., Ahmed, T., Aminul Haque, M., Bhuiyan, M.A., Shahriar, M. Phytochemical screenings, thrombolytic activity, membrane stabilizing activity and cytotoxic properties of Polygonum hydropiper. Research Journal of Medicinal Plant, 2014, vol. 8, no. 2, p. 92–98. DOI: 10.3923/rjmp.2014.92.98. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol, ethanol, chloroform, ether, and h-hexane
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

saponins

Composition #6: Hydropiper, P., Sharif, S., Ahmed, T., Aminul Haque, M., Bhuiyan, M.A., Shahriar, M. Phytochemical screenings, thrombolytic activity, membrane stabilizing activity and cytotoxic properties of Polygonum hydropiper. Research Journal of Medicinal Plant, 2014, vol. 8, no. 2, p. 92–98. DOI: 10.3923/rjmp.2014.92.98. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol, ethanol
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

tannins

Endpoint study #1: Kuroiwa, Keiko., Shibutani, Makoto., Inoue, Kaoru., Lee, Kyoung-Youl., Woo, Gye-Hyeong., Hirose, Masao. Subchronic toxicity study of water pepper extract in F344 rats. FOOD AND CHEMICAL TOXICOLOGY, 2006, vol. 44, no. 8, p. 1236–1244. DOI: 10.1016/j.fct.2006.01.020. [DOI link]

Study relevance:

Human health
Plant part:

Leaves (as part-nature) (A0EKT)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

N-hexane
Type of toxicological test:

subchronic (CHD013TT)
Tested organism:

Rat (as animal) (A0CNV)
Sex:

Male/Female
Route of exposure:

ORAL: FEED (OECD2230PL)
Exposure duration:

13.0
Unit of exposure duration:

Week (G205A)
Number of organisms dosed:

100
Control groups used:

yes
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Microgram/millilitre (G052A)
Effect concentration:

4000
Critical effect:

HEPATOTOXICITY (TOX02A)
Target tissue:

digestive: Liver (TT023A)
Effect description:

very slight hepatotoxicity
Effect or parameter linked to the endpoint:

organ weights (CHD012BE)
Internal remarks:

very slight hepatotoxicity

Endpoint study #2: Kuroiwa, Keiko., Shibutani, Makoto., Inoue, Kaoru., Lee, Kyoung-Youl., Woo, Gye-Hyeong., Hirose, Masao. Subchronic toxicity study of water pepper extract in F344 rats. FOOD AND CHEMICAL TOXICOLOGY, 2006, vol. 44, no. 8, p. 1236–1244. DOI: 10.1016/j.fct.2006.01.020. [DOI link]

Study relevance:

Human health
Plant part:

Leaves (as part-nature) (A0EKT)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

N-hexane
Type of toxicological test:

subchronic (CHD013TT)
Tested organism:

Rat (as animal) (A0CNV)
Sex:

Male/Female
Route of exposure:

ORAL: FEED (OECD2230PL)
Exposure duration:

13.0
Unit of exposure duration:

Week (G205A)
Number of organisms dosed:

100
Control groups used:

yes
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Microgram/millilitre (G052A)
Effect concentration:

4000
Critical effect:

NEPHROTOXICITY (TOX03A)
Target tissue:

urogenital: Kidneys (TT046A)
Effect description:

very slight nephrotoxicity
Effect or parameter linked to the endpoint:

organ weights (CHD012BE)
Internal remarks:

very slight nephrotoxicity

Endpoint study #3: Kuroiwa, Keiko., Shibutani, Makoto., Inoue, Kaoru., Lee, Kyoung-Youl., Woo, Gye-Hyeong., Hirose, Masao. Subchronic toxicity study of water pepper extract in F344 rats. FOOD AND CHEMICAL TOXICOLOGY, 2006, vol. 44, no. 8, p. 1236–1244. DOI: 10.1016/j.fct.2006.01.020. [DOI link]

Study relevance:

Human health
Plant part:

Leaves (as part-nature) (A0EKT)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

N-hexane
Type of toxicological test:

subchronic (CHD013TT)
Tested organism:

Rat (as animal) (A0CNV)
Sex:

Male/Female
Route of exposure:

ORAL: FEED (OECD2230PL)
Exposure duration:

13.0
Unit of exposure duration:

Week (G205A)
Number of organisms dosed:

100
Control groups used:

yes
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Microgram/millilitre (G052A)
Effect concentration:

4000
Critical effect:

HEMOPOIETIC (TOX10A)
Target tissue:

Cardiovascular / Haematological (TT001A)
Effect description:

haemolytic anemia
Effect or parameter linked to the endpoint:

haematology (CHD023BE)
Internal remarks:

haemolytic anemia